GREMLIN Database
DUF2838 - Protein of unknown function (DUF2838)
PFAM: PF10998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (111)
Sequences: 648 (465)
Seq/√Len: 44.1
META: 0.585

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_T70_W3.8741.00
83_F87_N3.4511.00
16_G20_G3.1871.00
57_F85_L3.1811.00
37_L110_T3.0321.00
9_V103_F2.9341.00
11_N33_Q2.7991.00
41_R59_Y2.4021.00
93_A97_W2.3211.00
67_L72_F2.2721.00
46_R51_H2.2281.00
106_L110_T2.0020.99
53_F97_W1.9740.99
17_Y20_G1.8470.99
105_S108_K1.7350.98
41_R45_Y1.7240.98
67_L71_V1.6710.97
8_G103_F1.6530.97
8_G23_P1.6090.97
94_I99_N1.5870.96
4_S9_V1.5850.96
97_W108_K1.5780.96
17_Y21_A1.5190.95
43_Y47_K1.5170.95
45_Y59_Y1.5100.95
1_D8_G1.4830.95
57_F61_V1.4630.94
66_L70_W1.4260.93
4_S8_G1.4200.93
13_F16_G1.4040.93
25_Y28_Y1.3940.93
89_P94_I1.3940.93
57_F70_W1.3780.92
99_N107_D1.3690.92
61_V85_L1.3480.91
35_L39_P1.3170.90
34_L38_L1.3000.90
98_R108_K1.2890.89
14_I29_W1.2630.88
40_I105_S1.2280.87
73_P78_L1.2020.86
102_V108_K1.1880.85
24_E28_Y1.1320.82
45_Y56_D1.1320.82
76_K80_I1.1210.82
52_Y55_L1.1070.81
107_D111_S1.0890.80
26_F30_Y1.0880.80
6_T51_H1.0300.76
20_G53_F1.0170.75
7_L74_K1.0100.74
15_S29_W0.9990.74
64_L78_L0.9970.73
45_Y51_H0.9970.73
61_V84_A0.9700.71
44_T48_K0.9700.71
3_V103_F0.9630.71
25_Y49_G0.9590.70
30_Y53_F0.9590.70
83_F98_R0.9530.70
12_I19_L0.9440.69
46_R55_L0.9150.67
81_A85_L0.9080.66
61_V90_L0.8520.61
5_F8_G0.8510.61
1_D86_A0.8470.61
46_R52_Y0.8310.59
59_Y97_W0.8280.59
30_Y56_D0.8190.58
3_V7_L0.8190.58
26_F65_L0.8180.58
33_Q109_V0.8140.58
48_K81_A0.8110.57
36_Y39_P0.8110.57
62_N78_L0.8110.57
56_D98_R0.8090.57
1_D57_F0.8020.57
45_Y106_L0.7930.56
7_L26_F0.7900.55
67_L76_K0.7870.55
18_L91_A0.7760.54
57_F88_G0.7750.54
18_L29_W0.7700.53
103_F109_V0.7540.52
69_I75_S0.7470.51
1_D47_K0.7440.51
63_L74_K0.7390.50
54_L59_Y0.7330.50
72_F75_S0.7300.50
90_L94_I0.7300.50
72_F86_A0.7270.49
65_L95_I0.7200.49
65_L82_C0.7200.49
14_I25_Y0.7100.48
43_Y65_L0.7100.48
40_I90_L0.6930.46
54_L80_I0.6920.46
98_R107_D0.6910.46
101_L104_H0.6910.46
96_A101_L0.6820.45
71_V75_S0.6770.45
32_V66_L0.6740.44
67_L73_P0.6730.44
1_D16_G0.6680.44
99_N102_V0.6680.44
43_Y46_R0.6670.44
50_W77_R0.6640.43
6_T10_L0.6590.43
45_Y108_K0.6440.41
82_C89_P0.6410.41
20_G85_L0.6280.40
102_V105_S0.6250.40
1_D21_A0.6220.39
53_F99_N0.6170.39
86_A91_A0.6170.39
46_R82_C0.6150.39
45_Y65_L0.6140.39
4_S65_L0.6110.38
100_S108_K0.6100.38
67_L78_L0.6040.38
17_Y71_V0.6040.38
56_D97_W0.6010.37
51_H59_Y0.6000.37
45_Y107_D0.6000.37
5_F23_P0.6000.37
6_T68_Y0.5990.37
2_K52_Y0.5990.37
26_F54_L0.5910.37
45_Y98_R0.5910.37
24_E35_L0.5900.36
11_N22_Y0.5870.36
20_G68_Y0.5820.36
36_Y82_C0.5820.36
6_T77_R0.5800.36
98_R102_V0.5730.35
1_D39_P0.5690.35
13_F64_L0.5600.34
15_S74_K0.5600.34
5_F104_H0.5600.34
15_S33_Q0.5580.34
10_L46_R0.5540.33
101_L108_K0.5520.33
15_S18_L0.5520.33
39_P84_A0.5500.33
41_R107_D0.5490.33
3_V95_I0.5460.33
16_G34_L0.5430.32
16_G97_W0.5380.32
31_T68_Y0.5380.32
28_Y81_A0.5330.32
28_Y66_L0.5320.31
12_I15_S0.5310.31
5_F46_R0.5310.31
35_L63_L0.5300.31
12_I34_L0.5290.31
72_F80_I0.5280.31
41_R110_T0.5270.31
46_R92_W0.5220.31
31_T66_L0.5210.31
19_L76_K0.5200.30
30_Y69_I0.5170.30
42_F52_Y0.5140.30
20_G36_Y0.5140.30
30_Y94_I0.5030.29
59_Y75_S0.5010.29
39_P87_N0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.4324 5.9 0.934 Contact Map
4ev6A 3 0.4505 5.4 0.935 Contact Map
3fqmA 2 0.1892 2.5 0.945 Contact Map
4p02B 1 0.4054 1.2 0.954 Contact Map
3zd0A 1 0.4144 1.1 0.955 Contact Map
1hksA 1 0.3604 0.8 0.958 Contact Map
2mtsA 1 0.3964 0.8 0.958 Contact Map
2jm6A 1 0.1081 0.8 0.959 Contact Map
2lzlA 2 0.2252 0.7 0.96 Contact Map
4w8pB 1 0.0811 0.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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