GREMLIN Database
DUF2758 - Protein of unknown function (DUF2758)
PFAM: PF10957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (58)
Sequences: 586 (450)
Seq/√Len: 59.1
META: 0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L29_I3.3461.00
35_K57_I2.4761.00
7_F56_I2.4351.00
5_K16_E2.2781.00
17_E21_E2.0941.00
36_Y53_S2.0931.00
30_E59_K1.8881.00
23_L29_I1.7080.99
24_E29_I1.6430.99
42_I45_G1.6160.99
21_E27_D1.5760.99
13_K16_E1.5750.99
22_F58_Y1.5490.98
44_F47_E1.5230.98
6_I13_K1.4280.97
47_E52_F1.4110.97
41_S44_F1.3880.97
18_A21_E1.3260.96
26_L31_I1.3100.95
6_I37_Q1.2450.94
48_Q51_C1.2410.94
28_E59_K1.2390.94
21_E25_E1.2130.93
43_E46_E1.2090.93
34_I54_A1.2060.93
24_E28_E1.2030.93
9_E18_A1.1660.92
8_D48_Q1.1630.92
19_I56_I1.1530.91
40_I51_C1.0980.89
27_D59_K1.0510.87
4_V22_F1.0340.86
9_E15_L1.0190.85
4_V19_I0.9950.84
17_E30_E0.9770.83
8_D14_D0.9380.80
11_H14_D0.9330.80
8_D12_E0.8700.75
7_F19_I0.8670.74
11_H50_Y0.8440.72
39_A50_Y0.7960.68
29_I36_Y0.7810.66
16_E58_Y0.7650.65
12_E48_Q0.7530.64
6_I56_I0.7500.63
12_E53_S0.7420.62
2_M58_Y0.7390.62
14_D52_F0.7310.61
12_E50_Y0.7270.61
17_E56_I0.7120.59
4_V23_L0.7080.59
32_I57_I0.7060.59
41_S53_S0.6870.57
54_A58_Y0.6770.55
15_L52_F0.6740.55
8_D49_I0.6670.54
7_F36_Y0.6650.54
11_H39_A0.6520.53
31_I44_F0.6440.52
35_K38_V0.6390.51
14_D22_F0.6350.51
27_D32_I0.6350.51
19_I32_I0.6300.50
42_I46_E0.6270.50
40_I43_E0.6260.50
3_K23_L0.6250.50
52_F55_M0.6200.49
30_E33_D0.6170.49
19_I31_I0.6140.48
12_E15_L0.6130.48
6_I59_K0.6030.47
26_L30_E0.5730.44
12_E49_I0.5660.43
19_I54_A0.5640.43
7_F44_F0.5620.43
14_D51_C0.5550.42
29_I32_I0.5530.42
21_E46_E0.5500.41
10_E17_E0.5490.41
37_Q55_M0.5340.40
40_I50_Y0.5320.39
44_F56_I0.5310.39
19_I26_L0.5290.39
2_M45_G0.5090.37
25_E56_I0.5060.37
48_Q52_F0.5040.36
12_E52_F0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iayA 1 0.5833 7.6 0.872 Contact Map
3j80C 1 0.9333 7.5 0.872 Contact Map
3bgyA 1 0.75 6.9 0.874 Contact Map
4bpeE 1 0.9333 6.2 0.877 Contact Map
4ujpD 1 0.95 6.2 0.877 Contact Map
4kzyC 1 0.9333 6.1 0.878 Contact Map
3j60C 1 0.9333 6 0.878 Contact Map
5a2qC 1 0.9333 5.8 0.879 Contact Map
3zeyP 1 0.9333 5.2 0.881 Contact Map
3j7aG 1 0.9333 4.2 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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