GREMLIN Database
DUF2769 - Protein of unknown function (DUF2769)
PFAM: PF10967 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (56)
Sequences: 1955 (1264)
Seq/√Len: 168.9
META: 0.939

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_C31_C3.7791.00
35_E58_T2.9951.00
35_E55_Y2.9771.00
41_P54_G2.2571.00
24_A49_Y2.0731.00
4_P20_G1.7311.00
12_E15_K1.7061.00
45_V49_Y1.6031.00
46_Y56_Y1.5731.00
19_E22_F1.5471.00
21_L25_R1.5211.00
12_E16_K1.5041.00
39_I42_T1.4901.00
37_G55_Y1.4731.00
5_K39_I1.4391.00
46_Y51_L1.4321.00
6_C40_C1.3441.00
2_I42_T1.3361.00
42_T47_K1.3231.00
46_Y54_G1.3181.00
46_Y53_G1.3081.00
38_C43_C1.2191.00
8_S37_G1.1231.00
55_Y58_T1.1111.00
14_A22_F1.0791.00
9_Y19_E1.0580.99
21_L24_A1.0190.99
44_P48_E1.0000.99
2_I39_I0.9970.99
47_K52_K0.9720.99
21_L51_L0.9710.99
9_Y21_L0.9650.99
3_C23_C0.9510.99
53_G56_Y0.9290.99
19_E28_S0.9140.98
46_Y49_Y0.8700.98
47_K54_G0.8350.97
8_S14_A0.8170.97
9_Y20_G0.8000.96
1_C6_C0.8000.96
8_S18_P0.7930.96
9_Y15_K0.7910.96
10_N24_A0.7910.96
26_G30_K0.7880.96
10_N14_A0.7850.96
30_K34_E0.7800.96
25_R49_Y0.7790.96
40_C43_C0.7770.96
10_N21_L0.7460.95
25_R52_K0.7440.95
2_I5_K0.7140.94
2_I44_P0.7110.93
9_Y22_F0.6990.93
7_P37_G0.6960.93
24_A51_L0.6810.92
21_L49_Y0.6730.91
8_S33_K0.6690.91
3_C26_G0.6560.90
12_E18_P0.6360.89
5_K27_K0.6350.89
22_F34_E0.6190.88
10_N46_Y0.6080.87
26_G40_C0.6050.86
8_S22_F0.6040.86
32_I35_E0.5990.86
13_C17_K0.5950.85
27_K53_G0.5910.85
5_K41_P0.5890.85
4_P15_K0.5760.84
19_E31_C0.5720.83
27_K32_I0.5590.82
14_A32_I0.5480.80
21_L45_V0.5400.80
28_S32_I0.5370.79
30_K33_K0.5330.79
14_A17_K0.5240.77
25_R44_P0.5230.77
15_K30_K0.5210.77
20_G23_C0.5200.77
10_N58_T0.5140.76
5_K48_E0.5090.75
36_K50_G0.5070.75
6_C26_G0.5020.74
15_K18_P0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jjdA 1 0.7241 11.8 0.84 Contact Map
4ay9B 1 0.4483 6.4 0.858 Contact Map
3fl7A 2 0.8448 1.7 0.894 Contact Map
2p26A 1 0.5172 1.5 0.897 Contact Map
4iu6A 1 0 1.4 0.899 Contact Map
3rq4A 1 0.2586 1.4 0.899 Contact Map
3kv4A 1 0.6724 1.1 0.906 Contact Map
4l58A 1 0.6379 1 0.908 Contact Map
1t2yA 1 0.1552 1 0.908 Contact Map
2ri7A 1 0.6552 0.9 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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