DUF2837 - PFAM28P - GREMLIN Contacts

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DUF2837 - Protein of unknown function (DUF2837)

PFAM:	PF10997	Sequences: LTFIIHLIETLAYSVRIAGVRTGRIAVSFSLFNILVLVSRTANMFQAPLLAKLVETAIKSGALAGLLGDFRLIILAATLGTLLGALLIPTFQRLFSRAIEHFEEHGSVPRLLLHGFSPRGLKRIRKSIRLPSLSNLKGLRLRGIPKRLLLLNVLATAIYTVGVLAALYAGYLNPEYRVTASQLSGVINGIATILLFLFIDPQLSVITDDVVRGKRSESDFRRMVVYLVGSRLLGTLLAQLLLVPAAYLIAWVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	253 (252)
Sequences:	961 (636)
Seq/√Len:	40.0
META:	0.745

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
78_T	232_L	4.695	1.00
51_A	55_E	4.377	1.00
81_T	232_L	3.465	1.00
73_I	164_L	3.251	1.00
17_I	21_R	3.195	1.00
199_I	204_S	3.170	1.00
178_V	181_S	3.092	1.00
3_F	83_L	3.070	1.00
32_F	84_G	2.847	1.00
210_V	220_F	2.844	1.00
9_E	12_A	2.691	1.00
82_L	232_L	2.640	1.00
165_A	245_A	2.548	1.00
52_K	56_T	2.449	1.00
168_Y	172_L	2.376	1.00
184_S	188_N	2.311	1.00
78_T	235_T	2.145	0.99
66_L	171_Y	2.136	0.99
74_I	160_T	2.121	0.99
162_G	166_A	2.108	0.99
90_T	128_I	1.980	0.99
179_T	183_L	1.961	0.99
71_R	239_Q	1.937	0.99
108_V	184_S	1.896	0.98
30_S	204_S	1.872	0.98
7_L	11_L	1.858	0.98
75_L	236_L	1.845	0.98
75_L	82_L	1.828	0.98
25_I	211_V	1.827	0.98
226_Y	230_S	1.801	0.98
74_I	242_L	1.762	0.97
78_T	161_V	1.715	0.97
158_I	248_L	1.712	0.97
163_V	188_N	1.707	0.97
15_V	91_F	1.694	0.97
34_I	197_L	1.692	0.97
2_T	6_H	1.679	0.97
206_I	220_F	1.655	0.96
30_S	105_H	1.648	0.96
85_A	187_I	1.618	0.96
129_R	133_L	1.597	0.95
156_T	159_Y	1.593	0.95
231_R	238_A	1.593	0.95
16_R	19_G	1.546	0.94
44_M	185_G	1.544	0.94
6_H	231_R	1.527	0.94
10_T	15_V	1.527	0.94
106_G	209_D	1.503	0.94
215_R	219_D	1.479	0.93
176_Y	180_A	1.468	0.93
51_A	185_G	1.441	0.92
79_L	134_S	1.438	0.92
79_L	83_L	1.426	0.92
43_N	47_A	1.419	0.91
206_I	210_V	1.413	0.91
71_R	167_L	1.397	0.91
209_D	214_K	1.395	0.91
195_L	206_I	1.384	0.90
148_L	171_Y	1.378	0.90
6_H	77_A	1.374	0.90
71_R	78_T	1.370	0.90
58_I	177_R	1.358	0.90
55_E	177_R	1.346	0.89
32_F	36_V	1.329	0.89
114_H	118_P	1.320	0.88
49_L	101_H	1.315	0.88
170_G	177_R	1.315	0.88
85_A	228_V	1.313	0.88
67_L	242_L	1.311	0.88
22_T	183_L	1.293	0.87
41_T	181_S	1.291	0.87
132_S	136_L	1.289	0.87
143_G	219_D	1.286	0.87
3_F	79_L	1.275	0.86
246_A	250_A	1.273	0.86
150_L	154_L	1.264	0.86
42_A	158_I	1.236	0.85
99_I	182_Q	1.235	0.85
202_Q	206_I	1.224	0.84
167_L	231_R	1.208	0.83
27_V	30_S	1.208	0.83
