GREMLIN Database
DUF2851 - Protein of unknown function (DUF2851)
PFAM: PF11013 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 375 (374)
Sequences: 5415 (4530)
Seq/√Len: 234.3
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_K88_E3.4271.00
183_N341_T3.3301.00
5_H34_H3.2971.00
181_A277_L3.2431.00
27_E48_K3.0961.00
95_R99_R3.0651.00
301_R335_D3.0611.00
9_K34_H2.9961.00
79_D96_K2.9591.00
208_H249_Y2.9181.00
66_D69_R2.8301.00
261_F271_T2.7631.00
222_Q242_Y2.7321.00
24_E50_G2.6591.00
182_R194_E2.6001.00
351_K359_K2.5871.00
214_Q241_E2.4721.00
45_A58_V2.4701.00
87_W110_V2.3721.00
186_F333_S2.3711.00
89_H92_E2.3551.00
65_S90_D2.3541.00
230_F235_P2.3251.00
296_S299_E2.2881.00
156_R160_R2.2861.00
174_E178_Q2.2861.00
168_N178_Q2.2701.00
26_I104_L2.2631.00
176_L345_L2.2341.00
168_N175_T2.2101.00
46_K53_L2.1821.00
64_S89_H2.1531.00
88_E107_K2.1251.00
167_Q198_K2.1051.00
145_W149_L2.1051.00
239_K243_R2.0921.00
164_L178_Q2.0911.00
68_Y73_Q2.0691.00
220_F275_A2.0541.00
311_Y319_G2.0381.00
301_R331_K2.0051.00
178_Q198_K1.9631.00
220_F318_F1.9411.00
212_L282_H1.8971.00
195_L258_L1.8761.00
205_L281_L1.8581.00
308_A313_D1.8531.00
11_Q31_P1.8091.00
208_H214_Q1.8031.00
199_S222_Q1.7971.00
335_D370_P1.7891.00
165_L175_T1.7881.00
11_Q15_K1.7661.00
356_E360_E1.7601.00
232_D311_Y1.7481.00
310_D313_D1.7401.00
20_T26_I1.7221.00
181_A197_A1.7151.00
188_V264_L1.7101.00
219_L274_L1.7001.00
186_F268_N1.6881.00
350_G362_A1.6691.00
216_E309_S1.6601.00
105_E108_N1.6581.00
37_D188_V1.6571.00
92_E100_E1.6401.00
237_K240_K1.6371.00
76_P79_D1.6261.00
63_K90_D1.6061.00
5_H60_I1.5991.00
38_A77_A1.5911.00
138_D141_T1.5871.00
213_F237_K1.5641.00
232_D235_P1.5441.00
30_D46_K1.5411.00
317_T320_K1.5361.00
254_L258_L1.5301.00
182_R190_A1.5191.00
95_R101_I1.5121.00
48_K53_L1.5101.00
86_V89_H1.5031.00
37_D263_R1.5001.00
161_I179_L1.4881.00
243_R246_K1.4881.00
177_Y277_L1.4761.00
48_K51_G1.4751.00
71_G74_T1.4321.00
350_G359_K1.4311.00
19_K25_P1.4301.00
244_F248_K1.4261.00
196_L274_L1.4051.00
200_L218_L1.4021.00
343_V366_L1.4001.00
68_Y93_V1.3751.00
43_F57_N1.3721.00
164_L175_T1.3651.00
79_D95_R1.3511.00
235_P319_G1.3461.00
343_V365_L1.3331.00
171_D174_E1.3231.00
225_L256_A1.3211.00
119_E123_N1.3171.00
21_T105_E1.3141.00
194_E198_K1.3021.00
21_T89_H1.3021.00
94_F100_E1.2891.00
204_I249_Y1.2871.00
162_L166_E1.2871.00
230_F319_G1.2861.00
