GREMLIN Database
CsiV - Peptidoglycan-binding protein, CsiV
PFAM: PF10972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 241 (221)
Sequences: 1821 (1577)
Seq/√Len: 106.1
META: 0.812

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_L236_V4.7201.00
30_E107_R4.4141.00
171_R174_H4.2731.00
97_A108_P4.2721.00
128_R162_D3.9761.00
91_L113_A3.9461.00
100_L108_P3.4571.00
23_Q115_R3.3621.00
28_V234_V3.3111.00
177_T234_V2.9211.00
224_L235_L2.7101.00
26_V165_I2.5421.00
167_L175_L2.4921.00
166_K176_D2.4181.00
27_I97_A2.3781.00
32_L107_R2.3601.00
25_E111_H2.3031.00
99_R102_R2.2951.00
217_R225_H2.2171.00
124_A166_K2.0981.00
177_T227_F2.0921.00
168_Y176_D2.0911.00
130_Q162_D1.9651.00
172_Y218_R1.9291.00
219_M227_F1.9171.00
132_G160_E1.8761.00
222_G240_P1.8081.00
178_D212_R1.7731.00
221_S240_P1.7131.00
178_D214_K1.7011.00
96_I235_L1.6851.00
118_G169_L1.6631.00
100_L106_Y1.6481.00
83_F86_L1.6361.00
10_L13_S1.6101.00
211_Y231_L1.6051.00
170_S174_H1.6001.00
14_S17_A1.5761.00
169_L221_S1.5631.00
17_A20_R1.5561.00
126_P166_K1.5541.00
217_R220_R1.5451.00
21_W82_G1.5331.00
86_L113_A1.5171.00
83_F117_P1.4761.00
131_A160_E1.4711.00
24_V238_I1.4571.00
25_E113_A1.4251.00
27_I93_L1.4041.00
29_F233_G1.3801.00
103_S106_Y1.3761.00
213_L232_F1.3501.00
132_G135_L1.3280.99
183_E231_L1.3220.99
42_W231_L1.3210.99
220_R225_H1.3100.99
91_L94_N1.2880.99
217_R221_S1.2860.99
199_N202_A1.2770.99
24_V167_L1.2630.99
15_A19_E1.2480.99
5_L8_L1.2460.99
15_A18_A1.2430.99
4_L7_L1.2350.99
4_L11_L1.2340.99
30_E160_E1.2170.99
172_Y221_S1.2170.99
167_L238_I1.2090.99
181_L232_F1.2060.99
48_L51_P1.2010.99
86_L111_H1.1910.99
98_R102_R1.1820.99
227_F236_V1.1700.99
219_M225_H1.1650.99
22_Y169_L1.1540.98
9_L13_S1.1430.98
182_R210_S1.1420.98
196_L199_N1.1400.98
196_L200_S1.1180.98
51_P54_A1.1150.98
23_Q92_Q1.1120.98
128_R180_W1.1090.98
23_Q239_T1.1080.98
202_A205_P1.0940.98
197_P200_S1.0930.98
91_L111_H1.0930.98
180_W210_S1.0930.98
21_W117_P1.0770.98
173_L218_R1.0710.97
172_Y217_R1.0580.97
120_D123_Q1.0430.97
171_R218_R1.0350.97
73_L76_C1.0270.97
25_E91_L1.0250.97
21_W180_W1.0210.97
97_A111_H1.0180.97
51_P58_L1.0100.96
220_R223_E1.0040.96
96_I99_R0.9950.96
23_Q113_A0.9920.96
32_L103_S0.9920.96
173_L221_S0.9910.96
23_Q111_H0.9910.96
42_W229_H0.9870.96
118_G125_P0.9800.96
177_T213_L0.9770.96
198_A204_P0.9720.95
51_P57_L0.9710.95
224_L237_Q0.9640.95
21_W115_R0.9590.95