162_G	188_N	1.208	0.83
190_I	194_L	1.207	0.83
177_R	183_L	1.202	0.83
155_A	159_Y	1.199	0.83
36_V	78_T	1.180	0.82
163_V	239_Q	1.178	0.82
233_L	237_L	1.173	0.81
27_V	102_F	1.166	0.81
2_T	5_I	1.159	0.81
37_L	41_T	1.156	0.80
75_L	214_K	1.155	0.80
36_V	40_R	1.134	0.79
78_T	81_T	1.128	0.79
58_I	61_G	1.125	0.78
106_G	233_L	1.122	0.78
217_E	221_R	1.120	0.78
40_R	195_L	1.117	0.78
96_S	149_L	1.116	0.78
191_A	198_F	1.108	0.77
237_L	240_L	1.102	0.77
53_L	69_D	1.100	0.77
95_F	166_A	1.098	0.77
239_Q	244_P	1.093	0.76
8_I	32_F	1.092	0.76
161_V	165_A	1.090	0.76
70_F	242_L	1.087	0.76
243_V	247_Y	1.084	0.76
206_I	215_R	1.082	0.76
155_A	203_L	1.082	0.76
44_M	159_Y	1.076	0.75
94_L	240_L	1.071	0.75
90_T	131_P	1.069	0.75
17_I	166_A	1.058	0.74
44_M	158_I	1.057	0.74
140_R	143_G	1.046	0.73
46_Q	177_R	1.035	0.72
26_A	152_N	1.034	0.72
62_A	65_G	1.031	0.72
85_A	232_L	1.030	0.72
74_I	77_A	1.030	0.72
61_G	136_L	1.029	0.72
51_A	159_Y	1.029	0.72
32_F	39_S	1.028	0.72
3_F	7_L	1.024	0.72
209_D	215_R	1.022	0.71
41_T	81_T	1.022	0.71
40_R	192_T	1.022	0.71
85_A	95_F	1.017	0.71
236_L	240_L	1.000	0.70
76_A	109_P	0.991	0.69
34_I	222_R	0.986	0.69
5_I	21_R	0.984	0.68
164_L	185_G	0.983	0.68
13_Y	152_N	0.979	0.68
247_Y	250_A	0.979	0.68
118_P	125_R	0.976	0.68
55_E	92_Q	0.976	0.68
173_N	250_A	0.976	0.68
166_A	181_S	0.965	0.67
83_L	154_L	0.962	0.67
33_N	192_T	0.958	0.66
83_L	247_Y	0.957	0.66
30_S	159_Y	0.952	0.66
23_G	119_R	0.949	0.66
72_L	76_A	0.948	0.66
180_A	226_Y	0.947	0.65
166_A	249_I	0.945	0.65
158_I	194_L	0.944	0.65
11_L	191_A	0.940	0.65
187_I	248_L	0.933	0.64
24_R	171_Y	0.930	0.64
156_T	228_V	0.927	0.64
36_V	232_L	0.927	0.64
83_L	150_L	0.927	0.64
184_S	192_T	0.927	0.64
27_V	118_P	0.923	0.63
177_R	181_S	0.914	0.63
159_Y	185_G	0.910	0.62
78_T	239_Q	0.909	0.62
112_L	141_L	0.909	0.62
86_L	97_R	0.902	0.62
31_L	97_R	0.902	0.62
9_E	40_R	0.899	0.61
56_T	175_E	0.898	0.61
119_R	123_R	0.894	0.61
236_L	248_L	0.892	0.61
149_L	161_V	0.891	0.61
83_L	112_L	0.889	0.61
89_P	152_N	0.886	0.60
20_V	26_A	0.884	0.60
99_I	195_L	0.883	0.60
108_V	119_R	0.882	0.60
232_L	238_A	0.876	0.59
100_E	136_L	0.874	0.59
61_G	83_L	0.874	0.59
63_L	82_L	0.869	0.59
104_E	114_H	0.868	0.59
42_A	109_P	0.866	0.58
28_S	160_T	0.850	0.57
74_I	141_L	0.850	0.57
10_T	228_V	0.849	0.57
185_G	195_L	0.841	0.56
39_S	48_P	0.839	0.56
162_G	184_S	0.838	0.56
148_L	206_I	0.835	0.56
100_E	242_L	0.829	0.55
