GREMLIN Database
DUF2788 - Protein of unknown function (DUF2788)
PFAM: PF10981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (50)
Sequences: 1226 (460)
Seq/√Len: 65.1
META: 0.816

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D19_E4.1341.00
13_I30_L3.5081.00
14_W18_K2.3941.00
17_A27_T2.1981.00
45_G48_Q1.8671.00
32_L36_L1.6380.99
3_G7_L1.5510.99
43_A47_I1.5130.99
13_I35_G1.5030.99
37_G40_G1.4820.98
8_Y11_F1.3900.98
15_D18_K1.3880.98
40_G47_I1.3840.98
25_F29_V1.3620.97
8_Y15_D1.3560.97
28_F32_L1.3390.97
45_G49_W1.2930.96
10_L38_M1.2480.95
46_V50_F1.2380.95
14_W31_F1.1960.94
7_L11_F1.1850.94
33_V36_L1.1570.93
22_A26_G1.1500.93
6_I38_M1.1380.93
4_G7_L1.0670.90
33_V45_G1.0470.89
17_A21_K0.9790.86
13_I38_M0.9490.84
25_F28_F0.9430.83
20_S31_F0.8820.79
39_L42_V0.8680.78
1_G32_L0.8380.76
6_I9_M0.8360.75
39_L43_A0.8240.74
12_I17_A0.8230.74
42_V45_G0.8150.73
21_K31_F0.7890.71
1_G4_G0.7830.70
10_L33_V0.7750.70
12_I23_G0.7730.69
8_Y19_E0.7530.67
2_V41_F0.7490.67
41_F45_G0.7360.66
36_L39_L0.7280.65
22_A27_T0.7280.65
35_G38_M0.7210.64
16_L23_G0.7150.63
35_G39_L0.6930.61
24_K28_F0.6520.56
10_L35_G0.6510.56
42_V50_F0.6450.56
12_I27_T0.6430.55
12_I16_L0.6420.55
32_L46_V0.6340.54
23_G30_L0.6170.52
29_V32_L0.6120.52
5_L9_M0.6090.51
17_A20_S0.5990.50
12_I30_L0.5930.50
24_K34_L0.5880.49
18_K33_V0.5850.49
6_I40_G0.5730.47
14_W27_T0.5700.47
4_G17_A0.5680.47
12_I31_F0.5570.45
29_V46_V0.5530.45
37_G47_I0.5490.44
9_M40_G0.5350.43
20_S25_F0.5340.43
2_V5_L0.5250.42
17_A23_G0.5180.41
1_G5_L0.5110.40
2_V36_L0.5080.40
2_V28_F0.5030.39
32_L39_L0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w1kA 1 0 7.6 0.87 Contact Map
1afoA 2 0.3725 4.2 0.885 Contact Map
4cbfA 7 0.7451 3.1 0.892 Contact Map
3j27A 7 0.7451 2.9 0.894 Contact Map
4cctA 7 0.7451 2.9 0.894 Contact Map
2k21A 1 1 2.8 0.895 Contact Map
2ph5A 2 0.549 2.7 0.895 Contact Map
4plpA 2 0.5686 1.6 0.907 Contact Map
3hunA 1 0 1.6 0.908 Contact Map
1wazA 1 0.451 1.6 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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