GREMLIN Database
DUF2799 - Protein of unknown function (DUF2799)
PFAM: PF10973 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (85)
Sequences: 3111 (2461)
Seq/√Len: 266.9
META: 0.847

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_R46_L3.8571.00
34_D37_A2.5471.00
49_Y58_L2.4361.00
22_H25_A2.4241.00
14_R18_R2.3231.00
19_L33_P2.2631.00
52_P80_A2.1011.00
9_D38_Y2.0771.00
35_L39_Q2.0591.00
74_E78_L1.9771.00
1_D4_A1.9481.00
54_N58_L1.7931.00
55_G77_F1.7671.00
58_L63_R1.6931.00
3_Y44_E1.6641.00
55_G80_A1.6601.00
7_Y11_A1.6481.00
10_G68_V1.6341.00
18_R21_E1.6271.00
70_P73_L1.6201.00
65_Y74_E1.5851.00
19_L35_L1.5431.00
39_Q43_E1.4341.00
18_R22_H1.3591.00
47_R72_D1.2951.00
82_Q85_R1.2881.00
57_R61_S1.2751.00
41_G45_G1.2711.00
37_A40_A1.2401.00
4_A7_Y1.2121.00
46_L68_V1.2061.00
7_Y48_E1.1961.00
54_N57_R1.1761.00
4_A8_E1.1691.00
23_R35_L1.1521.00
3_Y7_Y1.1311.00
5_I22_H1.1111.00
79_A83_A1.1011.00
80_A83_A1.0691.00
40_A44_E1.0601.00
3_Y41_G1.0491.00
10_G42_R1.0051.00
20_G23_R0.9911.00
78_L82_Q0.9891.00
16_A39_Q0.9731.00
21_E24_K0.9731.00
3_Y40_A0.9541.00
52_P56_F0.9431.00
81_Y85_R0.9401.00
80_A84_G0.9201.00
3_Y37_A0.9161.00
56_F60_R0.9061.00
65_Y77_F0.8951.00
8_E23_R0.8811.00
9_D22_H0.8771.00
74_E77_F0.8761.00
17_S20_G0.8611.00
47_R73_L0.8591.00
11_A48_E0.8541.00
22_H33_P0.8521.00
76_A79_A0.8421.00
36_A39_Q0.8320.99
44_E47_R0.8270.99
36_A40_A0.8220.99
71_A74_E0.8040.99
65_Y78_L0.8020.99
52_P55_G0.8000.99
59_G84_G0.7980.99
16_A42_R0.7910.99
51_T55_G0.7900.99
56_F84_G0.7780.99
16_A48_E0.7720.99
39_Q42_R0.7620.99
42_R68_V0.7300.99
49_Y68_V0.7300.99
73_L76_A0.7230.98
55_G59_G0.7220.98
10_G46_L0.6970.98
67_G77_F0.6960.98
62_G82_Q0.6870.98
5_I9_D0.6820.98
51_T54_N0.6770.98
64_S81_Y0.6700.98
19_L23_R0.6660.97
19_L22_H0.6620.97
50_C69_C0.6560.97
8_E11_A0.6550.97
28_K31_V0.6510.97
8_E35_L0.6500.97
67_G74_E0.6450.97
58_L77_F0.6330.97
56_F83_A0.6280.96
78_L81_Y0.6280.96
18_R38_Y0.6120.96
24_K27_A0.6090.96
79_A82_Q0.6080.96
29_H33_P0.6070.96
6_G41_G0.6070.96
7_Y44_E0.6060.96
10_G49_Y0.5980.95
16_A20_G0.5950.95
44_E48_E0.5950.95
8_E12_A0.5920.95
59_G65_Y0.5890.95
2_W6_G0.5890.95
14_R22_H0.5870.95
6_G10_G0.5860.95
49_Y54_N0.5770.94
55_G65_Y0.5710.94
38_Y77_F0.5700.94
58_L61_S0.5700.94
52_P76_A0.5510.93
4_A35_L0.5510.93
55_G84_G0.5450.92
8_E20_G0.5450.92
56_F80_A0.5370.92
39_Q44_E0.5350.92
38_Y73_L0.5330.91
59_G62_G0.5250.91
46_L65_Y0.5220.91
23_R27_A0.5200.90
15_P66_N0.5180.90
13_G46_L0.5180.90
24_K31_V0.5140.90
76_A80_A0.5050.89
20_G39_Q0.5020.89
45_G49_Y0.5020.89
7_Y10_G0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v22V 1 0.5 17.9 0.862 Contact Map
2jrmA 1 0.5233 17.6 0.863 Contact Map
3optA 1 0 1.9 0.913 Contact Map
4pmoA 1 0.8953 1.3 0.921 Contact Map
2ww2A 3 0.9535 1.3 0.922 Contact Map
3qweA 2 0.4651 1.2 0.922 Contact Map
3nrlA 2 0.2209 1.2 0.922 Contact Map
2hh8A 1 0.8023 1.2 0.923 Contact Map
2khfA 1 0.2093 1.2 0.923 Contact Map
4krdB 1 0.5116 1.2 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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