275_A308_A1.2801.00
218_L245_L1.2801.00
313_D326_K1.2751.00
33_L44_N1.2651.00
329_L333_S1.2581.00
312_W315_H1.2581.00
205_L219_L1.2571.00
159_E162_L1.2511.00
255_P258_L1.2451.00
313_D324_K1.2431.00
234_Y238_L1.2391.00
209_R285_Q1.2351.00
279_A282_H1.2351.00
20_T24_E1.2331.00
219_L278_A1.2321.00
355_D358_L1.2281.00
235_P239_K1.2231.00
163_E167_Q1.2221.00
222_Q253_P1.2151.00
364_D368_Q1.2091.00
161_I348_A1.2071.00
196_L259_W1.2071.00
246_K253_P1.2001.00
57_N80_N1.1951.00
236_R239_K1.1951.00
183_N336_L1.1921.00
68_Y91_A1.1851.00
215_L282_H1.1841.00
155_E351_K1.1771.00
314_T321_E1.1771.00
183_N337_L1.1701.00
275_A279_A1.1701.00
213_F241_E1.1681.00
127_W131_E1.1661.00
191_D195_L1.1641.00
25_P50_G1.1631.00
211_N214_Q1.1621.00
174_E203_S1.1611.00
171_D206_R1.1551.00
331_K335_D1.1451.00
196_L223_A1.1421.00
177_Y201_P1.1391.00
307_E326_K1.1341.00
137_V141_T1.1291.00
140_F144_S1.1291.00
236_R240_K1.1251.00
165_L170_N1.1201.00
89_H103_T1.1181.00
214_Q245_L1.1171.00
22_D100_E1.1151.00
307_E313_D1.1091.00
161_I175_T1.1001.00
172_W349_Y1.0971.00
364_D367_E1.0961.00
162_L352_Y1.0931.00
254_L257_S1.0891.00
46_K55_A1.0841.00
171_D203_S1.0831.00
196_L254_L1.0821.00
142_L146_L1.0821.00
346_L361_R1.0811.00
199_S254_L1.0801.00
183_N186_F1.0751.00
29_I53_L1.0741.00
77_A260_K1.0681.00
162_L348_A1.0591.00
305_D334_I1.0551.00
112_K116_E1.0551.00
311_Y317_T1.0521.00
227_E235_P1.0421.00
311_Y315_H1.0401.00
294_A299_E1.0381.00
212_L279_A1.0341.00
37_D187_K1.0331.00
164_L179_L1.0311.00
182_R191_D1.0301.00
200_L222_Q1.0241.00
222_Q251_L1.0231.00
195_L199_S1.0201.00
299_E302_K1.0201.00
64_S90_D1.0201.00
76_P96_K1.0191.00
227_E239_K0.9901.00
148_R155_E0.9901.00
196_L219_L0.9891.00
216_E278_A0.9871.00
165_L348_A0.9841.00
304_F334_I0.9761.00
335_D369_L0.9751.00
79_D97_D0.9711.00
111_P114_L0.9691.00
29_I48_K0.9681.00
301_R334_I0.9671.00
313_D327_K0.9661.00
62_L66_D0.9661.00
86_V105_E0.9621.00
162_L351_K0.9621.00
322_S327_K0.9601.00
147_E367_E0.9591.00
195_L254_L0.9561.00
75_D78_Y0.9541.00
300_L338_L0.9501.00
38_A262_L0.9491.00
30_D33_L0.9451.00
192_P259_W0.9441.00
126_S131_E0.9441.00
348_A352_Y0.9411.00
150_L366_L0.9411.00
244_F247_K0.9381.00
295_K299_E0.9381.00
117_N120_E0.9361.00
177_Y200_L0.9361.00
350_G358_L0.9291.00
2_D34_H0.9291.00
58_V85_V0.9221.00
235_P318_F0.9221.00
61_H75_D0.9111.00
163_E166_E0.9091.00
208_H245_L0.9051.00
