GREMLIN Database
DUF2840 - Protein of unknown function (DUF2840)
PFAM: PF11000 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (147)
Sequences: 1364 (664)
Seq/√Len: 54.7
META: 0.795

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_D32_R5.6261.00
3_H36_S4.2601.00
63_L82_G3.7761.00
22_P35_A3.6911.00
63_L75_V3.3461.00
141_R145_L3.1971.00
18_R105_E3.0251.00
109_I114_V2.7011.00
64_R83_E2.6771.00
95_E99_Q2.5691.00
43_F65_A2.4061.00
100_A118_Y2.3401.00
66_V72_Y2.2851.00
60_I97_V2.2381.00
104_I114_V2.1761.00
44_A60_I2.0971.00
58_S91_W1.9771.00
51_N55_T1.9701.00
28_L34_V1.9681.00
48_W55_T1.9651.00
8_W14_E1.8720.99
21_R113_D1.8590.99
88_A97_V1.8520.99
64_R70_E1.7360.99
136_T139_R1.5850.98
21_R110_D1.5380.98
26_Q34_V1.4900.97
7_T77_G1.4840.97
49_A57_L1.3930.96
17_I22_P1.3820.96
17_I35_A1.3810.96
115_A118_Y1.3590.95
84_I87_R1.3430.95
4_V43_F1.3300.95
23_A38_A1.3110.94
115_A139_R1.3020.94
61_D75_V1.2990.94
127_A141_R1.2990.94
96_R99_Q1.2950.94
75_V79_R1.2670.93
18_R46_V1.2360.92
104_I107_L1.2350.92
63_L83_E1.2300.92
107_L112_A1.2260.92
137_R141_R1.2160.92
96_R131_P1.2140.92
7_T15_H1.1890.91
4_V37_F1.1250.88
40_G67_A1.1080.88
100_A122_V1.1060.87
75_V84_I1.0960.87
60_I94_V1.0860.86
18_R94_V1.0850.86
118_Y122_V1.0800.86
104_I139_R1.0640.85
45_F77_G1.0520.85
122_V132_P1.0440.84
67_A70_E1.0380.84
11_K17_I1.0370.84
14_E58_S1.0350.84
22_P26_Q1.0270.83
26_Q32_R1.0220.83
24_R36_S1.0210.83
26_Q36_S1.0180.83
4_V65_A1.0140.82
22_P118_Y1.0120.82
138_E141_R1.0000.82
25_E33_R0.9990.81
73_Q84_I0.9950.81
76_P129_G0.9940.81
24_R38_A0.9930.81
135_Y140_H0.9800.80
73_Q77_G0.9680.79
66_V83_E0.9630.79
50_A57_L0.9600.79
125_R128_A0.9590.79
5_E11_K0.9570.79
28_L32_R0.9560.78
30_R55_T0.9550.78
104_I111_P0.9550.78
3_H9_I0.9410.77
2_T65_A0.9360.77
73_Q89_S0.9280.76
73_Q104_I0.9200.76
88_A127_A0.9190.76
29_D94_V0.8910.73
42_V95_E0.8880.73
16_W120_R0.8870.73
86_L97_V0.8870.73
23_A36_S0.8820.73
5_E34_V0.8780.72
39_P98_L0.8690.72
137_R144_L0.8570.70
48_W53_Y0.8540.70
78_V128_A0.8460.69
50_A53_Y0.8440.69
139_R143_W0.8200.67
15_H45_F0.8190.67
83_E120_R0.8130.66
136_T141_R0.8080.66
16_W25_E0.8030.65
107_L137_R0.7940.65
114_V118_Y0.7930.64
37_F41_S0.7910.64
27_I31_R0.7830.63
44_A91_W0.7830.63
93_K102_D0.7810.63
48_W90_G0.7770.63
115_A143_W0.7760.63
39_P116_P0.7740.63
66_V77_G0.7720.62
45_F58_S0.7700.62
21_R108_G0.7660.62
127_A145_L0.7650.62
7_T75_V0.7600.61
51_N56_V0.7460.60
7_T10_E0.7440.59
30_R46_V0.7430.59
