GREMLIN Database
DUF2797 - Protein of unknown function (DUF2797)
PFAM: PF10977 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 231 (225)
Sequences: 3767 (2337)
Seq/√Len: 155.8
META: 0.795

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_E152_E4.8461.00
46_R49_L3.1291.00
5_S202_E3.0591.00
127_V153_L3.0331.00
91_Q94_T2.8901.00
31_Y35_F2.7941.00
71_P109_E2.6851.00
121_V124_K2.6141.00
7_E200_E2.5371.00
51_H56_T2.4871.00
21_T24_S2.4821.00
89_K109_E2.4611.00
19_R32_P2.4491.00
82_V149_E2.3631.00
183_V186_Y2.3541.00
38_P60_D2.3121.00
11_E230_E2.2731.00
108_A119_I2.2641.00
17_C33_C2.2451.00
145_D148_A2.2031.00
102_V141_V2.1671.00
114_Y118_L2.1511.00
3_E202_E2.1291.00
126_H156_L2.1101.00
29_F40_C2.0901.00
62_E66_K2.0601.00
122_A125_E2.0351.00
11_E20_K2.0251.00
195_L226_F1.9841.00
134_R138_K1.9771.00
86_I116_A1.9691.00
112_N115_L1.9621.00
103_Q178_E1.8921.00
6_L195_L1.8831.00
194_N226_F1.8771.00
9_T230_E1.8751.00
132_N135_K1.8411.00
78_N103_Q1.8291.00
62_E65_E1.8261.00
15_L228_G1.8031.00
196_D229_Y1.7951.00
111_P115_L1.7681.00
12_I24_S1.7431.00
73_I92_V1.7301.00
3_E204_T1.7141.00
23_K31_Y1.7071.00
73_I109_E1.6941.00
57_C64_E1.6201.00
30_C33_C1.6131.00
152_E156_L1.5801.00
43_C50_C1.5731.00
73_I89_K1.5651.00
185_E188_E1.5591.00
17_C30_C1.5361.00
81_G128_S1.5261.00
204_T216_D1.5061.00
203_G216_D1.4941.00
42_D49_L1.4781.00
39_Q60_D1.4741.00
221_I226_F1.4431.00
50_C68_C1.4391.00
57_C68_C1.4311.00
16_N39_Q1.4111.00
185_E206_L1.3781.00
73_I106_P1.3741.00
5_S200_E1.3711.00
16_N37_L1.3691.00
193_L201_I1.3601.00
29_F39_Q1.3491.00
18_G21_T1.3301.00
42_D45_M1.3301.00
13_N230_E1.3291.00
135_K140_E1.3271.00
4_I215_F1.3141.00
26_R34_F1.3111.00
64_E68_C1.2921.00
70_Q89_K1.2881.00
134_R191_K1.2751.00
43_C68_C1.2711.00
51_H54_L1.2681.00
135_K138_K1.2681.00
31_Y34_F1.2621.00
65_E69_L1.2621.00
194_N225_K1.2531.00
48_E124_K1.2451.00
71_P89_K1.2451.00
52_A69_L1.2311.00
32_P36_S1.2141.00
37_L41_D1.2071.00
13_N20_K1.1921.00
15_L227_E1.1821.00
69_L112_N1.1731.00
154_L171_L1.1611.00
126_H157_L1.1511.00
110_V116_A1.1311.00
226_F229_Y1.1291.00
144_V149_E1.1010.99
74_V110_V1.0840.99
74_V116_A1.0710.99
16_N29_F1.0670.99
57_C61_P1.0580.99
90_T93_P1.0540.99
52_A65_E1.0510.99
206_L218_G1.0410.99
151_D155_E1.0360.99
107_I150_R1.0360.99
150_R154_L1.0300.99
206_L216_D1.0270.99
151_D154_L1.0200.99
97_I179_I1.0160.99
67_H70_Q1.0160.99
52_A61_P1.0110.99
12_I21_T1.0020.99
149_E156_L0.9970.99
