GREMLIN Database
DUF2809 - Protein of unknown function (DUF2809)
PFAM: PF10990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (83)
Sequences: 7033 (5412)
Seq/√Len: 594.0
META: 0.878

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_L44_F2.7651.00
67_R72_S2.6891.00
53_H58_L2.5471.00
24_R35_I2.5441.00
44_F83_A2.1451.00
30_A34_R2.0801.00
50_Q78_D1.9881.00
16_A43_A1.8961.00
63_T66_G1.8701.00
64_T67_R1.7551.00
44_F79_L1.7421.00
40_L83_A1.7301.00
7_R10_L1.7291.00
13_A84_V1.6471.00
19_V39_A1.5941.00
4_G8_K1.5691.00
64_T68_L1.5231.00
53_H56_W1.5051.00
16_A86_I1.4931.00
56_W61_R1.4851.00
54_A58_L1.4641.00
45_A49_S1.4531.00
22_L26_L1.4371.00
23_V42_F1.4241.00
48_F52_Y1.4201.00
30_A35_I1.4151.00
10_L13_A1.3091.00
13_A81_A1.2891.00
29_R34_R1.2561.00
52_Y57_L1.2281.00
15_W19_V1.2201.00
31_S34_R1.2151.00
15_W43_A1.2111.00
30_A33_L1.2031.00
9_Y81_A1.1941.00
18_M22_L1.1911.00
27_F30_A1.1711.00
54_A57_L1.1541.00
72_S75_S1.1491.00
76_W79_L1.1471.00
77_S81_A1.1421.00
19_V42_F1.0971.00
60_L66_G1.0901.00
9_Y77_S1.0861.00
76_W80_L1.0511.00
20_Y32_L1.0291.00
17_I21_L1.0291.00
19_V43_A1.0151.00
23_V35_I0.9881.00
36_A86_I0.9841.00
57_L61_R0.9751.00
49_S58_L0.9741.00
49_S54_A0.9461.00
65_L69_V0.9401.00
49_S52_Y0.8971.00
41_L45_A0.8951.00
5_F10_L0.8841.00
44_F48_F0.8721.00
42_F46_V0.8611.00
59_G63_T0.8501.00
55_P70_L0.8491.00
30_A38_A0.8491.00
43_A46_V0.8421.00
63_T68_L0.8331.00
75_S79_L0.8271.00
53_H57_L0.8141.00
77_S80_L0.7981.00
32_L35_I0.7941.00
38_A42_F0.7581.00
20_Y24_R0.7551.00
15_W46_V0.7541.00
48_F51_L0.7491.00
22_L25_L0.7201.00
40_L86_I0.6891.00
27_F35_I0.6861.00
32_L36_A0.6821.00
20_Y36_A0.6791.00
19_V46_V0.6701.00
8_K12_D0.6621.00
79_L83_A0.6591.00
6_I10_L0.6541.00
52_Y56_W0.6541.00
55_P59_G0.6541.00
8_K75_S0.6481.00
62_A67_R0.6431.00
57_L60_L0.6431.00
54_A70_L0.6401.00
39_A86_I0.6401.00
24_R28_P0.6311.00
23_V38_A0.6231.00
37_L41_L0.6221.00
40_L79_L0.6171.00
27_F34_R0.6121.00
24_R32_L0.6101.00
15_W49_S0.6091.00
24_R30_A0.6041.00
38_A41_L0.6001.00
29_R33_L0.6001.00
57_L70_L0.5991.00
16_A39_A0.5961.00
53_H72_S0.5851.00
24_R27_F0.5811.00
33_L36_A0.5781.00
60_L63_T0.5751.00
81_A85_G0.5631.00
81_A84_V0.5611.00
61_R66_G0.5590.99
65_L68_L0.5530.99
25_L29_R0.5520.99
18_M21_L0.5460.99
24_R31_S0.5440.99
12_D46_V0.5430.99
14_L17_I0.5410.99
67_R73_G0.5370.99
73_G77_S0.5360.99
10_L81_A0.5350.99
48_F79_L0.5310.99
52_Y58_L0.5230.99
36_A39_A0.5190.99
75_S81_A0.5070.99
50_Q73_G0.5040.99
50_Q65_L0.5030.99
47_E50_Q0.5020.99
14_L18_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m5bA 1 0.9884 2.1 0.924 Contact Map
2jm6A 1 0.314 1.9 0.926 Contact Map
2gqrA 2 0.3372 1.4 0.931 Contact Map
1sv0C 1 0.3256 1.4 0.931 Contact Map
1wf6A 1 0.3372 1.4 0.932 Contact Map
3j9pD 4 0.686 1.4 0.932 Contact Map
4k0jA 3 0.7674 1.1 0.935 Contact Map
4p6vB 1 0.8953 1 0.937 Contact Map
3rceA 1 0.9302 1 0.937 Contact Map
2mnsA 1 0.1163 1 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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