GREMLIN Database
DUF2628 - Protein of unknown function (DUF2628)
PFAM: PF10947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (81)
Sequences: 5236 (3900)
Seq/√Len: 433.4
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_L46_L4.1261.00
40_R89_R2.9571.00
36_W85_A2.7391.00
26_N86_N2.5431.00
45_A92_T2.1911.00
37_L81_V2.1221.00
84_E87_S1.9771.00
30_F82_G1.9741.00
37_L49_Y1.9411.00
25_F82_G1.7491.00
42_L45_A1.5901.00
42_L92_T1.5621.00
26_N29_A1.5481.00
46_L49_Y1.5391.00
46_L50_L1.5341.00
37_L46_L1.5111.00
25_F30_F1.5091.00
16_V19_G1.4481.00
27_W31_L1.4371.00
67_A71_L1.4151.00
74_G78_A1.4051.00
45_A88_L1.3761.00
84_E88_L1.3611.00
79_L83_L1.3321.00
34_P46_L1.3091.00
58_L62_A1.3011.00
58_L61_A1.2901.00
44_L48_G1.2381.00
86_N89_R1.2171.00
13_F16_V1.1791.00
82_G85_A1.1691.00
35_L39_Y1.1601.00
26_N89_R1.1361.00
53_S57_G1.1351.00
37_L88_L1.1071.00
37_L85_A1.0961.00
15_F19_G1.0731.00
54_V58_L1.0671.00
87_S91_W1.0671.00
80_L84_E1.0531.00
49_Y81_V1.0391.00
33_G78_A1.0161.00
42_L89_R0.9831.00
90_R94_E0.9731.00
47_L51_V0.9731.00
59_A62_A0.9451.00
49_Y53_S0.9251.00
37_L45_A0.9241.00
34_P49_Y0.9201.00
52_L77_L0.9161.00
52_L56_L0.9081.00
14_V18_D0.9061.00
51_V54_V0.9031.00
33_G81_V0.8831.00
29_A85_A0.8651.00
28_W39_Y0.8521.00
25_F83_L0.8511.00
66_G69_A0.8411.00
81_V88_L0.8351.00
28_W36_W0.8241.00
12_R15_F0.8221.00
60_L70_I0.8201.00
16_V90_R0.8101.00
78_A81_V0.7891.00
42_L81_V0.7871.00
10_A13_F0.7801.00
75_L79_L0.7731.00
29_A36_W0.7671.00
88_L91_W0.7651.00
78_A82_G0.7631.00
28_W40_R0.7541.00
57_G60_L0.7491.00
10_A14_V0.7421.00
65_A69_A0.7331.00
29_A81_V0.7161.00
26_N42_L0.7071.00
28_W33_G0.7061.00
65_A68_A0.7041.00
57_G74_G0.7041.00
14_V17_R0.7001.00
28_W31_L0.6941.00
87_S90_R0.6921.00
64_G69_A0.6891.00
19_G36_W0.6771.00
48_G52_L0.6691.00
73_V78_A0.6661.00
66_G70_I0.6631.00
42_L88_L0.6550.99
17_R86_N0.6530.99
59_A63_L0.6510.99
62_A66_G0.6490.99
28_W32_F0.6460.99
10_A27_W0.6350.99
68_A72_L0.6200.99
57_G61_A0.6180.99
30_F79_L0.6180.99
67_A70_I0.6090.99
14_V89_R0.6090.99
44_L51_V0.6060.99
64_G67_A0.6060.99
26_N85_A0.6060.99
61_A94_E0.6020.99
26_N40_R0.5950.99
89_R92_T0.5950.99
61_A70_I0.5920.99
60_L65_A0.5820.99
45_A91_W0.5790.99
37_L42_L0.5770.99
65_A70_I0.5700.99
13_F90_R0.5640.98
32_F35_L0.5630.98
68_A71_L0.5600.98
51_V55_A0.5600.98
41_R44_L0.5320.98
29_A82_G0.5320.98
66_G72_L0.5300.98
36_W86_N0.5290.98
48_G51_V0.5230.98
45_A48_G0.5100.97
44_L47_L0.5100.97
11_E14_V0.5010.97
55_A58_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.9789 53.4 0.841 Contact Map
4wd8A 3 0.5895 13.9 0.882 Contact Map
4rdqA 5 0.8842 7.3 0.896 Contact Map
1rh1A 1 0.9895 3.7 0.909 Contact Map
2eo2A 1 0.2526 3.6 0.91 Contact Map
4u9nA 2 0.7158 2.6 0.916 Contact Map
4k0jA 3 0.9474 1.9 0.922 Contact Map
3j9tb 1 0 1.9 0.923 Contact Map
4dx5A 3 1 1.7 0.924 Contact Map
3w9iA 3 1 1.7 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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