GREMLIN Database
DUF2837 - Protein of unknown function (DUF2837)
PFAM: PF10997 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 253 (252)
Sequences: 961 (636)
Seq/√Len: 40.0
META: 0.745

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_T232_L4.6951.00
51_A55_E4.3771.00
81_T232_L3.4651.00
73_I164_L3.2511.00
17_I21_R3.1951.00
199_I204_S3.1701.00
178_V181_S3.0921.00
3_F83_L3.0701.00
32_F84_G2.8471.00
210_V220_F2.8441.00
9_E12_A2.6911.00
82_L232_L2.6401.00
165_A245_A2.5481.00
52_K56_T2.4491.00
168_Y172_L2.3761.00
184_S188_N2.3111.00
78_T235_T2.1450.99
66_L171_Y2.1360.99
74_I160_T2.1210.99
162_G166_A2.1080.99
90_T128_I1.9800.99
179_T183_L1.9610.99
71_R239_Q1.9370.99
108_V184_S1.8960.98
30_S204_S1.8720.98
7_L11_L1.8580.98
75_L236_L1.8450.98
75_L82_L1.8280.98
25_I211_V1.8270.98
226_Y230_S1.8010.98
74_I242_L1.7620.97
78_T161_V1.7150.97
158_I248_L1.7120.97
163_V188_N1.7070.97
15_V91_F1.6940.97
34_I197_L1.6920.97
2_T6_H1.6790.97
206_I220_F1.6550.96
30_S105_H1.6480.96
85_A187_I1.6180.96
129_R133_L1.5970.95
156_T159_Y1.5930.95
231_R238_A1.5930.95
16_R19_G1.5460.94
44_M185_G1.5440.94
6_H231_R1.5270.94
10_T15_V1.5270.94
106_G209_D1.5030.94
215_R219_D1.4790.93
176_Y180_A1.4680.93
51_A185_G1.4410.92
79_L134_S1.4380.92
79_L83_L1.4260.92
43_N47_A1.4190.91
206_I210_V1.4130.91
71_R167_L1.3970.91
209_D214_K1.3950.91
195_L206_I1.3840.90
148_L171_Y1.3780.90
6_H77_A1.3740.90
71_R78_T1.3700.90
58_I177_R1.3580.90
55_E177_R1.3460.89
32_F36_V1.3290.89
114_H118_P1.3200.88
49_L101_H1.3150.88
170_G177_R1.3150.88
85_A228_V1.3130.88
67_L242_L1.3110.88
22_T183_L1.2930.87
41_T181_S1.2910.87
132_S136_L1.2890.87
143_G219_D1.2860.87
3_F79_L1.2750.86
246_A250_A1.2730.86
150_L154_L1.2640.86
42_A158_I1.2360.85
99_I182_Q1.2350.85
202_Q206_I1.2240.84
167_L231_R1.2080.83
27_V30_S1.2080.83
162_G188_N1.2080.83
190_I194_L1.2070.83
177_R183_L1.2020.83
155_A159_Y1.1990.83
36_V78_T1.1800.82
163_V239_Q1.1780.82
233_L237_L1.1730.81
27_V102_F1.1660.81
2_T5_I1.1590.81
37_L41_T1.1560.80
75_L214_K1.1550.80
36_V40_R1.1340.79
78_T81_T1.1280.79
58_I61_G1.1250.78
106_G233_L1.1220.78
217_E221_R1.1200.78
40_R195_L1.1170.78
96_S149_L1.1160.78
191_A198_F1.1080.77
237_L240_L1.1020.77
53_L69_D1.1000.77
95_F166_A1.0980.77
239_Q244_P1.0930.76
8_I32_F1.0920.76
161_V165_A1.0900.76
70_F242_L1.0870.76
243_V247_Y1.0840.76
206_I215_R1.0820.76
155_A203_L1.0820.76
44_M159_Y1.0760.75
94_L240_L1.0710.75
90_T131_P1.0690.75
17_I166_A1.0580.74
44_M158_I1.0570.74
140_R143_G1.0460.73
46_Q177_R1.0350.72
26_A152_N1.0340.72
62_A65_G1.0310.72
85_A232_L1.0300.72
74_I77_A1.0300.72
61_G136_L1.0290.72
51_A159_Y1.0290.72
32_F39_S1.0280.72
3_F7_L1.0240.72
209_D215_R1.0220.71
41_T81_T1.0220.71
