GREMLIN Database
DUF2785 - Protein of unknown function (DUF2785)
PFAM: PF10978 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 174 (171)
Sequences: 1989 (1523)
Seq/√Len: 116.4
META: 0.782

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A77_L4.3671.00
7_E10_T3.4881.00
78_L95_I3.1251.00
30_D84_N2.6651.00
14_F65_K2.6621.00
11_D65_K2.6571.00
52_L118_L2.4831.00
69_H72_A2.4631.00
62_D68_A2.4401.00
92_L130_D2.4041.00
18_F69_H2.3731.00
88_D91_D2.3641.00
82_A125_I2.2631.00
14_F68_A2.2041.00
92_L125_I2.1811.00
96_L122_V2.1591.00
42_R91_D2.0661.00
13_V68_A2.0381.00
50_A54_A2.0241.00
18_F73_H1.9381.00
18_F21_L1.9361.00
93_A135_E1.8931.00
109_V112_H1.8271.00
37_S40_E1.8171.00
132_D135_E1.8021.00
99_I118_L1.7021.00
27_A44_L1.6941.00
24_A80_Q1.6381.00
122_V168_F1.6251.00
79_K124_S1.6151.00
72_A76_D1.6101.00
52_L74_G1.5751.00
140_L172_L1.5731.00
115_D167_N1.5641.00
46_D94_R1.5461.00
116_E166_K1.5431.00
30_D86_A1.5101.00
14_F62_D1.4811.00
20_A77_L1.4631.00
29_R35_F1.4611.00
112_H156_P1.4581.00
93_A131_L1.4341.00
62_D65_K1.4321.00
65_K68_A1.4321.00
76_D117_R1.4001.00
40_E43_A1.3991.00
6_G12_S1.3601.00
149_W152_A1.3501.00
51_Y74_G1.3341.00
92_L128_R1.3151.00
44_L77_L1.3141.00
4_G12_S1.3131.00
89_K93_A1.3041.00
42_R46_D1.2941.00
97_D142_R1.2830.99
80_Q83_R1.2570.99
45_L95_I1.2490.99
25_E28_R1.2300.99
31_R85_P1.2280.99
38_A86_A1.2140.99
159_L163_H1.2120.99
25_E80_Q1.2120.99
26_I35_F1.2120.99
28_R80_Q1.1850.99
45_L49_L1.1790.99
17_S20_A1.1740.99
15_R19_S1.1390.99
69_H73_H1.1220.99
166_K170_R1.1190.99
75_A118_L1.1160.99
79_K120_R1.1060.98
31_R84_N1.1050.98
29_R32_K1.0990.98
116_E170_R1.0950.98
21_L73_H1.0920.98
58_L70_A1.0920.98
161_R165_T1.0910.98
55_E74_G1.0860.98
69_H117_R1.0810.98
163_H167_N1.0700.98
55_E70_A1.0630.98
4_G7_E1.0610.98
133_E137_E1.0390.98
78_L99_I1.0380.98
100_A139_W1.0300.98
31_R80_Q1.0120.97
158_G161_R1.0040.97
120_R124_S1.0010.97
45_L91_D0.9990.97
11_D14_F0.9870.97
38_A88_D0.9780.97
60_G69_H0.9770.97
29_R33_A0.9760.97
149_W158_G0.9720.97
143_L165_T0.9590.96
87_L91_D0.9570.96
96_L125_I0.9500.96
82_A95_I0.9390.96
162_R166_K0.9360.96
82_A121_A0.9330.96
149_W153_P0.9300.96
45_L81_L0.9270.96
109_V156_P0.9250.95
58_L102_K0.9190.95
102_K105_P0.9170.95
11_D16_R0.9120.95
38_A42_R0.9080.95
51_Y70_A0.9070.95
63_P156_P0.8940.95
10_T13_V0.8930.94
72_A117_R0.8780.94
41_R86_A0.8740.94
18_F60_G0.8690.94
49_L94_R0.8690.94
18_F117_R0.8580.93
89_K135_E0.8560.93
70_A102_K0.8500.93
52_L78_L0.8470.93
81_L84_N0.8400.92
134_A138_A0.8370.92
41_R92_L0.8330.92
24_A28_R0.8310.92
49_L53_A0.8290.92
96_L135_E0.8290.92
155_D158_G0.8240.92
103_L168_F0.8170.91
79_K83_R0.8100.91
52_L102_K0.8030.91
14_F17_S0.8010.91
156_P160_A0.7890.90
16_R55_E0.7870.90
21_L67_W0.7860.90
49_L98_A0.7850.90
21_L76_D0.7800.89
96_L131_L0.7790.89