180_L341_T0.9041.00
343_V362_A0.9041.00
308_A326_K0.9001.00
143_R147_E0.8990.99
202_L206_R0.8920.99
13_F28_I0.8890.99
160_R163_E0.8830.99
271_T318_F0.8820.99
148_R152_E0.8810.99
219_L281_L0.8810.99
272_I327_K0.8780.99
146_L150_L0.8710.99
330_G336_L0.8710.99
212_L309_S0.8710.99
300_L365_L0.8700.99
206_R209_R0.8690.99
290_K303_L0.8690.99
302_K305_D0.8660.99
243_R247_K0.8570.99
24_E102_P0.8530.99
159_E163_E0.8520.99
294_A300_L0.8520.99
284_S290_K0.8500.99
64_S103_T0.8490.99
297_L301_R0.8470.99
175_T345_L0.8470.99
305_D328_L0.8450.99
158_A348_A0.8430.99
361_R365_L0.8400.99
237_K241_E0.8390.99
195_L198_K0.8370.99
288_F292_L0.8370.99
232_D319_G0.8290.99
133_Q136_E0.8280.99
200_L219_L0.8280.99
336_L341_T0.8280.99
362_A366_L0.8230.99
200_L205_L0.8230.99
173_E206_R0.8230.99
28_I31_P0.8220.99
174_E177_Y0.8180.99
254_L259_W0.8160.99
38_A260_K0.8150.99
160_R182_R0.8150.99
212_L278_A0.8140.99
225_L261_F0.8130.99
338_L343_V0.8120.99
234_Y275_A0.8100.99
259_W274_L0.8080.99
173_E286_N0.8080.99
201_P204_I0.8080.99
85_V104_L0.8070.99
356_E359_K0.8070.99
233_E237_K0.8040.99
227_E246_K0.8040.99
227_E230_F0.8020.99
87_W115_L0.7980.99
141_T144_S0.7970.99
332_S335_D0.7950.99
3_F7_I0.7930.99
350_G361_R0.7900.99
275_A312_W0.7900.99
184_F280_L0.7890.99
346_L350_G0.7870.99
261_F269_F0.7860.99
203_S206_R0.7840.99
126_S132_N0.7830.99
200_L274_L0.7820.99
174_E201_P0.7780.99
177_Y181_A0.7780.99
184_F193_F0.7770.99
221_G226_L0.7760.99
184_F277_L0.7760.99
59_E70_H0.7750.99
174_E202_L0.7740.98
164_L168_N0.7720.98
223_A259_W0.7710.98
3_F115_L0.7700.98
206_R284_S0.7670.98
248_K251_L0.7670.98
314_T324_K0.7660.98
172_W348_A0.7660.98
280_L287_L0.7660.98
298_K301_R0.7640.98
178_Q197_A0.7630.98
143_R146_L0.7630.98
227_E253_P0.7600.98
240_K243_R0.7590.98
330_G333_S0.7580.98
81_V101_I0.7560.98
5_H62_L0.7560.98
218_L249_Y0.7550.98
69_R90_D0.7520.98
14_D109_R0.7520.98
151_I155_E0.7470.98
177_Y202_L0.7420.98
228_E235_P0.7400.98
44_N57_N0.7400.98
147_E151_I0.7400.98
87_W107_K0.7390.98
310_D314_T0.7380.98
177_Y197_A0.7360.98
47_I58_V0.7290.98
177_Y281_L0.7230.98
63_K66_D0.7220.98
128_I131_E0.7180.98
93_V103_T0.7170.98
289_S293_E0.7170.98
52_T55_A0.7150.97
167_Q178_Q0.7120.97
245_L249_Y0.7110.97
7_I110_V0.7100.97
113_S117_N0.7090.97
347_F359_K0.7080.97
209_R286_N0.7080.97
176_L180_L0.7060.97
215_L278_A0.7050.97
202_L281_L0.7050.97
238_L242_Y0.7040.97
