GREMLIN Database
DUF2844 - Protein of unknown function (DUF2844)
PFAM: PF11005 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 133 (130)
Sequences: 2583 (2023)
Seq/√Len: 177.4
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_L123_L4.6001.00
106_E117_R4.3161.00
13_Q16_Q3.7131.00
4_A7_G3.0501.00
21_A36_I3.0041.00
35_E45_R2.7711.00
102_D122_S2.6491.00
101_P121_P2.5161.00
77_Q100_T2.4151.00
124_L130_A2.1771.00
12_V15_D2.1501.00
31_Y55_F2.1351.00
97_R106_E2.0431.00
7_G73_S1.8721.00
68_R76_D1.7871.00
64_M107_S1.7781.00
74_Y77_Q1.7531.00
11_S15_D1.7501.00
110_H114_F1.7261.00
25_V34_H1.7231.00
77_Q102_D1.7101.00
78_Y105_V1.6741.00
92_G95_P1.6261.00
43_V60_Q1.6201.00
64_M114_F1.6091.00
104_V119_Y1.5431.00
33_V45_R1.5421.00
15_D19_L1.5241.00
45_R58_A1.4801.00
99_Q106_E1.4561.00
16_Q23_L1.4281.00
56_A130_A1.4271.00
42_T61_G1.4211.00
91_G94_R1.4191.00
76_D79_Q1.4151.00
38_L42_T1.3891.00
48_V54_V1.3871.00
68_R75_F1.3491.00
15_D36_I1.3381.00
129_S132_D1.3371.00
82_A96_L1.3161.00
49_S123_L1.3121.00
74_Y120_L1.2821.00
34_H48_V1.2601.00
66_D69_Q1.2551.00
59_W116_G1.2361.00
108_G115_S1.2191.00
107_S114_F1.1911.00
9_A32_T1.1731.00
9_A13_Q1.1471.00
45_R60_Q1.1341.00
56_A128_V1.1321.00
24_R35_E1.1261.00
12_V19_L1.0931.00
110_H113_A1.0911.00
4_A72_G1.0811.00
109_G113_A1.0561.00
32_T50_P1.0340.99
35_E43_V1.0240.99
23_L26_T1.0190.99
30_G50_P1.0130.99
108_G111_M1.0000.99
124_L129_S0.9980.99
25_V32_T0.9930.99
78_Y82_A0.9500.99
76_D80_A0.9400.99
36_I46_E0.9210.99
93_R96_L0.9140.99
62_P114_F0.9140.99
17_A20_K0.9070.99
7_G72_G0.9070.99
17_A22_T0.9040.99
18_R66_D0.8990.99
31_Y132_D0.8940.99
9_A12_V0.8910.98
16_Q19_L0.8870.98
61_G112_R0.8860.98
22_T25_V0.8850.98
75_F79_Q0.8730.98
8_D53_K0.8690.98
44_V70_L0.8540.98
30_G132_D0.8520.98
30_G127_G0.8390.98
31_Y119_Y0.8310.98
42_T62_P0.8290.98
102_D121_P0.8240.97
102_D120_L0.7980.97
95_P108_G0.7950.97
22_T26_T0.7900.97
63_F111_M0.7880.97
124_L128_V0.7880.97
99_Q119_Y0.7840.97
99_Q121_P0.7630.96
3_A6_G0.7580.96
124_L127_G0.7570.96
24_R37_T0.7540.96
104_V121_P0.7420.95
98_I103_L0.7420.95
32_T93_R0.7390.95
30_G128_V0.7390.95
83_Q131_D0.7370.95
66_D126_A0.7330.95
77_Q120_L0.7320.95
117_R131_D0.7310.95
76_D90_R0.7280.95
91_G95_P0.7270.95
62_P112_R0.7260.95
82_A93_R0.7250.95
23_L28_A0.7230.95
47_Y113_A0.7150.94
42_T63_F0.7130.94
33_V55_F0.7120.94
90_R94_R0.7110.94
123_L132_D0.7110.94
63_F68_R0.7070.94
34_H69_Q0.7020.94
11_S49_S0.7020.94
13_Q22_T0.6990.94
9_A48_V0.6960.94
4_A54_V0.6910.93
80_A89_R0.6880.93
12_V18_R0.6870.93
102_D107_S0.6840.93
66_D114_F0.6780.93
2_F10_A0.6730.92
51_A54_V0.6700.92
15_D69_Q0.6690.92
36_I70_L0.6620.92
63_F114_F0.6580.91
11_S19_L0.6490.91
109_G114_F0.6480.91
8_D12_V0.6430.91
50_P128_V0.6400.90
57_V71_L0.6340.90
1_A5_L0.6310.90
6_G74_Y0.6300.90
57_V61_G0.6290.90
36_I69_Q0.6230.89
60_Q113_A0.6200.89
27_S32_T0.6200.89
98_I105_V0.6150.88
41_G124_L0.6140.88
16_Q79_Q0.6130.88
99_Q130_A0.6080.88
22_T29_A0.6080.88
17_A27_S0.6030.88
46_E60_Q0.6000.87
66_D102_D0.5980.87
71_L75_F0.5970.87
53_K123_L0.5880.86
67_L71_L0.5850.86
71_L92_G0.5820.86
20_K25_V0.5820.86
12_V36_I0.5800.85
37_T40_S0.5790.85
60_Q115_S0.5790.85
10_A18_R0.5770.85
29_A73_S0.5750.85
110_H119_Y0.5750.85
108_G114_F0.5670.84
13_Q23_L0.5660.84
119_Y122_S0.5620.84
73_S84_A0.5600.83
7_G101_P0.5590.83
77_Q82_A0.5580.83
58_A117_R0.5570.83
15_D20_K0.5550.83
9_A19_L0.5540.83
87_A94_R0.5530.83
47_Y58_A0.5520.83
29_A54_V0.5500.82
70_L75_F0.5480.82
67_L105_V0.5460.82
1_A105_V0.5450.82
21_A25_V0.5410.81
81_A100_T0.5390.81
111_M114_F0.5390.81
25_V29_A0.5370.81
40_S63_F0.5370.81
60_Q91_G0.5360.81
33_V39_P0.5340.80
20_K23_L0.5320.80
37_T43_V0.5310.80
79_Q92_G0.5310.80
44_V116_G0.5310.80
13_Q19_L0.5290.80
57_V70_L0.5290.80
126_A130_A0.5240.79
44_V61_G0.5220.79
14_A19_L0.5200.79
46_E95_P0.5130.78
13_Q18_R0.5110.78
39_P81_A0.5080.77
103_L120_L0.5000.76
53_K126_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vjkA 1 0.2556 6.4 0.944 Contact Map
4wijA 2 0.6992 4.5 0.948 Contact Map
2gkpA 1 0.3759 4.4 0.948 Contact Map
4irfA 1 0.4211 4.3 0.949 Contact Map
2q5wD 1 0.2331 4.2 0.949 Contact Map
3ttyA 4 0.9699 4 0.949 Contact Map
4hroA 1 0.2556 3.3 0.952 Contact Map
2g1eA 1 0.2256 2.9 0.953 Contact Map
1i7fA 2 0.7444 2.4 0.955 Contact Map
3c75L 1 0.0226 2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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