GREMLIN Database
DUF2849 - Protein of unknown function (DUF2849)
PFAM: PF11011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (83)
Sequences: 5804 (3560)
Seq/√Len: 390.7
META: 0.916

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_R10_D3.8901.00
17_T23_S3.0261.00
2_V29_A2.6471.00
25_D28_D2.5271.00
32_A39_L2.4771.00
62_L67_P2.1501.00
31_V60_V2.0401.00
7_R24_E1.9821.00
4_T56_Y1.8971.00
23_S28_D1.7751.00
17_T21_G1.7611.00
76_I82_T1.7191.00
12_D24_E1.6841.00
46_A51_R1.6301.00
44_A47_A1.5971.00
2_V60_V1.5511.00
61_E70_V1.5271.00
36_A57_L1.5251.00
72_L76_I1.4341.00
34_D37_E1.3751.00
32_A41_A1.3741.00
63_G68_R1.3731.00
37_E40_L1.3671.00
46_A49_A1.3631.00
40_L44_A1.3531.00
56_Y74_E1.3491.00
2_V58_I1.2081.00
36_A40_L1.2061.00
48_A51_R1.1941.00
27_A67_P1.1761.00
26_L67_P1.1711.00
7_R14_V1.1691.00
63_G66_G1.1401.00
3_V57_L1.1391.00
60_V67_P1.1151.00
14_V52_V1.1041.00
72_L82_T1.0851.00
33_E37_E1.0841.00
4_T15_Y1.0801.00
42_L46_A1.0721.00
59_D71_H1.0541.00
75_R79_A1.0061.00
4_T77_R0.9881.00
15_Y26_L0.9711.00
61_E68_R0.9681.00
47_A55_P0.9611.00
17_T30_A0.9591.00
20_G44_A0.9511.00
75_R78_A0.9411.00
45_A49_A0.9361.00
15_Y78_A0.9361.00
68_R75_R0.9301.00
76_I83_V0.9201.00
3_V16_L0.8951.00
59_D70_V0.8931.00
41_A44_A0.8741.00
71_H76_I0.8721.00
42_L45_A0.8401.00
8_L53_V0.8271.00
47_A54_G0.8261.00
39_L43_A0.8251.00
40_L43_A0.8231.00
3_V40_L0.8141.00
71_H75_R0.8141.00
3_V43_A0.8091.00
39_L42_L0.7941.00
30_A42_L0.7901.00
7_R51_R0.7841.00
52_V55_P0.7841.00
69_P78_A0.7801.00
35_E39_L0.7771.00
37_E41_A0.7481.00
4_T58_I0.7441.00
79_A84_R0.7441.00
17_T28_D0.7311.00
9_R12_D0.7251.00
32_A35_E0.7201.00
30_A38_A0.7021.00
3_V32_A0.6920.99
39_L46_A0.6890.99
27_A66_G0.6890.99
44_A48_A0.6810.99
44_A54_G0.6730.99
62_L65_G0.6620.99
61_E75_R0.6600.99
49_A52_V0.6550.99
46_A54_G0.6530.99
35_E38_A0.6520.99
30_A41_A0.6420.99
6_N13_V0.6330.99
7_R12_D0.6330.99
16_L48_A0.6170.99
43_A47_A0.6130.99
26_L78_A0.6130.99
12_D84_R0.6130.99
34_D42_L0.6080.99
71_H78_A0.6030.99
74_E77_R0.6030.99
54_G73_R0.5910.98
18_A30_A0.5910.98
31_V62_L0.5910.98
10_D24_E0.5810.98
43_A55_P0.5780.98
16_L32_A0.5750.98
41_A48_A0.5740.98
2_V26_L0.5690.98
38_A57_L0.5670.98
16_L30_A0.5660.98
21_G24_E0.5590.98
15_Y71_H0.5560.98
36_A39_L0.5510.98
53_V60_V0.5500.97
37_E43_A0.5500.97
5_A52_V0.5490.97
15_Y57_L0.5480.97
26_L60_V0.5450.97
15_Y58_I0.5440.97
69_P75_R0.5330.97
68_R79_A0.5220.97
47_A50_N0.5200.96
3_V52_V0.5070.96
58_I71_H0.5040.96
29_A80_G0.5040.96
13_V53_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dj2A 2 0.7907 10.1 0.904 Contact Map
4m9dA 2 0.8488 8.8 0.907 Contact Map
3r7tA 4 0.7674 8.1 0.908 Contact Map
3hidA 2 0.8256 7.8 0.909 Contact Map
2gk3A 5 0.5349 6.9 0.911 Contact Map
1g8mA 2 0.9302 6.7 0.912 Contact Map
3sozA 3 0.5233 6.5 0.912 Contact Map
3ue9A 2 0.8488 6.3 0.913 Contact Map
3zzmA 2 0.9186 5.8 0.914 Contact Map
2v0xA 2 0.1744 5.1 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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