304_F342_V0.7040.97
262_L269_F0.7040.97
3_F118_Y0.7020.97
173_E288_F0.7010.97
246_K252_K0.7000.97
62_L87_W0.6980.97
334_I338_L0.6940.97
67_W81_V0.6930.97
59_E72_H0.6920.97
347_F363_L0.6920.97
236_R319_G0.6910.97
14_D17_N0.6880.97
172_W288_F0.6880.97
86_V90_D0.6880.97
230_F239_K0.6880.97
165_L168_N0.6870.97
3_F114_L0.6870.97
86_V103_T0.6860.97
337_L341_T0.6840.97
63_K69_R0.6840.97
279_A283_K0.6830.97
57_N81_V0.6830.97
93_V101_I0.6820.97
329_L334_I0.6800.97
349_Y353_K0.6790.97
204_I218_L0.6780.97
95_R98_G0.6750.96
272_I276_Q0.6750.96
89_H105_E0.6750.96
204_I208_H0.6730.96
332_S373_K0.6730.96
26_I49_I0.6720.96
298_K368_Q0.6710.96
288_F345_L0.6710.96
294_A303_L0.6700.96
306_V329_L0.6690.96
155_E159_E0.6690.96
37_D262_L0.6680.96
177_Y196_L0.6680.96
179_L345_L0.6670.96
275_A311_Y0.6670.96
64_S93_V0.6670.96
35_N43_F0.6640.96
93_V98_G0.6630.96
264_L269_F0.6630.96
115_L119_E0.6620.96
216_E279_A0.6600.96
268_N276_Q0.6600.96
269_F316_Y0.6560.96
184_F333_S0.6550.96
113_S116_E0.6550.96
175_T179_L0.6540.96
31_P60_I0.6510.96
132_N135_A0.6500.96
370_P373_K0.6490.96
116_E119_E0.6460.95
335_D338_L0.6460.95
184_F276_Q0.6460.95
209_R284_S0.6450.95
12_L15_K0.6440.95
240_K244_F0.6410.95
176_L291_I0.6400.95
61_H78_Y0.6360.95
158_A162_L0.6360.95
228_E239_K0.6340.95
178_Q194_E0.6330.95
338_L369_L0.6330.95
301_R305_D0.6330.95
88_E105_E0.6320.95
139_E143_R0.6320.95
290_K294_A0.6320.95
20_T102_P0.6310.95
191_D258_L0.6300.95
230_F236_R0.6300.95
17_N25_P0.6280.95
297_L369_L0.6250.95
228_E256_A0.6240.95
225_L259_W0.6230.94
37_D260_K0.6230.94
18_L104_L0.6200.94
244_F249_Y0.6200.94
220_F271_T0.6200.94
181_A281_L0.6190.94
40_P75_D0.6190.94
79_D98_G0.6190.94
179_L183_N0.6180.94
360_E364_D0.6170.94
295_K361_R0.6160.94
187_K268_N0.6150.94
192_P258_L0.6130.94
1_E4_L0.6120.94
346_L358_L0.6120.94
242_Y246_K0.6120.94
44_N55_A0.6080.94
22_D102_P0.6060.94
283_K307_E0.6060.94
205_L215_L0.6060.94
358_L362_A0.6060.94
29_I46_K0.6060.94
11_Q30_D0.6040.94
229_D239_K0.6040.94
208_H212_L0.6030.93
241_E244_F0.6020.93
146_L149_L0.6020.93
212_L275_A0.6000.93
221_G242_Y0.6000.93
268_N333_S0.5990.93
186_F336_L0.5980.93
276_Q329_L0.5960.93
103_T271_T0.5940.93
11_Q28_I0.5930.93
231_E235_P0.5920.93
312_W318_F0.5910.93
192_P254_L0.5900.93
218_L251_L0.5900.93
219_L277_L0.5890.93
216_E234_Y0.5890.93
267_A325_K0.5890.93
78_Y81_V0.5880.93
275_A309_S0.5880.93