37_L40_C0.9940.99
61_P64_E0.9930.99
26_R227_E0.9880.99
105_L147_V0.9850.99
183_V207_G0.9770.99
41_D44_I0.9680.99
105_L146_L0.9550.99
110_V119_I0.9490.98
127_V149_E0.9300.98
42_D46_R0.9260.98
108_A170_Y0.9230.98
166_E170_Y0.9200.98
147_V150_R0.9180.98
79_S141_V0.9160.98
29_F37_L0.9140.98
70_Q90_T0.9090.98
108_A154_L0.9070.98
61_P65_E0.9060.98
63_W67_H0.8980.98
193_L203_G0.8920.98
41_D57_C0.8860.98
147_V176_V0.8760.97
105_L150_R0.8730.97
53_H114_Y0.8680.97
82_V144_V0.8670.97
41_D64_E0.8620.97
124_K130_K0.8620.97
166_E169_E0.8620.97
66_K70_Q0.8580.97
113_R117_G0.8360.97
147_V175_E0.8360.97
103_Q143_D0.8290.96
193_L198_T0.8280.96
77_A97_I0.8230.96
55_G65_E0.8210.96
71_P111_P0.8140.96
50_C57_C0.8120.96
146_L150_R0.8100.96
205_L213_L0.8100.96
25_F34_F0.8070.96
52_A64_E0.8050.96
78_N81_G0.7940.95
102_V209_K0.7910.95
195_L221_I0.7890.95
203_G215_F0.7880.95
86_I110_V0.7830.95
12_I18_G0.7830.95
168_I171_L0.7810.95
118_L167_A0.7740.95
184_L206_L0.7670.94
201_I221_I0.7660.94
15_L27_Q0.7580.94
155_E158_P0.7570.94
93_P97_I0.7560.94
216_D219_T0.7550.94
223_I231_V0.7520.94
106_P174_E0.7480.94
115_L118_L0.7420.93
140_E188_E0.7370.93
140_E186_Y0.7340.93
40_C43_C0.7330.93
61_P69_L0.7320.93
92_V104_A0.7300.93
42_D51_H0.7270.93
77_A102_V0.7260.93
14_C17_C0.7220.92
41_D68_C0.7150.92
19_R25_F0.7140.92
41_D51_H0.7100.92
168_I172_L0.7090.92
41_D63_W0.7090.92
107_I123_L0.7070.92
38_P61_P0.7070.92
74_V84_V0.7010.91
26_R40_C0.7010.91
148_A152_E0.7000.91
221_I225_K0.6980.91
78_N144_V0.6970.91
154_L168_I0.6950.91
88_R91_Q0.6950.91
122_A157_L0.6940.91
41_D52_A0.6890.91
192_S221_I0.6840.90
193_L226_F0.6830.90
196_D226_F0.6800.90
3_E7_E0.6790.90
38_P41_D0.6780.90
103_Q106_P0.6770.90
76_L146_L0.6760.90
21_T25_F0.6740.90
183_V187_P0.6700.89
61_P68_C0.6690.89
57_C69_L0.6660.89
131_T136_M0.6620.89
165_E169_E0.6590.89
93_P104_A0.6550.88
23_K35_F0.6540.88
122_A126_H0.6530.88
223_I226_F0.6490.88
206_L215_F0.6410.87
78_N127_V0.6410.87
193_L217_D0.6350.87
159_E168_I0.6340.87
22_K31_Y0.6330.87
52_A56_T0.6330.87
198_T219_T0.6280.86
203_G217_D0.6260.86
143_D178_E0.6230.86
14_C30_C0.6230.86
111_P166_E0.6210.85
167_A171_L0.6200.85
97_I136_M0.6170.85
48_E121_V0.6170.85
52_A57_C0.6160.85
226_F231_V0.6160.85
40_C52_A0.6160.85
206_L214_I0.6140.85
139_N186_Y0.6130.85
92_V97_I0.6120.85
107_I154_L0.6100.84
31_Y36_S0.6080.84
63_W68_C0.6060.84
193_L221_I0.6060.84
81_G102_V0.6050.84
43_C56_T0.6050.84