29_F226_Y0.9590.95
229_H232_F0.9570.95
197_P201_E0.9540.95
95_D99_R0.9460.95
55_I58_L0.9450.95
104_G115_R0.9430.95
56_D59_S0.9370.94
77_D80_E0.9320.94
33_D37_A0.9300.94
6_L9_L0.9300.94
163_G179_L0.9280.94
227_F234_V0.9270.94
169_L219_M0.9200.94
176_D216_S0.9180.94
106_Y213_L0.9170.94
135_L139_F0.9160.94
53_N56_D0.9150.94
50_D55_I0.9130.94
46_L50_D0.9050.93
221_S225_H0.8950.93
93_L97_A0.8920.93
165_I175_L0.8900.93
25_E93_L0.8900.93
96_I224_L0.8780.92
6_L10_L0.8760.92
30_E109_L0.8750.92
218_R225_H0.8740.92
22_Y238_I0.8730.92
121_R168_Y0.8660.92
174_H216_S0.8650.92
25_E92_Q0.8600.92
164_T178_D0.8520.91
162_D182_R0.8510.91
198_A202_A0.8470.91
109_L161_L0.8400.91
120_D222_G0.8370.90
29_F106_Y0.8350.90
6_L12_A0.8320.90
226_Y233_G0.8220.90
101_R108_P0.8210.90
129_I161_L0.8140.89
126_P164_T0.8130.89
9_L12_A0.8120.89
74_P78_A0.8090.89
69_L73_L0.8070.89
194_D197_P0.8060.89
7_L10_L0.8050.89
24_V116_Q0.8030.89
91_L112_T0.8010.88
96_I100_L0.8000.88
174_H218_R0.7970.88
69_L72_G0.7950.88
108_P227_F0.7940.88
31_R216_S0.7930.88
24_V118_G0.7920.88
68_A75_E0.7910.88
204_P207_D0.7850.87
82_G117_P0.7790.87
215_Q227_F0.7760.87
93_L113_A0.7740.87
67_T71_E0.7740.87
92_Q237_Q0.7710.86
5_L11_L0.7680.86
200_S204_P0.7670.86
196_L203_E0.7660.86
5_L9_L0.7630.86
164_T179_L0.7610.86
130_Q159_W0.7590.86
88_E98_R0.7580.86
195_D198_A0.7550.85
66_I72_G0.7540.85
62_L65_D0.7530.85
217_R223_E0.7530.85
26_V112_T0.7500.85
31_R106_Y0.7490.85
198_A201_E0.7490.85
40_E230_P0.7440.84
200_S203_E0.7430.84
27_I62_L0.7400.84
199_N204_P0.7400.84
228_D233_G0.7370.84
195_D201_E0.7330.84
123_Q234_V0.7330.84
121_R124_A0.7310.83
225_H229_H0.7280.83
14_S19_E0.7260.83
193_A196_L0.7260.83
206_S209_T0.7230.83
193_A199_N0.7230.83
13_S17_A0.7190.82
161_L181_L0.7180.82
13_S18_A0.7180.82
49_P54_A0.7120.82
131_A135_L0.7110.82
68_A71_E0.7060.81
162_D180_W0.7050.81
108_P112_T0.7030.81
118_G173_L0.7010.81
223_E230_P0.6990.81
87_P90_E0.6980.80
96_I232_F0.6970.80
4_L22_Y0.6950.80
42_W220_R0.6930.80
190_P194_D0.6810.79
172_Y220_R0.6800.79
31_R35_A0.6800.79
50_D57_L0.6770.78
222_G238_I0.6730.78
93_L174_H0.6670.77
203_E206_S0.6670.77
193_A203_E0.6580.76
220_R240_P0.6550.76
12_A20_R0.6540.76
66_I69_L0.6520.76
124_A127_I0.6520.76
76_C79_A0.6480.75
175_L234_V0.6480.75
36_S39_S0.6450.75
7_L13_S0.6390.74
219_M223_E0.6390.74
170_S173_L0.6390.74
16_A19_E0.6380.74
121_R170_S0.6350.74
169_L238_I0.6340.74
