GREMLIN Database
DUF2757 - Protein of unknown function (DUF2757)
PFAM: PF10955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (71)
Sequences: 553 (386)
Seq/√Len: 45.8
META: 0.486

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_I53_V3.8071.00
29_F51_V3.4871.00
59_Q63_E3.3901.00
56_E59_Q3.0581.00
44_D48_D2.8191.00
67_E70_E2.5711.00
4_H16_E2.5241.00
29_F41_I2.1111.00
13_K16_E1.8950.99
33_T40_I1.7540.98
62_L68_L1.7480.98
25_E30_H1.6660.98
68_L71_L1.6620.98
23_D26_Q1.5960.97
33_T36_E1.5480.96
3_I49_I1.5430.96
5_Y28_G1.4550.95
2_A48_D1.3450.92
44_D52_K1.2630.89
7_C10_C1.2540.89
65_N68_L1.1810.86
61_A65_N1.1460.84
31_F38_Q1.0980.82
4_H13_K1.0850.81
6_V50_T1.0580.79
16_E71_L1.0430.78
19_Q35_E1.0370.78
28_G32_L1.0240.77
3_I22_V1.0110.76
9_H54_I0.9970.75
28_G36_E0.9870.74
5_Y36_E0.9730.73
53_V59_Q0.9630.72
8_R15_G0.9420.71
9_H15_G0.9340.70
24_E37_R0.9300.70
5_Y27_L0.9260.69
2_A16_E0.9210.69
17_I29_F0.9210.69
24_E57_D0.9180.69
9_H43_Y0.9180.69
60_E64_R0.9150.68
43_Y49_I0.9010.67
18_E21_S0.9010.67
28_G37_R0.8490.62
3_I9_H0.8370.61
2_A54_I0.8340.61
14_I31_F0.8300.61
5_Y29_F0.8240.60
54_I59_Q0.8110.59
8_R57_D0.8050.58
27_L32_L0.7920.57
15_G36_E0.7910.57
4_H50_T0.7820.56
27_L37_R0.7570.54
33_T39_D0.7500.53
55_C58_C0.7420.52
27_L43_Y0.7410.52
41_I49_I0.7300.51
37_R67_E0.7250.51
2_A53_V0.7150.50
40_I50_T0.7010.48
11_G53_V0.6840.47
26_Q35_E0.6810.46
40_I70_E0.6760.46
28_G65_N0.6570.44
14_I26_Q0.6510.43
33_T71_L0.6490.43
62_L69_H0.6460.43
2_A51_V0.6460.43
62_L65_N0.6460.43
6_V52_K0.6370.42
38_Q56_E0.6340.42
6_V13_K0.6280.41
53_V61_A0.6240.41
18_E42_S0.6230.41
44_D50_T0.6200.40
19_Q22_V0.6130.40
43_Y62_L0.6040.39
15_G66_P0.6010.39
19_Q26_Q0.5950.38
5_Y32_L0.5860.37
21_S46_N0.5840.37
1_M7_C0.5770.36
17_I37_R0.5750.36
11_G63_E0.5690.36
25_E38_Q0.5670.35
44_D49_I0.5640.35
14_I42_S0.5590.35
34_P42_S0.5570.35
9_H48_D0.5560.34
8_R54_I0.5540.34
10_C58_C0.5510.34
10_C55_C0.5510.34
5_Y10_C0.5490.34
24_E51_V0.5480.34
26_Q67_E0.5390.33
13_K18_E0.5330.32
4_H26_Q0.5270.32
59_Q64_R0.5260.32
3_I34_P0.5210.31
23_D53_V0.5160.31
9_H16_E0.5150.31
38_Q42_S0.5120.31
45_S60_E0.5030.30
57_D64_R0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq0A 2 0.7632 71 0.852 Contact Map
1i7fA 2 0.1053 70.8 0.852 Contact Map
1vzyA 3 0.7763 62.4 0.86 Contact Map
2xigA 4 0.7237 47.5 0.872 Contact Map
3eyyA 2 0.6447 45.3 0.873 Contact Map
2fe3A 2 0.7368 42.1 0.876 Contact Map
3mwmA 2 0.6974 39.4 0.878 Contact Map
2o03A 2 0.6711 36.6 0.88 Contact Map
1vziA 2 0.8684 36.3 0.88 Contact Map
1y07A 3 0.8684 33.7 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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