GREMLIN Database
DUF2818 - Protein of unknown function (DUF2818)
PFAM: PF10993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (92)
Sequences: 1529 (989)
Seq/√Len: 103.1
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_Y74_T4.7871.00
8_L52_L3.2771.00
54_L63_I3.1881.00
23_F44_V2.9861.00
43_V75_A2.5001.00
22_L28_L2.4201.00
42_L79_L2.2841.00
47_F50_G2.1921.00
34_S37_W2.1691.00
9_A50_G2.1521.00
43_V47_F2.1031.00
12_A45_L1.8961.00
19_N24_G1.8871.00
10_L81_F1.8761.00
83_F91_L1.7581.00
33_K41_E1.6691.00
22_L37_W1.6421.00
55_L58_A1.5721.00
67_G73_V1.5341.00
9_A49_V1.5071.00
17_F82_A1.4751.00
80_V87_V1.3530.99
36_W40_L1.3230.99
23_F45_L1.3230.99
66_Q71_Y1.3160.99
20_E38_R1.2800.99
35_L39_L1.2600.99
17_F59_R1.2230.99
24_G28_L1.2070.99
46_Y78_F1.2050.99
24_G45_L1.1600.98
54_L58_A1.1600.98
51_G54_L1.1500.98
83_F86_F1.1310.98
12_A78_F1.1250.98
60_A64_A1.1110.98
88_Y92_L1.0870.97
68_W72_A1.0840.97
62_Q80_V1.0800.97
38_R90_Y1.0790.97
42_L75_A1.0740.97
20_E89_R1.0670.97
41_E57_E1.0630.97
46_Y50_G1.0470.97
10_L58_A0.9910.96
54_L71_Y0.9880.96
55_L59_R0.9620.95
87_V91_L0.9580.95
11_V18_L0.9480.94
48_L52_L0.9360.94
28_L31_A0.9250.94
54_L64_A0.8940.92
72_A76_C0.8890.92
8_L49_V0.8890.92
23_F55_L0.8800.92
83_F87_V0.8680.91
51_G63_I0.8590.91
26_I30_R0.8560.91
17_F87_V0.8510.91
50_G74_T0.8360.90
35_L90_Y0.8350.90
18_L21_R0.8210.89
3_W7_L0.8130.88
47_F51_G0.8020.88
58_A92_L0.8010.88
34_S38_R0.7950.87
77_L81_F0.7950.87
61_G66_Q0.7930.87
80_V92_L0.7820.86
53_G74_T0.7760.86
5_V53_G0.7690.85
17_F24_G0.7620.85
49_V56_L0.7620.85
78_F85_G0.7570.85
76_C80_V0.7310.82
66_Q77_L0.7240.82
13_A16_P0.7210.82
61_G69_E0.7100.81
11_V24_G0.7080.80
61_G73_V0.7020.80
49_V73_V0.7010.80
51_G55_L0.7010.80
6_L46_Y0.6980.80
4_L56_L0.6830.78
24_G37_W0.6680.76
87_V92_L0.6670.76
68_W76_C0.6660.76
76_C79_L0.6640.76
64_A73_V0.6510.75
67_G72_A0.6510.75
76_C92_L0.6470.74
38_R53_G0.6450.74
34_S40_L0.6390.73
57_E70_F0.6380.73
3_W93_K0.6360.73
8_L12_A0.6330.73
37_W40_L0.6310.72
42_L83_F0.6280.72
35_L62_Q0.6220.71
50_G81_F0.6140.70
20_E32_P0.6120.70
53_G88_Y0.6110.70
49_V54_L0.6110.70
18_L45_L0.6080.70
72_A75_A0.6030.69
41_E70_F0.6020.69
53_G64_A0.6010.69
62_Q65_P0.5940.68
66_Q70_F0.5930.68
2_V73_V0.5920.68
6_L71_Y0.5890.67
17_F83_F0.5860.67
50_G71_Y0.5810.66
3_W6_L0.5800.66
2_V6_L0.5720.65
4_L20_E0.5690.64
12_A49_V0.5690.64
6_L60_A0.5660.64
56_L59_R0.5610.63
85_G93_K0.5600.63
69_E78_F0.5600.63
75_A79_L0.5600.63
36_W88_Y0.5590.63
7_L63_I0.5440.61
18_L88_Y0.5390.60
17_F35_L0.5380.60
35_L91_L0.5350.60
59_R62_Q0.5310.59
45_L78_F0.5260.58
6_L59_R0.5250.58
79_L86_F0.5210.58
19_N22_L0.5130.57
26_I37_W0.5120.56
4_L8_L0.5100.56
80_V83_F0.5060.56
5_V77_L0.5040.55
14_N71_Y0.5040.55
3_W11_V0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.9677 6.7 0.93 Contact Map
4tllB 2 0.2688 4.1 0.937 Contact Map
4aw6A 2 0.9355 3.1 0.941 Contact Map
3ixzA 1 0.957 2.6 0.943 Contact Map
2zxeA 1 0.9355 2.6 0.943 Contact Map
4u2pA 4 0.2473 2.1 0.946 Contact Map
4twkA 2 0.3441 2.1 0.946 Contact Map
1fftB 1 0.4301 1.6 0.949 Contact Map
2fyuK 1 0.4194 1.4 0.951 Contact Map
3ar4A 1 0.9247 1.3 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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