GREMLIN Database
DUF2630 - Protein of unknown function (DUF2630)
PFAM: PF10944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (79)
Sequences: 7926 (4528)
Seq/√Len: 509.5
META: 0.953

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E36_R2.9481.00
57_R62_Q2.5751.00
42_V72_A2.3111.00
38_R41_E2.2271.00
10_E14_A2.0811.00
47_C69_V2.0041.00
73_D77_G1.9541.00
71_P74_T1.9441.00
18_E22_R1.7991.00
53_Q67_A1.7691.00
29_S32_D1.7291.00
35_A39_E1.7021.00
62_Q66_E1.6721.00
8_R11_E1.6661.00
20_R41_E1.5951.00
6_L55_R1.5481.00
3_E7_A1.5181.00
57_R67_A1.5061.00
57_R66_E1.4731.00
39_E43_E1.4211.00
74_T79_L1.4141.00
7_A11_E1.3481.00
74_T77_G1.3411.00
14_A18_E1.3341.00
53_Q57_R1.2671.00
6_L10_E1.2641.00
38_R42_V1.2501.00
31_D35_A1.2461.00
34_R38_R1.2271.00
69_V72_A1.2171.00
53_Q70_R1.1781.00
8_R43_E1.1751.00
56_A59_E1.1511.00
2_D58_R1.1471.00
20_R37_L1.1441.00
4_D43_E1.1151.00
35_A38_R1.1121.00
57_R60_A1.0851.00
23_E34_R1.0841.00
14_A17_H1.0721.00
17_H21_E1.0571.00
4_D7_A1.0451.00
28_L32_D1.0321.00
23_E29_S1.0271.00
8_R47_C1.0251.00
36_R39_E1.0091.00
3_E8_R1.0011.00
7_A10_E0.9771.00
23_E28_L0.9571.00
21_E24_A0.9451.00
46_Q72_A0.9441.00
55_R59_E0.9361.00
63_D66_E0.9161.00
21_E25_A0.9061.00
15_E18_E0.8881.00
69_V79_L0.8701.00
23_E26_G0.8531.00
43_E46_Q0.8471.00
18_E21_E0.8451.00
10_E13_V0.8381.00
16_E51_L0.8351.00
15_E40_L0.8321.00
20_R34_R0.8271.00
12_L40_L0.8191.00
1_D4_D0.8041.00
39_E42_V0.8041.00
17_H48_W0.7941.00
22_R32_D0.7851.00
70_R74_T0.7811.00
7_A14_A0.7531.00
32_D35_A0.7371.00
20_R23_E0.7321.00
43_E47_C0.7251.00
22_R26_G0.7161.00
22_R27_G0.7141.00
28_L34_R0.7111.00
11_E18_E0.7011.00
8_R12_L0.7001.00
56_A60_A0.6881.00
6_L43_E0.6751.00
37_L40_L0.6731.00
39_E72_A0.6721.00
46_Q69_V0.6701.00
11_E15_E0.6621.00
12_L15_E0.6581.00
30_D35_A0.6581.00
6_L13_V0.6451.00
51_L54_R0.6451.00
13_V17_H0.6371.00
13_V40_L0.6361.00
30_D34_R0.6301.00
52_R79_L0.6281.00
23_E27_G0.6271.00
68_Q71_P0.6271.00
42_V76_E0.6251.00
17_H20_R0.6181.00
36_R40_L0.6161.00
73_D79_L0.6030.99
42_V75_V0.5930.99
23_E30_D0.5840.99
3_E6_L0.5810.99
8_R69_V0.5610.99
3_E11_E0.5550.99
11_E14_A0.5520.99
47_C51_L0.5500.99
44_L47_C0.5450.99
13_V16_E0.5420.99
67_A78_Y0.5400.99
16_E54_R0.5370.99
5_I50_L0.5330.99
59_E65_D0.5290.99
20_R24_A0.5260.99
44_L51_L0.5260.99
10_E52_R0.5220.99
13_V48_W0.5180.98
42_V74_T0.5060.98
25_A28_L0.5040.98
6_L47_C0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tp9Y 1 0.675 6 0.911 Contact Map
4rb62 1 0.675 5.3 0.913 Contact Map
4pxjA 2 0.5875 4.9 0.914 Contact Map
3j3wX 1 0.65 3.9 0.919 Contact Map
3wo8A 2 0.7375 3.7 0.92 Contact Map
2zjrV 1 0.7 3.2 0.922 Contact Map
1r73A 1 0.7125 3.1 0.923 Contact Map
1vq8V 1 0.6625 3 0.923 Contact Map
3j21W 1 0.775 2.9 0.924 Contact Map
2r2yA 1 0.1875 2.7 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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