70_E77_G0.7320.58
25_E87_R0.7300.58
9_I12_R0.7260.58
26_Q72_Y0.7240.57
8_W11_K0.7190.57
21_R112_A0.7190.57
27_I30_R0.7140.56
95_E139_R0.7100.56
1_L23_A0.7080.56
112_A115_A0.6890.54
54_G102_D0.6890.54
60_I78_V0.6860.53
52_D110_D0.6830.53
49_A56_V0.6780.53
45_F60_I0.6710.52
129_G145_L0.6700.52
84_I145_L0.6680.51
42_V65_A0.6640.51
12_R50_A0.6620.51
100_A104_I0.6600.51
138_E147_R0.6600.51
98_L107_L0.6580.50
111_P114_V0.6570.50
35_A96_R0.6570.50
23_A67_A0.6560.50
41_S65_A0.6550.50
144_L147_R0.6440.49
106_A115_A0.6390.48
22_P27_I0.6380.48
57_L87_R0.6370.48
75_V78_V0.6350.48
13_I147_R0.6340.48
34_V111_P0.6300.47
59_R77_G0.6260.47
3_H26_Q0.6260.47
22_P87_R0.6180.46
38_A108_G0.6130.46
98_L113_D0.6130.46
67_A72_Y0.6120.45
51_N54_G0.6100.45
5_E28_L0.6060.45
100_A114_V0.6030.45
131_P138_E0.6000.44
29_D33_R0.6000.44
110_D117_D0.5990.44
45_F53_Y0.5970.44
13_I29_D0.5940.44
86_L114_V0.5940.44
61_D87_R0.5940.44
50_A55_T0.5920.43
88_A93_K0.5850.43
54_G58_S0.5850.43
99_Q136_T0.5830.42
77_G145_L0.5810.42
9_I27_I0.5790.42
46_V105_E0.5760.42
15_H77_G0.5750.42
134_P143_W0.5750.42
42_V64_R0.5740.41
53_Y87_R0.5730.41
14_E91_W0.5710.41
143_W146_R0.5700.41
101_I111_P0.5640.40
13_I32_R0.5630.40
44_A102_D0.5600.40
136_T145_L0.5550.39
40_G70_E0.5530.39
38_A41_S0.5520.39
55_T120_R0.5510.39
3_H79_R0.5500.39
25_E31_R0.5470.39
60_I88_A0.5460.39
121_H133_R0.5440.38
96_R128_A0.5440.38
43_F47_R0.5400.38
22_P127_A0.5390.38
23_A41_S0.5370.38
129_G132_P0.5350.37
41_S96_R0.5350.37
95_E147_R0.5320.37
45_F72_Y0.5280.37
130_E134_P0.5240.36
108_G112_A0.5240.36
99_Q134_P0.5220.36
42_V103_A0.5210.36
15_H96_R0.5200.36
27_I82_G0.5200.36
30_R44_A0.5190.36
56_V92_P0.5180.36
48_W54_G0.5180.36
44_A129_G0.5170.36
22_P100_A0.5130.35
134_P138_E0.5120.35
37_F122_V0.5110.35
111_P117_D0.5110.35
99_Q109_I0.5080.35
34_V141_R0.5070.35
25_E34_V0.5050.34
67_A108_G0.5050.34
30_R129_G0.5010.34
99_Q139_R0.5010.34
75_V131_P0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y8uA 1 0.7905 26.4 0.94 Contact Map
2c1iA 1 0.8041 21.7 0.942 Contact Map
2j13A 1 0.6689 20.9 0.943 Contact Map
2cc0A 2 0.7703 16.8 0.945 Contact Map
4qlxA 2 0.9054 9.2 0.951 Contact Map
1ny1A 1 0.7973 9 0.951 Contact Map
2iw0A 1 0.8851 8.1 0.952 Contact Map
4m1bA 1 0.7365 6.8 0.954 Contact Map
1o65A 1 0.8378 6.4 0.955 Contact Map
1vm6A 4 0.4257 6.1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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