GREMLIN Database
DUF2842 - Protein of unknown function (DUF2842)
PFAM: PF11003 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (60)
Sequences: 6156 (3554)
Seq/√Len: 458.8
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_Y43_A3.0311.00
5_G58_M2.0931.00
20_A43_A2.0301.00
4_I7_V1.9411.00
33_W37_L1.9071.00
18_L21_M1.8671.00
3_L6_T1.6881.00
22_A25_Q1.6831.00
52_K56_R1.6801.00
21_M25_Q1.6461.00
18_L22_A1.6181.00
9_L51_A1.6121.00
7_V11_V1.6121.00
22_A26_A1.5241.00
24_A39_Y1.4611.00
12_L51_A1.4311.00
53_P56_R1.3561.00
32_P35_V1.3001.00
30_R36_Q1.2951.00
16_Y46_A1.2951.00
2_K59_E1.2821.00
52_K55_I1.2761.00
27_L30_R1.2671.00
17_A21_M1.2571.00
23_L26_A1.2561.00
12_L16_Y1.1961.00
3_L7_V1.1801.00
8_A54_L1.1791.00
37_L41_V1.0811.00
8_A12_L1.0531.00
23_L27_L1.0481.00
33_W36_Q1.0431.00
42_V46_A1.0371.00
55_I59_E1.0361.00
31_A36_Q1.0191.00
49_L52_K1.0121.00
19_L22_A1.0121.00
45_L48_V0.9661.00
34_L38_L0.9471.00
51_A55_I0.9441.00
31_A35_V0.9361.00
38_L42_V0.9361.00
24_A40_Y0.9331.00
56_R60_R0.9211.00
15_V18_L0.8831.00
30_R33_W0.8811.00
26_A31_A0.8661.00
38_L41_V0.8581.00
10_L14_P0.8121.00
48_V52_K0.8031.00
49_L53_P0.7721.00
48_V53_P0.7511.00
20_A39_Y0.7491.00
26_A29_G0.7441.00
31_A39_Y0.7411.00
16_Y19_L0.7381.00
27_L31_A0.7321.00
8_A51_A0.7121.00
14_P17_A0.7011.00
4_I8_A0.6941.00
28_L36_Q0.6871.00
36_Q40_Y0.6731.00
45_L49_L0.6651.00
13_L48_V0.6631.00
16_Y20_A0.6591.00
35_V38_L0.6571.00
2_K5_G0.6531.00
44_G48_V0.6531.00
48_V55_I0.6521.00
51_A54_L0.6380.99
28_L45_L0.6360.99
13_L17_A0.6350.99
14_P18_L0.6330.99
21_M24_A0.6030.99
25_Q40_Y0.5940.99
2_K58_M0.5920.99
19_L23_L0.5710.99
20_A24_A0.5490.99
2_K6_T0.5480.98
51_A59_E0.5440.98
21_M29_G0.5380.98
45_L52_K0.5330.98
54_L58_M0.5300.98
6_T10_L0.5250.98
56_R59_E0.5230.98
46_A49_L0.5200.98
57_W60_R0.5040.97
11_V14_P0.5030.97
52_K59_E0.5000.97
9_L12_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l6wA 2 0.5902 2.6 0.885 Contact Map
2kogA 1 0.3443 2.1 0.89 Contact Map
1orqC 4 0.5246 1.7 0.895 Contact Map
2w0cT 1 0.3443 1.7 0.895 Contact Map
1jb0B 1 0.8689 1.5 0.899 Contact Map
4cadC 1 0.918 1.3 0.903 Contact Map
4px7A 1 0.9016 1.2 0.904 Contact Map
3ldcA 3 0.459 1.2 0.905 Contact Map
3hd7A 1 0.3934 1.1 0.908 Contact Map
4wl1A 3 0 1 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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