69_L76_C0.6320.74
21_W83_F0.6270.73
68_A73_L0.6270.73
65_D72_G0.6270.73
63_A69_L0.6250.73
201_E205_P0.6250.73
103_S113_A0.6220.72
15_A20_R0.6210.72
30_E231_L0.6200.72
190_P193_A0.6200.72
22_Y235_L0.6190.72
164_T216_S0.6140.71
200_S205_P0.6130.71
85_L110_L0.6090.71
211_Y216_S0.6080.71
195_D205_P0.6080.71
219_M238_I0.6070.71
28_V183_E0.6050.70
169_L172_Y0.5990.70
64_P234_V0.5970.69
7_L12_A0.5970.69
69_L75_E0.5960.69
81_D127_I0.5940.69
66_I71_E0.5920.69
74_P79_A0.5890.68
199_N203_E0.5890.68
201_E204_P0.5890.68
215_Q232_F0.5880.68
21_W162_D0.5880.68
65_D74_P0.5880.68
171_R219_M0.5820.67
54_A59_S0.5800.67
168_Y219_M0.5800.67
26_V236_V0.5790.67
8_L13_S0.5770.67
97_A112_T0.5770.67
194_D205_P0.5750.66
103_S116_Q0.5750.66
92_Q111_H0.5740.66
27_I235_L0.5740.66
4_L12_A0.5730.66
119_L226_Y0.5700.66
97_A101_R0.5700.66
165_I237_Q0.5680.65
169_L216_S0.5660.65
14_S18_A0.5640.65
180_W212_R0.5640.65
194_D201_E0.5630.65
96_I116_Q0.5620.65
38_G167_L0.5600.64
197_P204_P0.5600.64
218_R224_L0.5600.64
19_E61_Y0.5580.64
225_H235_L0.5580.64
70_E78_A0.5540.64
51_P55_I0.5510.63
72_G75_E0.5490.63
192_A209_T0.5490.63
93_L106_Y0.5480.63
168_Y216_S0.5470.63
169_L173_L0.5430.62
68_A80_E0.5420.62
68_A72_G0.5410.62
112_T232_F0.5400.62
202_A207_D0.5400.62
198_A207_D0.5360.61
22_Y118_G0.5340.61
67_T70_E0.5340.61
108_P173_L0.5330.61
195_D199_N0.5300.60
113_A239_T0.5300.60
192_A198_A0.5290.60
43_P178_D0.5290.60
70_E75_E0.5280.60
169_L218_R0.5270.60
74_P80_E0.5240.59
8_L12_A0.5240.59
7_L11_L0.5230.59
171_R227_F0.5220.59
129_I238_I0.5210.59
127_I227_F0.5180.58
25_E161_L0.5180.58
129_I163_G0.5150.58
160_E181_L0.5130.58
167_L173_L0.5120.58
98_R101_R0.5110.57
28_V179_L0.5110.57
225_H230_P0.5100.57
193_A201_E0.5090.57
30_E183_E0.5070.57
15_A189_D0.5060.57
227_F232_F0.5060.57
199_N205_P0.5050.57
161_L175_L0.5040.56
118_G221_S0.5040.56
94_N101_R0.5040.56
159_W162_D0.5020.56
94_N98_R0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n5bB 3 0.0788 66 0.925 Contact Map
2vdaB 1 0.0747 2.1 0.965 Contact Map
2d1gA 2 0.1992 2 0.966 Contact Map
4um9B 2 0 1.6 0.968 Contact Map
2mmjA 1 0.0456 1.6 0.968 Contact Map
4g3bA 3 0.0954 1.5 0.968 Contact Map
4dgfA 1 0.2988 1.4 0.969 Contact Map
4whiA 1 0.361 1.3 0.969 Contact Map
1sg5A 1 0.3444 1.3 0.969 Contact Map
1th8B 1 0.2863 1.2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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