4_I	193_I	0.826	0.55
116_F	120_G	0.824	0.55
103_E	145_P	0.820	0.54
23_G	212_R	0.820	0.54
170_G	183_L	0.818	0.54
154_L	241_L	0.816	0.54
97_R	104_E	0.815	0.54
221_R	230_S	0.814	0.54
149_L	230_S	0.811	0.54
78_T	168_Y	0.808	0.53
115_G	236_L	0.808	0.53
54_V	78_T	0.808	0.53
66_L	182_Q	0.805	0.53
35_L	196_F	0.802	0.53
47_A	179_T	0.802	0.53
99_I	104_E	0.801	0.53
1_L	17_I	0.797	0.52
38_V	193_I	0.794	0.52
65_G	116_F	0.792	0.52
44_M	55_E	0.788	0.51
102_F	183_L	0.787	0.51
54_V	66_L	0.784	0.51
47_A	163_V	0.782	0.51
82_L	86_L	0.780	0.51
55_E	185_G	0.780	0.51
173_N	180_A	0.778	0.51
73_I	135_N	0.775	0.50
31_L	78_T	0.774	0.50
204_S	208_D	0.772	0.50
178_V	182_Q	0.770	0.50
66_L	176_Y	0.769	0.50
50_L	177_R	0.765	0.49
218_S	236_L	0.762	0.49
226_Y	229_G	0.759	0.49
80_G	106_G	0.757	0.49
88_I	228_V	0.756	0.48
223_M	227_L	0.753	0.48
117_S	120_G	0.746	0.48
230_S	250_A	0.746	0.48
23_G	142_R	0.743	0.47
213_G	221_R	0.741	0.47
72_L	164_L	0.741	0.47
75_L	247_Y	0.739	0.47
55_E	159_Y	0.739	0.47
144_I	149_L	0.730	0.46
170_G	228_V	0.729	0.46
242_L	249_I	0.728	0.46
97_R	101_H	0.718	0.45
83_L	134_S	0.716	0.45
15_V	36_V	0.712	0.44
12_A	248_L	0.709	0.44
69_D	170_G	0.708	0.44
19_G	25_I	0.706	0.44
233_L	250_A	0.706	0.44
30_S	156_T	0.705	0.44
105_H	108_V	0.697	0.43
86_L	125_R	0.695	0.43
136_L	156_T	0.691	0.43
172_L	246_A	0.690	0.42
14_S	91_F	0.688	0.42
99_I	118_P	0.688	0.42
201_P	208_D	0.684	0.42
215_R	220_F	0.682	0.42
6_H	41_T	0.681	0.42
148_L	202_Q	0.680	0.42
155_A	199_I	0.675	0.41
64_A	83_L	0.674	0.41
198_F	202_Q	0.673	0.41
23_G	57_A	0.673	0.41
222_R	231_R	0.666	0.40
182_Q	185_G	0.665	0.40
10_T	41_T	0.665	0.40
89_P	169_A	0.663	0.40
15_V	78_T	0.662	0.40
124_I	187_I	0.660	0.40
156_T	160_T	0.660	0.40
103_E	223_M	0.660	0.40
189_G	192_T	0.660	0.40
101_H	104_E	0.660	0.40
131_P	184_S	0.655	0.39
37_L	107_S	0.652	0.39
173_N	176_Y	0.650	0.39
18_A	99_I	0.649	0.39
88_I	160_T	0.648	0.39
149_L	153_V	0.646	0.39
30_S	34_I	0.645	0.39
32_F	35_L	0.644	0.38
166_A	171_Y	0.644	0.38
126_K	154_L	0.643	0.38
104_E	137_K	0.643	0.38
34_I	233_L	0.642	0.38
63_L	67_L	0.638	0.38
129_R	138_G	0.636	0.38
161_V	180_A	0.634	0.38
123_R	193_I	0.634	0.38
209_D	216_S	0.628	0.37
36_V	161_V	0.627	0.37
36_V	39_S	0.627	0.37
98_A	248_L	0.627	0.37
45_F	92_Q	0.625	0.37
92_Q	177_R	0.623	0.37
123_R	136_L	0.622	0.37
92_Q	179_T	0.621	0.36
67_L	98_A	0.620	0.36
52_K	111_L	0.618	0.36
6_H	10_T	0.618	0.36
104_E	110_R	0.615	0.36
