GREMLIN Database
DUF2796 - Protein of unknown function (DUF2796)
PFAM: PF10986 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 167 (161)
Sequences: 1867 (1542)
Seq/√Len: 121.5
META: 0.77

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_H42_Q3.7681.00
4_E7_V3.3361.00
151_L158_G3.2761.00
25_S29_N3.2601.00
8_A144_L2.7311.00
39_T42_Q2.7261.00
31_V49_A2.6521.00
8_A147_I2.5791.00
11_N22_E2.5221.00
11_N150_Q2.5061.00
14_L19_L2.4461.00
8_A25_S2.2921.00
70_L122_F2.1761.00
18_T121_Q2.0861.00
55_D58_A2.0511.00
28_A143_G2.0221.00
25_S30_L1.9851.00
52_Q140_A1.9621.00
27_A116_F1.9111.00
30_L49_A1.9021.00
67_G126_N1.8891.00
137_L144_L1.8661.00
19_L62_L1.8451.00
44_A48_A1.8161.00
56_P70_L1.7941.00
9_E24_E1.6781.00
29_N143_G1.6741.00
7_V146_K1.6731.00
29_N144_L1.6361.00
24_E117_H1.6061.00
135_V162_L1.5821.00
8_A29_N1.5521.00
126_N129_A1.5261.00
50_L54_E1.5051.00
21_I60_F1.4891.00
136_G139_K1.4671.00
45_A49_A1.4521.00
20_E119_E1.4501.00
146_K161_E1.4341.00
59_L140_A1.4201.00
8_A23_L1.4181.00
92_H98_D1.3931.00
57_L122_F1.3721.00
66_A127_P1.3671.00
30_L141_F1.3641.00
138_F144_L1.3271.00
8_A137_L1.3231.00
10_L23_L1.2821.00
19_L130_L1.2631.00
77_S80_L1.2440.99
68_C124_C1.2290.99
39_T43_K1.2230.99
43_K47_A1.2180.99
47_A51_A1.2160.99
27_A114_S1.2020.99
12_I133_I1.2000.99
72_S121_Q1.1960.99
61_V134_D1.1870.99
37_P43_K1.1730.99
150_Q159_A1.1680.99
63_P66_A1.1450.99
19_L122_F1.1300.99
67_G125_A1.1290.99
127_P130_L1.1180.99
31_V116_F1.1090.99
56_P120_Y1.1070.99
37_P42_Q1.1070.99
17_N123_T1.0970.99
152_I156_G1.0950.99
71_T121_Q1.0940.99
15_E18_T1.0900.99
42_Q45_A1.0750.98
45_A48_A1.0640.98
27_A115_D1.0630.98
93_H99_E1.0430.98
95_H98_D1.0410.98
47_A50_L1.0310.98
31_V115_D1.0180.98
37_P79_L1.0180.98
7_V148_E1.0120.98
40_D44_A1.0110.98
66_A130_L1.0100.98
69_K123_T1.0090.98
37_P77_S1.0000.97
23_L144_L0.9960.97
50_L116_F0.9890.97
146_K163_T0.9800.97
61_V136_G0.9770.97
9_E148_E0.9720.97
3_H6_G0.9720.97
22_E117_H0.9660.97
71_T123_T0.9620.97
63_P132_S0.9570.97
49_A141_F0.9460.96
139_K142_P0.9450.96
134_D167_P0.9290.96
40_D43_K0.9170.96
48_A52_Q0.9160.96
137_L147_I0.9150.96
52_Q58_A0.9120.96
60_F120_Y0.9100.96
75_V78_P0.9070.96
13_A26_P0.9000.95
94_D98_D0.9000.95
95_H99_E0.8940.95
27_A141_F0.8870.95
97_H101_D0.8860.95
60_F133_I0.8840.95
70_L73_A0.8840.95
135_V139_K0.8820.95
11_N151_L0.8760.95
14_L130_L0.8750.95
53_L116_F0.8710.94
136_G140_A0.8520.94
148_E152_I0.8500.94
144_L147_I0.8450.93
25_S144_L0.8440.93
31_V46_V0.8440.93
42_Q157_Q0.8270.93
151_L160_A0.8240.93
10_L21_I0.8220.93
57_L70_L0.8060.92
16_G127_P0.7970.91
138_F147_I0.7920.91
87_D101_D0.7850.91
77_S114_S0.7780.90
11_N24_E0.7780.90
77_S116_F0.7760.90