73_H117_R0.7750.89
67_W117_R0.7720.89
3_Y15_R0.7650.89
153_P158_G0.7630.88
23_L27_A0.7620.88
23_L77_L0.7610.88
43_A47_A0.7480.87
91_D94_R0.7390.87
69_H76_D0.7360.87
71_V118_L0.7230.86
52_L71_V0.7210.85
58_L71_V0.7110.85
151_A155_D0.7090.84
18_F72_A0.7080.84
70_A74_G0.7060.84
20_A74_G0.7030.84
105_P110_Y0.7010.84
156_P159_L0.6980.84
28_R83_R0.6970.83
25_E79_K0.6960.83
6_G9_G0.6900.83
99_I122_V0.6890.83
99_I103_L0.6860.82
21_L72_A0.6820.82
102_K110_Y0.6770.82
39_E157_A0.6710.81
6_G13_V0.6680.81
60_G67_W0.6670.81
30_D85_P0.6590.80
45_L94_R0.6580.80
21_L117_R0.6570.80
21_L69_H0.6550.79
87_L92_L0.6540.79
72_A114_E0.6540.79
18_F76_D0.6530.79
166_K171_S0.6530.79
71_V121_A0.6530.79
17_S70_A0.6500.79
95_I99_I0.6480.79
13_V16_R0.6460.79
42_R45_L0.6390.78
52_L99_I0.6370.78
154_P159_L0.6360.77
100_A143_L0.6350.77
135_E138_A0.6300.77
84_N87_L0.6300.77
137_E141_A0.6270.76
43_A46_D0.6270.76
119_A172_L0.6250.76
108_H111_V0.6250.76
103_L110_Y0.6200.76
71_V80_Q0.6190.76
14_F59_R0.6170.75
19_S31_R0.6150.75
24_A120_R0.6130.75
113_G170_R0.6100.74
121_A139_W0.6090.74
148_A154_P0.6070.74
44_L81_L0.6070.74
151_A154_P0.6050.74
67_W72_A0.6030.74
28_R79_K0.6010.73
12_S90_A0.5990.73
83_R124_S0.5970.73
78_L121_A0.5970.73
48_A74_G0.5930.72
73_H76_D0.5930.72
28_R32_K0.5890.72
20_A48_A0.5820.71
49_L95_I0.5800.71
155_D160_A0.5800.71
48_A78_L0.5800.71
60_G73_H0.5800.71
27_A77_L0.5790.71
28_R124_S0.5750.70
114_E117_R0.5720.70
52_L98_A0.5710.70
44_L52_L0.5670.69
136_L140_L0.5650.69
46_D97_D0.5630.69
146_P153_P0.5620.68
74_G98_A0.5610.68
89_K138_A0.5600.68
169_L172_L0.5580.68
20_A24_A0.5580.68
53_A101_A0.5570.68
148_A152_A0.5570.68
90_A138_A0.5560.68
53_A94_R0.5550.67
17_S68_A0.5540.67
152_A156_P0.5530.67
82_A92_L0.5520.67
158_G162_R0.5510.67
146_P158_G0.5480.66
71_V105_P0.5460.66
5_I51_Y0.5440.66
92_L131_L0.5440.66
87_L121_A0.5430.66
104_A161_R0.5420.66
100_A142_R0.5400.65
29_R62_D0.5380.65
126_L136_L0.5370.65
160_A163_H0.5360.65
90_A93_A0.5350.65
11_D15_R0.5340.64
27_A84_N0.5290.64
17_S21_L0.5290.64
6_G11_D0.5260.63
9_G13_V0.5250.63
155_D165_T0.5230.63
17_S73_H0.5200.62
61_F65_K0.5190.62
31_R63_P0.5190.62
103_L136_L0.5180.62
149_W155_D0.5150.62
39_E43_A0.5140.62
159_L170_R0.5140.62
46_D50_A0.5110.61
93_A97_D0.5100.61
87_L95_I0.5090.61
45_L77_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qgrA 1 0.8851 40.3 0.931 Contact Map
1ddgA 1 0.6782 36.4 0.933 Contact Map
3qfsA 1 0.6897 33 0.935 Contact Map
1ibrB 1 0.8851 24.1 0.939 Contact Map
3qe2A 1 0.7011 23.7 0.939 Contact Map
2bpoA 1 0.7011 13.3 0.946 Contact Map
4uqfA 5 0.7931 12.4 0.946 Contact Map
4jbsA 1 0.8678 11.7 0.947 Contact Map
4kx7A 1 0.8793 11.3 0.947 Contact Map
2yd0A 1 0.9253 10.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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