40_R192_T1.0220.71
85_A95_F1.0170.71
236_L240_L1.0000.70
76_A109_P0.9910.69
34_I222_R0.9860.69
5_I21_R0.9840.68
164_L185_G0.9830.68
13_Y152_N0.9790.68
247_Y250_A0.9790.68
118_P125_R0.9760.68
55_E92_Q0.9760.68
173_N250_A0.9760.68
166_A181_S0.9650.67
83_L154_L0.9620.67
33_N192_T0.9580.66
83_L247_Y0.9570.66
30_S159_Y0.9520.66
23_G119_R0.9490.66
72_L76_A0.9480.66
180_A226_Y0.9470.65
166_A249_I0.9450.65
158_I194_L0.9440.65
11_L191_A0.9400.65
187_I248_L0.9330.64
24_R171_Y0.9300.64
156_T228_V0.9270.64
36_V232_L0.9270.64
83_L150_L0.9270.64
184_S192_T0.9270.64
27_V118_P0.9230.63
177_R181_S0.9140.63
159_Y185_G0.9100.62
78_T239_Q0.9090.62
112_L141_L0.9090.62
86_L97_R0.9020.62
31_L97_R0.9020.62
9_E40_R0.8990.61
56_T175_E0.8980.61
119_R123_R0.8940.61
236_L248_L0.8920.61
149_L161_V0.8910.61
83_L112_L0.8890.61
89_P152_N0.8860.60
20_V26_A0.8840.60
99_I195_L0.8830.60
108_V119_R0.8820.60
232_L238_A0.8760.59
100_E136_L0.8740.59
61_G83_L0.8740.59
63_L82_L0.8690.59
104_E114_H0.8680.59
42_A109_P0.8660.58
28_S160_T0.8500.57
74_I141_L0.8500.57
10_T228_V0.8490.57
185_G195_L0.8410.56
39_S48_P0.8390.56
162_G184_S0.8380.56
148_L206_I0.8350.56
100_E242_L0.8290.55
4_I193_I0.8260.55
116_F120_G0.8240.55
103_E145_P0.8200.54
23_G212_R0.8200.54
170_G183_L0.8180.54
154_L241_L0.8160.54
97_R104_E0.8150.54
221_R230_S0.8140.54
149_L230_S0.8110.54
78_T168_Y0.8080.53
115_G236_L0.8080.53
54_V78_T0.8080.53
66_L182_Q0.8050.53
35_L196_F0.8020.53
47_A179_T0.8020.53
99_I104_E0.8010.53
1_L17_I0.7970.52
38_V193_I0.7940.52
65_G116_F0.7920.52
44_M55_E0.7880.51
102_F183_L0.7870.51
54_V66_L0.7840.51
47_A163_V0.7820.51
82_L86_L0.7800.51
55_E185_G0.7800.51
173_N180_A0.7780.51
73_I135_N0.7750.50
31_L78_T0.7740.50
204_S208_D0.7720.50
178_V182_Q0.7700.50
66_L176_Y0.7690.50
50_L177_R0.7650.49
218_S236_L0.7620.49
226_Y229_G0.7590.49
80_G106_G0.7570.49
88_I228_V0.7560.48
223_M227_L0.7530.48
117_S120_G0.7460.48
230_S250_A0.7460.48
23_G142_R0.7430.47
213_G221_R0.7410.47
72_L164_L0.7410.47
75_L247_Y0.7390.47
55_E159_Y0.7390.47
144_I149_L0.7300.46
170_G228_V0.7290.46
242_L249_I0.7280.46
97_R101_H0.7180.45
83_L134_S0.7160.45
15_V36_V0.7120.44
12_A248_L0.7090.44
69_D170_G0.7080.44
19_G25_I0.7060.44
233_L250_A0.7060.44
30_S156_T0.7050.44
105_H108_V0.6970.43
86_L125_R0.6950.43
136_L156_T0.6910.43
172_L246_A0.6900.42
14_S91_F0.6880.42
99_I118_P0.6880.42
201_P208_D0.6840.42
215_R220_F0.6820.42
6_H41_T0.6810.42
148_L202_Q0.6800.42
155_A199_I0.6750.41
64_A83_L0.6740.41
198_F202_Q0.6730.41
23_G57_A0.6730.41
222_R231_R0.6660.40
182_Q185_G0.6650.40
10_T41_T0.6650.40
89_P169_A0.6630.40
15_V78_T0.6620.40
124_I187_I0.6600.40
156_T160_T0.6600.40
103_E223_M0.6600.40
189_G192_T0.6600.40
