GREMLIN Database
DUF2619 - Protein of unknown function (DUF2619)
PFAM: PF10942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (69)
Sequences: 642 (440)
Seq/√Len: 53.0
META: 0.662

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_F27_I2.6781.00
11_A27_I2.6571.00
61_W68_L2.6321.00
5_G9_I2.5921.00
4_S8_E2.5661.00
37_L41_T2.3581.00
13_L16_L2.1891.00
64_L68_L1.9361.00
32_A43_T1.8760.99
14_L27_I1.8550.99
26_K29_A1.7800.99
26_K30_L1.7570.99
3_L7_I1.7050.99
9_I13_L1.6960.99
6_S10_T1.6490.98
2_L5_G1.5210.97
17_K53_K1.5080.97
8_E31_L1.4890.97
39_L43_T1.4730.97
21_V55_S1.4030.96
25_L39_L1.3650.95
44_T48_V1.3560.95
20_R23_K1.3490.95
26_K42_V1.3430.95
42_V45_I1.3270.94
25_L58_K1.2850.93
11_A15_M1.2780.93
10_T15_M1.2030.91
19_N32_A1.1970.90
22_E53_K1.1430.88
32_A59_L0.9730.79
25_L50_L0.9710.78
2_L9_I0.9670.78
30_L62_I0.9580.77
39_L49_G0.9500.77
6_S29_A0.9490.77
4_S31_L0.9360.76
59_L63_L0.9230.75
5_G34_V0.9190.74
11_A59_L0.9140.74
33_L40_I0.9080.74
23_K32_A0.9000.73
39_L42_V0.8970.73
23_K42_V0.8850.72
29_A42_V0.8600.69
10_T30_L0.8530.69
25_L63_L0.8410.68
14_L18_F0.8260.66
26_K32_A0.8130.65
39_L69_I0.8020.64
14_L30_L0.7940.63
63_L67_A0.7710.61
2_L13_L0.7660.60
23_K26_K0.7600.60
2_L6_S0.7540.59
15_M42_V0.7510.59
46_G58_K0.7450.58
34_V66_V0.7310.57
62_I66_V0.7230.56
24_A35_G0.7150.55
62_I65_G0.7120.55
9_I41_T0.7110.55
4_S35_G0.6960.53
9_I58_K0.6920.53
8_E39_L0.6760.51
58_K62_I0.6750.51
8_E35_G0.6690.50
4_S32_A0.6660.50
24_A31_L0.6630.50
42_V61_W0.6540.49
22_E49_G0.6520.49
56_L64_L0.6510.48
66_V69_I0.6470.48
4_S34_V0.6400.47
58_K61_W0.6390.47
4_S11_A0.6350.47
5_G48_V0.6160.45
51_A58_K0.6150.45
7_I34_V0.6020.43
6_S67_A0.5970.43
21_V50_L0.5940.42
40_I63_L0.5920.42
9_I24_A0.5900.42
13_L37_L0.5880.42
5_G12_A0.5820.41
17_K49_G0.5800.41
35_G42_V0.5760.41
47_L62_I0.5650.40
7_I10_T0.5640.39
12_A57_S0.5610.39
3_L6_S0.5570.39
21_V42_V0.5560.39
29_A68_L0.5460.38
34_V48_V0.5440.37
25_L46_G0.5420.37
47_L67_A0.5320.36
65_G69_I0.5320.36
14_L69_I0.5220.35
40_I56_L0.5220.35
32_A39_L0.5190.35
30_L54_L0.5070.34
15_M18_F0.5020.33
7_I23_K0.5020.33
27_I68_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 1 5.8 0.901 Contact Map
2i68A 2 0.7681 4.1 0.907 Contact Map
2m67A 1 0.7536 2.6 0.916 Contact Map
4zw9A 1 0.9565 2.2 0.919 Contact Map
4dx5A 3 0.913 2 0.921 Contact Map
2nwlA 3 0.971 1.8 0.923 Contact Map
4ev6A 3 0.913 1.8 0.923 Contact Map
2h3oA 1 0.4638 1.7 0.924 Contact Map
1wazA 1 0.5072 1.6 0.926 Contact Map
4mt1A 3 0.913 1.6 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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