96_D99_E0.7750.90
56_P122_F0.7720.90
33_F46_V0.7680.90
46_V79_L0.7680.90
69_K125_A0.7620.89
30_L116_F0.7520.89
23_L147_I0.7520.89
62_L130_L0.7510.89
50_L80_L0.7450.88
160_A167_P0.7440.88
25_S141_F0.7430.88
94_D105_D0.7320.87
135_V160_A0.7290.87
37_P142_P0.7190.86
59_L120_Y0.7170.86
41_A145_E0.7140.86
25_S137_L0.7130.86
14_L127_P0.7050.85
67_G129_A0.7040.85
95_H101_D0.7010.85
76_E117_H0.7010.85
27_A75_V0.6980.85
20_E121_Q0.6970.85
37_P81_E0.6860.84
35_H157_Q0.6850.84
20_E146_K0.6840.84
60_F118_A0.6800.83
88_D105_D0.6790.83
94_D97_H0.6790.83
26_P29_N0.6770.83
148_E159_A0.6740.83
150_Q153_T0.6730.83
58_A64_A0.6690.82
88_D92_H0.6650.82
18_T123_T0.6610.82
149_V162_L0.6570.81
26_P30_L0.6570.81
35_H38_R0.6470.80
46_V78_P0.6470.80
152_I158_G0.6420.80
96_D100_H0.6380.79
92_H99_E0.6310.78
31_V45_A0.6230.78
62_L66_A0.6230.78
46_V114_S0.6210.77
22_E119_E0.6200.77
83_H86_H0.6160.77
11_N20_E0.6150.77
41_A45_A0.6150.77
56_P135_V0.6140.77
56_P59_L0.6120.76
75_V120_Y0.6110.76
13_A25_S0.6080.76
20_E27_A0.6050.76
137_L162_L0.5970.75
63_P131_T0.5970.75
14_L154_P0.5960.74
27_A137_L0.5910.74
10_L115_D0.5900.74
74_E119_E0.5860.73
97_H100_H0.5820.73
24_E115_D0.5800.72
82_D92_H0.5780.72
70_L133_I0.5750.72
23_L30_L0.5750.72
54_E155_K0.5740.72
93_H100_H0.5740.72
138_F164_P0.5740.72
151_L159_A0.5700.71
4_E136_G0.5660.71
23_L118_A0.5640.70
1_G4_E0.5620.70
49_A116_F0.5620.70
29_N137_L0.5610.70
30_L137_L0.5610.70
76_E81_E0.5600.70
52_Q139_K0.5520.69
85_D88_D0.5490.68
87_D92_H0.5490.68
92_H95_H0.5430.67
30_L135_V0.5430.67
153_T156_G0.5390.67
37_P46_V0.5390.67
29_N49_A0.5390.67
39_T46_V0.5370.67
66_A138_F0.5340.66
50_L75_V0.5320.66
20_E132_S0.5310.66
63_P130_L0.5310.66
79_L144_L0.5310.66
67_G80_L0.5290.65
62_L133_I0.5290.65
51_A139_K0.5270.65
94_D107_D0.5260.65
92_H106_H0.5250.65
107_D110_E0.5250.65
44_A74_E0.5220.64
86_H97_H0.5220.64
75_V80_L0.5210.64
94_D99_E0.5190.64
5_H113_H0.5190.64
35_H45_A0.5160.64
138_F141_F0.5120.63
40_D73_A0.5120.63
97_H106_H0.5110.63
163_T166_N0.5090.63
137_L140_A0.5080.62
93_H98_D0.5070.62
42_Q77_S0.5060.62
8_A14_L0.5040.62
23_L77_S0.5020.61
50_L150_Q0.5010.61
11_N152_I0.5010.61
50_L77_S0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zqjA 1 0.2814 22 0.933 Contact Map
4e4jA 4 0.1856 15.5 0.937 Contact Map
3uauA 1 0.2635 11.7 0.941 Contact Map
3lnsA 2 0.2695 10.2 0.942 Contact Map
4bxhA 3 0.2216 8.8 0.944 Contact Map
2f09A 1 0.2635 7.8 0.945 Contact Map
4s2rP 2 0.2874 6.8 0.947 Contact Map
4ujrH 1 0.3174 5.7 0.948 Contact Map
1k8wA 1 0.2635 5.4 0.949 Contact Map
2xz8A 2 0.2994 5.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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