123_L153_L0.6030.84
19_R22_K0.6020.84
102_V142_E0.6000.84
116_A120_E0.5950.83
78_N141_V0.5950.83
167_A170_Y0.5930.83
189_K192_S0.5910.83
83_K95_R0.5900.82
183_V214_I0.5870.82
78_N82_V0.5870.82
47_P113_R0.5870.82
15_L26_R0.5860.82
1_G206_L0.5860.82
169_E172_L0.5850.82
198_T201_I0.5850.82
91_Q109_E0.5850.82
74_V119_I0.5820.82
184_L187_P0.5810.82
185_E218_G0.5800.81
24_S27_Q0.5790.81
201_I217_D0.5780.81
196_D199_P0.5740.81
29_F33_C0.5740.81
116_A121_V0.5680.80
201_I215_F0.5680.80
207_G220_V0.5680.80
25_F32_P0.5670.80
97_I208_I0.5670.80
13_N18_G0.5660.80
107_I153_L0.5650.80
78_N142_E0.5650.80
168_I174_E0.5640.80
23_K36_S0.5600.79
43_C57_C0.5590.79
56_T61_P0.5570.79
79_S102_V0.5560.79
174_E178_E0.5550.79
50_C56_T0.5540.78
154_L170_Y0.5520.78
134_R190_V0.5520.78
122_A158_P0.5510.78
117_G120_E0.5500.78
83_K99_Q0.5480.78
214_I218_G0.5460.77
75_Y83_K0.5450.77
191_K217_D0.5440.77
135_K142_E0.5430.77
75_Y99_Q0.5430.77
85_G99_Q0.5420.77
92_V177_T0.5400.77
76_L82_V0.5400.77
95_R99_Q0.5390.77
15_L29_F0.5390.77
75_Y85_G0.5390.77
102_V139_N0.5380.76
157_L167_A0.5370.76
75_Y95_R0.5370.76
135_K191_K0.5360.76
51_H64_E0.5360.76
85_G95_R0.5350.76
78_N102_V0.5340.76
184_L188_E0.5320.76
8_F12_I0.5320.76
68_C112_N0.5290.75
16_N26_R0.5280.75
45_M49_L0.5260.75
188_E191_K0.5260.75
22_K25_F0.5250.75
111_P170_Y0.5250.75
16_N34_F0.5230.74
196_D225_K0.5230.74
51_H57_C0.5220.74
32_P35_F0.5210.74
159_E169_E0.5210.74
53_H112_N0.5200.74
166_E174_E0.5190.74
89_K92_V0.5190.74
151_D168_I0.5180.74
186_Y189_K0.5170.74
138_K190_V0.5170.74
106_P177_T0.5160.73
91_Q210_G0.5160.73
177_T180_N0.5150.73
111_P167_A0.5150.73
128_S132_N0.5140.73
193_L219_T0.5140.73
139_N183_V0.5120.73
17_C21_T0.5100.73
26_R35_F0.5070.72
102_V128_S0.5070.72
9_T13_N0.5070.72
105_L172_L0.5060.72
23_K32_P0.5050.72
77_A141_V0.5040.72
117_G136_M0.5030.71
21_T33_C0.5030.71
23_K196_D0.5020.71
22_K36_S0.5010.71
227_E230_E0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jneA 1 0.2727 32.2 0.944 Contact Map
1ywlA 1 0.3463 19 0.95 Contact Map
4ui9S 1 0.29 15.3 0.952 Contact Map
2jrpA 1 0.316 10.8 0.955 Contact Map
1zg2A 1 0.3463 10.7 0.955 Contact Map
1v5xA 2 0.5931 8 0.958 Contact Map
4zr7A 1 0.5195 4.9 0.962 Contact Map
1nsjA 2 0.6017 4.9 0.962 Contact Map
2gmgA 1 0.1948 4.8 0.962 Contact Map
1v5nA 1 0.2294 4.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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