101_H104_E0.6600.40
131_P184_S0.6550.39
37_L107_S0.6520.39
173_N176_Y0.6500.39
18_A99_I0.6490.39
88_I160_T0.6480.39
149_L153_V0.6460.39
30_S34_I0.6450.39
32_F35_L0.6440.38
166_A171_Y0.6440.38
126_K154_L0.6430.38
104_E137_K0.6430.38
34_I233_L0.6420.38
63_L67_L0.6380.38
129_R138_G0.6360.38
161_V180_A0.6340.38
123_R193_I0.6340.38
209_D216_S0.6280.37
36_V161_V0.6270.37
36_V39_S0.6270.37
98_A248_L0.6270.37
45_F92_Q0.6250.37
92_Q177_R0.6230.37
123_R136_L0.6220.37
92_Q179_T0.6210.36
67_L98_A0.6200.36
52_K111_L0.6180.36
6_H10_T0.6180.36
104_E110_R0.6150.36
198_F204_S0.6100.36
56_T60_S0.6090.35
2_T7_L0.6060.35
11_L91_F0.6050.35
76_A211_V0.6020.35
147_R151_L0.5980.35
24_R213_G0.5970.34
58_I247_Y0.5970.34
128_I216_S0.5960.34
87_L110_R0.5950.34
114_H123_R0.5950.34
121_L130_L0.5930.34
170_G178_V0.5930.34
50_L195_L0.5920.34
104_E118_P0.5910.34
155_A224_V0.5890.34
46_Q194_L0.5880.34
234_G239_Q0.5880.34
233_L247_Y0.5870.34
71_R75_L0.5860.34
1_L20_V0.5840.33
167_L170_G0.5830.33
15_V35_L0.5770.33
44_M51_A0.5770.33
51_A223_M0.5760.33
206_I219_D0.5730.32
75_L232_L0.5730.32
135_N195_L0.5720.32
75_L193_I0.5700.32
9_E53_L0.5690.32
74_I161_V0.5680.32
114_H120_G0.5670.32
99_I135_N0.5610.32
167_L249_I0.5600.31
8_I11_L0.5600.31
247_Y251_W0.5580.31
82_L154_L0.5570.31
51_A155_A0.5550.31
113_L126_K0.5530.31
220_F223_M0.5530.31
219_D223_M0.5490.31
83_L141_L0.5490.31
32_F200_D0.5450.30
60_S116_F0.5420.30
58_I191_A0.5420.30
167_L182_Q0.5420.30
222_R225_V0.5420.30
37_L46_Q0.5410.30
133_L236_L0.5410.30
248_L251_W0.5380.30
221_R231_R0.5380.30
240_L247_Y0.5350.29
240_L251_W0.5340.29
186_V193_I0.5330.29
18_A127_S0.5330.29
49_L95_F0.5260.29
27_V125_R0.5260.29
165_A169_A0.5260.29
38_V84_G0.5260.29
141_L243_V0.5250.29
54_V167_L0.5240.29
129_R132_S0.5240.29
48_P179_T0.5240.29
70_F73_I0.5230.29
57_A99_I0.5220.29
13_Y162_G0.5220.29
112_L165_A0.5220.29
71_R80_G0.5200.28
26_A200_D0.5190.28
95_F212_R0.5150.28
74_I167_L0.5140.28
49_L103_E0.5120.28
25_I70_F0.5100.28
148_L159_Y0.5100.28
50_L77_A0.5090.28
92_Q106_G0.5070.27
153_V230_S0.5070.27
9_E159_Y0.5040.27
209_D220_F0.5030.27
9_E18_A0.5030.27
103_E158_I0.5020.27
81_T231_R0.5020.27
203_L216_S0.5010.27
194_L197_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9249 23.7 0.962 Contact Map
3w4tA 1 0.9407 20.7 0.963 Contact Map
4humA 1 0.9565 17.4 0.964 Contact Map
3mktA 1 0.9289 8.1 0.969 Contact Map
1pw4A 1 0.834 6.5 0.971 Contact Map
4jifB 1 0.0751 5.8 0.971 Contact Map
3wdoA 1 0.8379 4.3 0.973 Contact Map
3klyA 3 0.4506 3.4 0.974 Contact Map
3kcuA 3 0.4269 3 0.975 Contact Map
4u4vA 1 0.336 2.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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