GREMLIN Database
DUF2839 - Protein of unknown function (DUF2839)
PFAM: PF10999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (67)
Sequences: 561 (272)
Seq/√Len: 33.2
META: 0.774

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_T60_I2.6761.00
32_A36_V2.4060.99
53_L57_V2.3890.99
12_G15_Y2.1010.98
45_I48_G2.0670.98
40_T43_A2.0270.98
28_T31_Q1.9820.98
14_R17_K1.8360.96
12_G16_G1.7860.96
18_E30_N1.6980.94
43_A46_G1.6020.92
19_P30_N1.5680.92
36_V39_T1.5610.91
19_P64_F1.4960.90
27_I32_A1.4700.89
48_G52_V1.4350.87
20_R24_W1.4250.87
39_T42_G1.4160.87
46_G57_V1.4030.86
10_G13_P1.3920.86
36_V43_A1.3600.84
21_I31_Q1.3140.82
20_R63_A1.2690.80
26_P31_Q1.2610.80
22_L25_L1.2430.79
27_I31_Q1.2150.77
21_I26_P1.2010.76
36_V40_T1.1950.76
5_K37_K1.1840.75
35_F42_G1.1790.75
55_V60_I1.1390.72
8_K12_G1.1170.71
35_F39_T1.1020.70
62_P65_G1.0390.65
20_R53_L1.0370.65
55_V59_F1.0040.62
45_I52_V1.0020.62
49_L52_V0.9860.61
44_W47_I0.9750.60
10_G14_R0.9630.59
20_R28_T0.9480.58
22_L27_I0.9420.57
46_G50_L0.9230.56
11_L15_Y0.9200.56
1_M4_A0.9130.55
7_R13_P0.9070.54
2_G5_K0.9060.54
36_V51_V0.8960.54
29_K32_A0.8530.50
5_K64_F0.8510.50
53_L59_F0.8310.48
5_K9_Q0.8100.46
41_R45_I0.8090.46
19_P25_L0.8070.46
1_M5_K0.7980.45
61_G67_W0.7960.45
19_P29_K0.7800.44
37_K49_L0.7770.44
4_A55_V0.7600.42
49_L56_T0.7590.42
17_K53_L0.7540.42
35_F38_W0.7530.42
32_A40_T0.7500.41
11_L17_K0.7390.41
57_V64_F0.7250.39
60_I64_F0.7230.39
37_K41_R0.7100.38
49_L53_L0.6980.37
8_K49_L0.6920.37
30_N66_W0.6790.36
3_E64_F0.6780.36
21_I27_I0.6740.35
2_G6_R0.6740.35
38_W42_G0.6680.35
11_L14_R0.6500.34
8_K14_R0.6360.33
1_M6_R0.6090.31
34_Q37_K0.6030.30
54_W58_R0.6000.30
9_Q12_G0.5840.29
23_P27_I0.5810.29
20_R26_P0.5800.29
38_W41_R0.5780.28
35_F43_A0.5720.28
20_R31_Q0.5720.28
5_K8_K0.5690.28
13_P16_G0.5680.28
8_K15_Y0.5640.28
5_K32_A0.5560.27
63_A66_W0.5400.26
32_A43_A0.5390.26
43_A47_I0.5370.26
62_P67_W0.5340.26
39_T45_I0.5330.26
28_T63_A0.5270.25
34_Q55_V0.5190.25
3_E6_R0.5150.24
39_T50_L0.5090.24
43_A50_L0.5030.24
60_I66_W0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mmuA 1 0.4179 58.8 0.878 Contact Map
3prhA 2 0 27.8 0.9 Contact Map
2axcA 1 0.3433 3.9 0.932 Contact Map
2jlnA 1 0.7761 3.5 0.934 Contact Map
1n0uA 1 0.3582 3 0.936 Contact Map
2k4fA 1 0.6269 2.8 0.937 Contact Map
2h88C 2 0.9851 2.8 0.937 Contact Map
1zoyC 1 0.9701 2.8 0.937 Contact Map
4w224 1 0.3582 2.5 0.939 Contact Map
4cr2W 1 0 2.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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