73_Q93_V0.5860.93
161_I344_P0.5860.93
279_A309_S0.5840.92
160_R164_L0.5840.92
14_D18_L0.5840.92
6_Y10_H0.5830.92
166_E170_N0.5810.92
245_L251_L0.5800.92
47_I82_I0.5790.92
164_L167_Q0.5770.92
7_I12_L0.5760.92
244_F251_L0.5750.92
110_V114_L0.5720.92
20_T104_L0.5720.92
110_V115_L0.5710.92
24_E49_I0.5700.91
245_L248_K0.5700.91
133_Q137_V0.5690.91
307_E328_L0.5690.91
187_K190_A0.5670.91
176_L281_L0.5660.91
38_A75_D0.5660.91
61_H66_D0.5650.91
272_I275_A0.5650.91
275_A318_F0.5650.91
291_I304_F0.5640.91
49_I54_W0.5640.91
363_L367_E0.5640.91
135_A142_L0.5620.91
181_A196_L0.5600.91
294_A361_R0.5580.91
134_L142_L0.5550.90
314_T322_S0.5540.90
139_E142_L0.5530.90
333_S336_L0.5520.90
164_L194_E0.5520.90
67_W70_H0.5490.90
117_N121_L0.5490.90
242_Y251_L0.5480.90
89_H100_E0.5480.90
231_E319_G0.5480.90
192_P196_L0.5470.90
199_S242_Y0.5470.90
4_L60_I0.5450.90
214_Q249_Y0.5440.89
158_A347_F0.5410.89
192_P195_L0.5400.89
179_L341_T0.5400.89
334_I342_V0.5390.89
208_H211_N0.5390.89
103_T193_F0.5370.89
174_E197_A0.5360.89
241_E245_L0.5360.89
120_E124_S0.5360.89
188_V263_R0.5330.89
224_G227_E0.5320.88
37_D43_F0.5310.88
172_W345_L0.5300.88
157_K183_N0.5300.88
347_F350_G0.5300.88
181_A274_L0.5290.88
264_L268_N0.5270.88
217_A238_L0.5260.88
10_H14_D0.5250.88
263_R269_F0.5240.88
234_Y312_W0.5240.88
206_R286_N0.5230.88
213_F240_K0.5220.87
216_E275_A0.5210.87
202_L205_L0.5210.87
297_L338_L0.5200.87
25_P51_G0.5200.87
297_L343_V0.5190.87
13_F17_N0.5190.87
288_F349_Y0.5190.87
154_L161_I0.5170.87
118_Y121_L0.5170.87
10_H13_F0.5160.87
234_Y249_Y0.5160.87
9_K42_F0.5160.87
151_I363_L0.5150.87
220_F223_A0.5140.87
154_L347_F0.5130.87
279_A308_A0.5130.87
316_Y327_K0.5110.86
192_P260_K0.5100.86
13_F31_P0.5100.86
4_L7_I0.5060.86
233_E236_R0.5050.86
152_E156_R0.5030.86
144_S147_E0.5030.86
182_R186_F0.5010.85
215_L219_L0.5000.85
5_H9_K0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dorA 2 0.168 50.9 0.966 Contact Map
4zlfA 2 0.136 8.2 0.977 Contact Map
4hhuA 1 0.1733 7.4 0.977 Contact Map
3drfA 1 0.1173 6.3 0.978 Contact Map
1v7wA 2 0.1467 5.9 0.978 Contact Map
3tnyA 1 0.1413 5.7 0.978 Contact Map
2rk3A 2 0.1547 5.6 0.979 Contact Map
3tefA 1 0.1307 5.6 0.979 Contact Map
3uqzA 2 0.168 4.3 0.98 Contact Map
2ej9A 1 0.1627 4.3 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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