GREMLIN Database
DUF2846 - Protein of unknown function (DUF2846)
PFAM: PF11008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (104)
Sequences: 4073 (3162)
Seq/√Len: 310.1
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_D73_H3.9391.00
29_A99_A3.4301.00
100_E103_K3.1431.00
30_R65_Y2.8471.00
30_R67_D2.8211.00
28_K69_P2.7261.00
31_V68_V2.5371.00
72_E98_T2.5001.00
74_T94_S2.4891.00
56_G64_F2.4811.00
72_E96_T2.1941.00
30_R104_T2.1791.00
74_T96_T2.0261.00
58_L109_Q1.9291.00
27_G101_A1.7961.00
49_Y54_V1.7621.00
50_L68_V1.7201.00
55_V66_V1.6931.00
11_S14_Q1.6551.00
68_V73_H1.6191.00
75_I107_V1.5121.00
39_F42_A1.5061.00
14_Q17_A1.4921.00
15_D19_K1.4861.00
47_D54_V1.4411.00
97_L105_Y1.4121.00
15_D18_A1.3901.00
29_A105_Y1.3791.00
25_P67_D1.3541.00
34_Y108_R1.3511.00
36_P108_R1.3461.00
47_D57_E1.2991.00
39_F61_G1.2081.00
76_S94_S1.1771.00
95_L107_V1.1741.00
31_V75_I1.1721.00
25_P28_K1.1631.00
70_P101_A1.1401.00
28_K67_D1.1291.00
50_L75_I1.1281.00
99_A105_Y1.0951.00
68_V99_A1.0641.00
50_L73_H1.0571.00
49_Y76_S1.0421.00
42_A60_P1.0351.00
33_V66_V1.0251.00
33_V75_I1.0011.00
69_P73_H0.9991.00
7_V10_A0.9991.00
41_G44_L0.9901.00
48_V58_L0.9861.00
35_R41_G0.9811.00
50_L55_V0.9721.00
52_G76_S0.9611.00
77_T109_Q0.9061.00
15_D21_F0.9001.00
79_S91_G0.8971.00
17_A21_F0.8941.00
45_K57_E0.8941.00
32_Y63_Y0.8841.00
16_A20_P0.8621.00
24_P27_G0.8571.00
49_Y78_E0.8491.00
21_F106_Y0.8491.00
100_E105_Y0.8491.00
12_P16_A0.8481.00
27_G102_G0.8301.00
24_P30_R0.7991.00
18_A32_Y0.7971.00
34_Y107_V0.7971.00
58_L77_T0.7941.00
14_Q18_A0.7811.00
45_K59_A0.7780.99
31_V99_A0.7780.99
73_H99_A0.7780.99
58_L64_F0.7600.99
50_L66_V0.7550.99
17_A20_P0.7540.99
36_P110_E0.7530.99
10_A13_E0.7490.99
10_A14_Q0.7460.99
52_G74_T0.7410.99
81_E84_P0.7410.99
18_A21_F0.7370.99
39_F60_P0.7300.99
32_Y104_T0.7290.99
40_F43_A0.7180.99
39_F43_A0.7140.99
17_A22_P0.7100.99
36_P39_F0.7020.99
97_L107_V0.7020.99
12_P17_A0.6970.99
19_K22_P0.6950.99
24_P28_K0.6930.99
16_A19_K0.6930.99
78_E92_T0.6910.99
33_V55_V0.6890.99
11_S16_A0.6860.99
46_P77_T0.6800.99
9_M12_P0.6780.99
10_A18_A0.6770.99
32_Y65_Y0.6760.99
13_E19_K0.6730.99
14_Q20_P0.6600.98
49_Y52_G0.6580.98
8_P12_P0.6540.98
53_K68_V0.6510.98
53_K66_V0.6460.98
12_P15_D0.6390.98
48_V64_F0.6350.98
37_S60_P0.6340.98
21_F104_T0.6270.98
24_P67_D0.6270.98
44_L109_Q0.6210.98
16_A21_F0.6100.97
9_M14_Q0.6090.97
8_P11_S0.6050.97
79_S83_E0.6030.97
38_S60_P0.6020.97
59_A62_T0.5990.97
31_V97_L0.5920.97
5_A8_P0.5890.97
33_V64_F0.5860.97
31_V66_V0.5800.96
76_S92_T0.5770.96
11_S18_A0.5760.96
21_F30_R0.5710.96
7_V59_A0.5700.96
13_E16_A0.5690.96
67_D104_T0.5680.96
48_V109_Q0.5680.96
45_K58_L0.5660.96
46_P58_L0.5650.96
63_Y105_Y0.5650.96
38_S41_G0.5620.96
34_Y62_T0.5580.95
38_S93_N0.5580.95
37_S42_A0.5570.95
29_A101_A0.5550.95
33_V56_G0.5540.95
37_S108_R0.5540.95
68_V105_Y0.5510.95
48_V77_T0.5460.95
79_S111_I0.5440.95
33_V50_L0.5430.95
13_E17_A0.5400.95
21_F32_Y0.5350.94
44_L79_S0.5170.93
3_G9_M0.5160.93
22_P65_Y0.5140.93
15_D62_T0.5100.93
9_M59_A0.5050.92
2_A5_A0.5040.92
98_T105_Y0.5040.92
18_A63_Y0.5030.92
54_V57_E0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h8lA 1 0.8306 32.4 0.884 Contact Map
2uvfA 2 0.8145 29.8 0.886 Contact Map
2vzsA 1 0 28.9 0.887 Contact Map
3pe9A 1 0.7097 28.1 0.887 Contact Map
1uwyA 1 0.8387 26.1 0.889 Contact Map
1xpnA 1 0.871 25 0.89 Contact Map
3wnoA 2 0.9597 21.5 0.893 Contact Map
2vzpA 1 0.7339 19.8 0.895 Contact Map
3pddA 1 0.879 17.7 0.898 Contact Map
2wgnB 1 0.7823 15.2 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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