GREMLIN Database
DUF2794 - Protein of unknown function (DUF2794)
PFAM: PF10984 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (85)
Sequences: 4350 (1607)
Seq/√Len: 174.3
META: 0.926

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_N13_N3.4801.00
35_R55_R3.3781.00
30_D39_S3.1871.00
59_A64_A2.5601.00
40_V52_I2.4191.00
2_F31_F2.4191.00
35_R53_E2.3831.00
18_M21_A2.2051.00
67_V84_V2.1971.00
18_M23_E2.1001.00
6_R9_N2.0691.00
42_R46_E2.0361.00
10_R82_A2.0071.00
37_V51_R1.8371.00
69_G73_Q1.7621.00
32_L37_V1.7551.00
17_R21_A1.7351.00
55_R66_A1.7061.00
18_M24_W1.6951.00
80_D83_Q1.6741.00
8_L12_L1.6331.00
19_V24_W1.6231.00
16_G20_A1.4531.00
47_R70_A1.4521.00
56_P63_G1.4121.00
24_W40_V1.4031.00
40_V49_L1.4011.00
25_R43_R1.3161.00
10_R13_N1.3121.00
4_D9_N1.2761.00
58_L62_Q1.2281.00
23_E49_L1.1591.00
25_R46_E1.1061.00
5_R9_N1.0941.00
24_W50_Y1.0641.00
40_V67_V1.0631.00
32_L39_S1.0320.99
6_R10_R1.0230.99
40_V50_Y0.9950.99
15_Y54_K0.9780.99
79_H83_Q0.9620.99
70_A73_Q0.9610.99
32_L35_R0.9180.99
55_R58_L0.9120.99
41_F45_S0.8720.98
30_D37_V0.8640.98
2_F36_A0.8590.98
4_D18_M0.8200.97
15_Y22_G0.8160.97
56_P62_Q0.8130.97
78_G84_V0.8030.97
75_L79_H0.8020.97
63_G79_H0.7900.97
74_I77_R0.7900.97
58_L64_A0.7880.97
22_G54_K0.7750.96
4_D10_R0.7740.96
58_L63_G0.7730.96
20_A43_R0.7650.96
15_Y19_V0.7640.96
31_F36_A0.7610.96
62_Q67_V0.7350.95
67_V83_Q0.7290.95
52_I67_V0.7290.95
3_F11_I0.7220.94
3_F7_E0.7170.94
28_A31_F0.7120.94
50_Y67_V0.7060.94
4_D11_I0.7030.94
49_L70_A0.7010.93
32_L60_R0.6960.93
28_A36_A0.6960.93
10_R14_L0.6900.93
55_R68_I0.6690.92
10_R81_L0.6680.92
60_R64_A0.6670.92
11_I56_P0.6670.92
31_F50_Y0.6650.92
40_V46_E0.6630.91
62_Q75_L0.6580.91
2_F13_N0.6580.91
39_S51_R0.6580.91
16_G29_I0.6490.91
2_F8_L0.6460.90
37_V53_E0.6370.90
60_R63_G0.6360.90
14_L18_M0.6360.90
13_N31_F0.6260.89
7_E54_K0.6260.89
7_E15_Y0.6210.89
31_F60_R0.6160.88
49_L52_I0.6150.88
52_I62_Q0.6110.88
42_R51_R0.6060.87
79_H82_A0.6040.87
53_E56_P0.6030.87
9_N34_D0.6030.87
36_A39_S0.6010.87
11_I52_I0.5970.87
16_G72_G0.5950.86
46_E53_E0.5910.86
35_R74_I0.5900.86
73_Q83_Q0.5900.86
27_Y38_F0.5880.86
13_N25_R0.5870.86
23_E50_Y0.5870.86
12_L29_I0.5840.85
11_I18_M0.5810.85
16_G42_R0.5620.83
33_R64_A0.5540.82
62_Q79_H0.5520.82
2_F17_R0.5510.82
26_D44_A0.5500.82
82_A85_L0.5500.82
47_R51_R0.5450.81
34_D42_R0.5430.81
10_R33_R0.5430.81
59_A62_Q0.5360.80
19_V54_K0.5350.80
45_S60_R0.5320.80
36_A43_R0.5260.79
51_R68_I0.5260.79
64_A77_R0.5240.79
72_G80_D0.5140.77
28_A47_R0.5060.76
39_S44_A0.5040.76
23_E48_P0.5020.76
75_L78_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k8eA 1 0.4353 27.8 0.901 Contact Map
4o0aA 1 0.7412 19.6 0.908 Contact Map
3j20F 1 0.6 11.4 0.917 Contact Map
3l4gA 2 0.9882 10.9 0.918 Contact Map
1ofdA 1 0.9765 9 0.921 Contact Map
3gd5A 4 0.8 7.4 0.924 Contact Map
1vlvA 6 0.9647 7.3 0.924 Contact Map
3r7fA 3 0.9176 6.4 0.926 Contact Map
1q98A 2 0.9647 6.4 0.926 Contact Map
3grfA 3 0.8353 6.3 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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