GREMLIN Database
DUF2805 - Protein of unknown function (DUF2805)
PFAM: PF10985 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 71 (71)
Sequences: 4067 (1584)
Seq/√Len: 188.0
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_P42_K4.5121.00
61_P64_G2.9411.00
29_I41_F2.7111.00
36_L43_L2.5981.00
24_S27_E2.4881.00
9_E12_T2.3981.00
39_S43_L2.3941.00
25_E48_V2.1141.00
59_R63_V1.9571.00
18_E24_S1.9241.00
40_S43_L1.7891.00
19_F56_L1.7011.00
37_K40_S1.6051.00
33_R41_F1.5651.00
26_K29_I1.4911.00
11_R53_T1.4711.00
23_L31_L1.4611.00
39_S42_K1.4411.00
2_R5_E1.2771.00
2_R9_E1.2501.00
13_P56_L1.2201.00
16_A20_Q1.2151.00
68_C71_Q1.2101.00
14_F28_V1.2061.00
13_P16_A1.1961.00
5_E9_E1.1841.00
25_E29_I1.1801.00
60_S63_V1.1681.00
43_L46_K1.1311.00
1_D5_E1.0981.00
7_A28_V1.0441.00
26_K30_K1.0441.00
33_R38_P1.0030.99
50_G53_T0.9960.99
13_P21_F0.9900.99
1_D67_K0.9770.99
2_R11_R0.9730.99
6_M9_E0.9470.99
2_R6_M0.9400.99
37_K43_L0.9370.99
3_I23_L0.9260.99
67_K70_R0.9020.99
6_M12_T0.8850.99
52_K58_K0.8790.99
41_F49_S0.8780.99
15_E19_F0.8630.98
56_L59_R0.8580.98
2_R16_A0.8430.98
30_K34_R0.8390.98
29_I33_R0.8340.98
29_I49_S0.7990.97
2_R21_F0.7940.97
16_A19_F0.7930.97
61_P66_F0.7650.97
36_L48_V0.7560.96
42_K46_K0.7340.96
48_V51_R0.7300.96
67_K71_Q0.7150.95
6_M16_A0.7060.95
1_D66_F0.7050.95
18_E22_G0.7040.95
64_G69_S0.6960.94
4_I7_A0.6950.94
21_F31_L0.6940.94
59_R62_E0.6930.94
4_I36_L0.6920.94
16_A21_F0.6850.94
31_L35_E0.6780.94
15_E55_H0.6580.93
41_F44_W0.6400.92
44_W47_R0.6380.91
60_S64_G0.6380.91
12_T16_A0.6380.91
63_V66_F0.6330.91
15_E58_K0.6260.91
9_E53_T0.6110.90
1_D70_R0.6040.89
9_E21_F0.6000.89
23_L27_E0.5970.89
46_K49_S0.5950.88
40_S45_R0.5920.88
66_F69_S0.5910.88
53_T63_V0.5880.88
4_I35_E0.5870.88
66_F71_Q0.5780.87
8_W12_T0.5760.87
23_L35_E0.5690.86
6_M21_F0.5680.86
66_F70_R0.5450.84
19_F30_K0.5420.83
24_S28_V0.5410.83
64_G67_K0.5360.83
22_G57_K0.5360.83
15_E57_K0.5300.82
29_I48_V0.5280.82
2_R20_Q0.5270.82
41_F50_G0.5190.81
60_S67_K0.5180.80
36_L40_S0.5170.80
18_E28_V0.5100.79
62_E67_K0.5100.79
62_E70_R0.5080.79
10_D32_M0.5080.79
40_S47_R0.5040.79
37_K48_V0.5040.79
58_K64_G0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l0oC 1 0 29.5 0.885 Contact Map
2q1zA 1 0.6056 23.2 0.89 Contact Map
4ch7A 1 0.9437 20.5 0.893 Contact Map
2o8xA 7 0.5775 20.3 0.893 Contact Map
2x48A 1 0.4648 20.1 0.894 Contact Map
1u78A 1 0.9155 19.3 0.895 Contact Map
3hugA 3 0.7042 19.3 0.895 Contact Map
4nqwA 1 0.6197 19.3 0.895 Contact Map
2a6hF 1 0.6901 19.1 0.895 Contact Map
4aybH 1 0.6197 18.6 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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