GREMLIN Database
DUF2793 - Protein of unknown function (DUF2793)
PFAM: PF10983 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (86)
Sequences: 6685 (5493)
Seq/√Len: 592.3
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_H50_Q4.0621.00
17_E73_E2.6201.00
40_A48_D2.4821.00
47_H61_F2.4201.00
69_R78_L2.2141.00
17_E32_D2.1411.00
72_V75_E2.1221.00
18_S21_L2.1001.00
19_R79_L2.0201.00
19_R75_E2.0101.00
65_R68_W1.8971.00
52_A61_F1.8841.00
14_L70_A1.8631.00
72_V79_L1.8071.00
10_A53_A1.7961.00
33_R53_A1.7911.00
8_L12_V1.6361.00
16_V35_I1.5931.00
53_A62_L1.5651.00
1_H5_L1.5441.00
28_P54_W1.5131.00
50_Q61_F1.4791.00
16_V70_A1.4331.00
50_Q63_T1.4221.00
55_Q60_R1.3401.00
22_T37_G1.2581.00
69_R80_V1.2451.00
29_A32_D1.2321.00
15_A73_E1.2141.00
7_R62_L1.2041.00
33_R51_I1.1801.00
1_H4_A1.0871.00
30_E55_Q1.0741.00
17_E34_Y1.0721.00
36_V40_A1.0651.00
30_E57_G1.0601.00
6_R56_D1.0171.00
37_G40_A1.0031.00
19_R72_V1.0021.00
34_Y44_W0.9881.00
22_T40_A0.9741.00
75_E79_L0.9631.00
30_E56_D0.9601.00
49_G81_F0.9591.00
36_V61_F0.9491.00
82_D85_A0.9451.00
20_D37_G0.9311.00
23_A41_T0.9111.00
15_A33_R0.8971.00
19_R35_I0.8871.00
64_P68_W0.8851.00
24_P44_W0.8841.00
30_E54_W0.8821.00
6_R60_R0.8811.00
35_I70_A0.8761.00
24_P36_V0.8751.00
71_W78_L0.8711.00
66_E73_E0.8681.00
36_V52_A0.8611.00
4_A9_D0.8541.00
53_A60_R0.8521.00
66_E84_G0.8411.00
37_G48_D0.8361.00
66_E76_G0.8341.00
18_S74_D0.8331.00
39_G48_D0.8311.00
6_R55_Q0.8301.00
14_L51_I0.8211.00
66_E81_F0.8161.00
62_L68_W0.7961.00
38_A49_G0.7931.00
14_L33_R0.7871.00
20_D75_E0.7851.00
24_P43_A0.7751.00
47_H52_A0.7751.00
16_V72_V0.7671.00
25_P28_P0.7671.00
13_Q68_W0.7551.00
64_P81_F0.7351.00
21_L34_Y0.7201.00
66_E71_W0.7111.00
36_V48_D0.6841.00
55_Q58_A0.6841.00
5_L9_D0.6801.00
11_L62_L0.6731.00
66_E82_D0.6711.00
54_W58_A0.6621.00
7_R60_R0.6601.00
24_P40_A0.6601.00
22_T48_D0.6591.00
3_E6_R0.6581.00
16_V19_R0.6551.00
7_R11_L0.6511.00
71_W80_V0.6461.00
42_G45_A0.6451.00
1_H6_R0.6451.00
16_V33_R0.6401.00
21_L25_P0.6291.00
21_L37_G0.6281.00
36_V47_H0.6271.00
10_A62_L0.6251.00
21_L44_W0.6201.00
3_E7_R0.6131.00
36_V44_W0.6101.00
30_E58_A0.6101.00
24_P37_G0.6091.00
51_I70_A0.6011.00
2_N9_D0.5901.00
76_G82_D0.5901.00
38_A48_D0.5841.00
14_L69_R0.5821.00
33_R70_A0.5771.00
3_E60_R0.5751.00
18_S72_V0.5590.99
22_T39_G0.5530.99
35_I79_L0.5480.99
44_W59_W0.5480.99
66_E83_G0.5480.99
46_G61_F0.5460.99
19_R74_D0.5440.99
65_R81_F0.5420.99
1_H7_R0.5400.99
20_D74_D0.5290.99
35_I81_F0.5210.99
47_H63_T0.5170.99
18_S34_Y0.5150.99
23_A42_G0.5110.99
18_S37_G0.5070.99
6_R9_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hshA 7 0.5057 12.3 0.893 Contact Map
3n3fA 3 0.4828 9.3 0.899 Contact Map
2dl1A 1 0.3448 7.5 0.903 Contact Map
2av4A 3 0.3218 5 0.91 Contact Map
4tvcA 1 0.3908 4.5 0.912 Contact Map
4dnyA 1 1 4.5 0.912 Contact Map
1cvrA 1 0.6092 4.2 0.913 Contact Map
4mhcA 1 0.7931 4.2 0.913 Contact Map
3hlzA 1 0.4713 4.2 0.913 Contact Map
4hz9A 1 0.8966 3.9 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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