198_F	204_S	0.610	0.36
56_T	60_S	0.609	0.35
2_T	7_L	0.606	0.35
11_L	91_F	0.605	0.35
76_A	211_V	0.602	0.35
147_R	151_L	0.598	0.35
24_R	213_G	0.597	0.34
58_I	247_Y	0.597	0.34
128_I	216_S	0.596	0.34
87_L	110_R	0.595	0.34
114_H	123_R	0.595	0.34
121_L	130_L	0.593	0.34
170_G	178_V	0.593	0.34
50_L	195_L	0.592	0.34
104_E	118_P	0.591	0.34
155_A	224_V	0.589	0.34
46_Q	194_L	0.588	0.34
234_G	239_Q	0.588	0.34
233_L	247_Y	0.587	0.34
71_R	75_L	0.586	0.34
1_L	20_V	0.584	0.33
167_L	170_G	0.583	0.33
15_V	35_L	0.577	0.33
44_M	51_A	0.577	0.33
51_A	223_M	0.576	0.33
206_I	219_D	0.573	0.32
75_L	232_L	0.573	0.32
135_N	195_L	0.572	0.32
75_L	193_I	0.570	0.32
9_E	53_L	0.569	0.32
74_I	161_V	0.568	0.32
114_H	120_G	0.567	0.32
99_I	135_N	0.561	0.32
167_L	249_I	0.560	0.31
8_I	11_L	0.560	0.31
247_Y	251_W	0.558	0.31
82_L	154_L	0.557	0.31
51_A	155_A	0.555	0.31
113_L	126_K	0.553	0.31
220_F	223_M	0.553	0.31
219_D	223_M	0.549	0.31
83_L	141_L	0.549	0.31
32_F	200_D	0.545	0.30
60_S	116_F	0.542	0.30
58_I	191_A	0.542	0.30
167_L	182_Q	0.542	0.30
222_R	225_V	0.542	0.30
37_L	46_Q	0.541	0.30
133_L	236_L	0.541	0.30
248_L	251_W	0.538	0.30
221_R	231_R	0.538	0.30
240_L	247_Y	0.535	0.29
240_L	251_W	0.534	0.29
186_V	193_I	0.533	0.29
18_A	127_S	0.533	0.29
49_L	95_F	0.526	0.29
27_V	125_R	0.526	0.29
165_A	169_A	0.526	0.29
38_V	84_G	0.526	0.29
141_L	243_V	0.525	0.29
54_V	167_L	0.524	0.29
129_R	132_S	0.524	0.29
48_P	179_T	0.524	0.29
70_F	73_I	0.523	0.29
57_A	99_I	0.522	0.29
13_Y	162_G	0.522	0.29
112_L	165_A	0.522	0.29
71_R	80_G	0.520	0.28
26_A	200_D	0.519	0.28
95_F	212_R	0.515	0.28
74_I	167_L	0.514	0.28
49_L	103_E	0.512	0.28
25_I	70_F	0.510	0.28
148_L	159_Y	0.510	0.28
50_L	77_A	0.509	0.28
92_Q	106_G	0.507	0.27
153_V	230_S	0.507	0.27
9_E	159_Y	0.504	0.27
209_D	220_F	0.503	0.27
9_E	18_A	0.503	0.27
103_E	158_I	0.502	0.27
81_T	231_R	0.502	0.27
203_L	216_S	0.501	0.27
194_L	197_L	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lz6A	1	0.9249	23.7	0.962	Contact Map
3w4tA	1	0.9407	20.7	0.963	Contact Map
4humA	1	0.9565	17.4	0.964	Contact Map
3mktA	1	0.9289	8.1	0.969	Contact Map
1pw4A	1	0.834	6.5	0.971	Contact Map
4jifB	1	0.0751	5.8	0.971	Contact Map
3wdoA	1	0.8379	4.3	0.973	Contact Map
3klyA	3	0.4506	3.4	0.974	Contact Map
3kcuA	3	0.4269	3	0.975	Contact Map
4u4vA	1	0.336	2.7	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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