GREMLIN Database
DUF2802 - Protein of unknown function (DUF2802)
PFAM: PF10975 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (66)
Sequences: 2610 (1846)
Seq/√Len: 227.2
META: 0.86

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R10_E3.4371.00
45_S48_E3.1991.00
40_A49_L2.6331.00
37_I67_H2.4821.00
40_A64_L2.1231.00
20_L23_L2.1101.00
49_L60_A2.0991.00
62_L66_L2.0561.00
57_R61_E1.8501.00
37_I41_R1.7761.00
39_L53_C1.6891.00
46_V61_E1.5971.00
44_A48_E1.5791.00
7_A11_Q1.5541.00
19_R24_E1.5071.00
14_A18_E1.4811.00
55_L60_A1.4371.00
53_C60_A1.3981.00
17_E21_E1.2891.00
47_E57_R1.2251.00
12_R17_E1.2021.00
36_A55_L1.2021.00
19_R23_L1.1621.00
24_E27_D1.1021.00
18_E21_E1.0871.00
4_Q8_E1.0831.00
16_L20_L1.0541.00
8_E11_Q1.0521.00
32_S56_S1.0301.00
47_E51_E1.0251.00
40_A60_A1.0201.00
16_L23_L1.0171.00
15_R18_E0.9891.00
4_Q7_A0.9791.00
36_A53_C0.9761.00
42_Q52_S0.9751.00
3_G7_A0.9741.00
44_A50_A0.9561.00
44_A52_S0.9301.00
38_R42_Q0.9181.00
10_E14_A0.9161.00
14_A20_L0.8860.99
7_A10_E0.8850.99
58_A61_E0.8750.99
35_Q38_R0.8570.99
58_A65_R0.8400.99
50_A57_R0.8320.99
33_Y63_L0.8160.99
41_R67_H0.8140.99
59_E62_L0.7970.99
12_R15_R0.7820.98
46_V57_R0.7790.98
32_S65_R0.7760.98
8_E12_R0.7690.98
44_A60_A0.7430.98
34_S51_E0.7420.98
35_Q42_Q0.7420.98
35_Q58_A0.7420.98
8_E17_E0.7200.97
40_A63_L0.7160.97
59_E66_L0.7100.97
7_A12_R0.7010.97
49_L53_C0.7000.97
25_A28_P0.6990.97
33_Y65_R0.6990.97
49_L64_L0.6930.97
33_Y53_C0.6850.96
9_L13_L0.6770.96
31_R63_L0.6760.96
9_L16_L0.6750.96
17_E20_L0.6650.96
4_Q15_R0.6550.95
29_S41_R0.6530.95
32_S38_R0.6450.95
36_A60_A0.6420.95
31_R34_S0.6410.95
39_L61_E0.6380.95
48_E52_S0.6250.94
5_R12_R0.6100.93
28_P51_E0.6040.93
54_G63_L0.6030.93
29_S54_G0.5960.93
4_Q14_A0.5930.92
18_E26_R0.5830.92
35_Q52_S0.5820.92
14_A23_L0.5590.90
36_A40_A0.5580.90
22_E58_A0.5530.90
9_L20_L0.5530.90
15_R19_R0.5410.88
27_D31_R0.5360.88
3_G10_E0.5350.88
46_V64_L0.5310.88
50_A60_A0.5240.87
20_L25_A0.5240.87
4_Q12_R0.5230.87
38_R41_R0.5160.86
33_Y66_L0.5110.86
14_A21_E0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sfuA 1 0.6471 47.9 0.773 Contact Map
4wszA 2 0.6618 43.8 0.779 Contact Map
2jpcA 1 0.5588 42 0.782 Contact Map
3iuoA 4 0.6912 40.6 0.783 Contact Map
2x48A 1 0.7941 38.1 0.786 Contact Map
1tc3C 1 0.6765 37.8 0.787 Contact Map
3ugoA 1 0.1324 37.1 0.788 Contact Map
1ttyA 1 0.8529 36.3 0.789 Contact Map
3t72q 1 0.8676 36.3 0.789 Contact Map
3qp6A 2 1 34.3 0.791 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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