GREMLIN Database
DUF2631 - Protein of unknown function (DUF2631)
PFAM: PF10939 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (63)
Sequences: 676 (343)
Seq/√Len: 43.2
META: 0.661

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_L46_A4.3611.00
18_V26_S4.2081.00
55_H58_D3.6771.00
45_L65_A3.0271.00
47_M61_L2.3591.00
52_H57_E1.9150.99
39_F43_F1.9070.99
38_W41_A1.7980.98
51_N57_E1.7840.98
60_W64_F1.7320.98
50_G57_E1.6170.97
36_A40_S1.5660.96
22_E30_P1.3950.92
48_L62_I1.3830.92
44_L65_A1.3560.91
28_E33_W1.3340.91
18_V23_W1.2800.89
5_V8_H1.2700.88
38_W42_L1.2590.88
54_G59_I1.1970.85
59_I63_G1.1220.81
50_G54_G1.0640.77
35_I39_F1.0290.75
51_N54_G1.0200.74
43_F47_M1.0140.74
33_W40_S1.0120.74
3_T6_E0.9280.67
27_G30_P0.9220.67
60_W63_G0.9200.66
58_D62_I0.9070.65
28_E32_T0.9050.65
3_T10_G0.8910.64
18_V21_A0.8850.63
16_A32_T0.8790.63
48_L58_D0.8760.63
9_T23_W0.8610.61
52_H55_H0.8600.61
26_S29_N0.8380.59
51_N58_D0.8360.59
15_P21_A0.8320.58
22_E32_T0.8310.58
41_A46_A0.8170.57
34_R41_A0.8080.56
9_T22_E0.8010.56
56_V59_I0.7970.55
50_G58_D0.7800.54
4_E14_D0.7770.53
35_I38_W0.7690.53
29_N33_W0.7610.52
3_T16_A0.7590.52
52_H58_D0.7580.52
34_R38_W0.7550.51
51_N61_L0.7440.50
54_G57_E0.7390.50
23_W31_R0.7380.50
5_V9_T0.7240.48
44_L64_F0.7160.48
42_L63_G0.7050.46
41_A44_L0.6960.46
56_V60_W0.6940.45
3_T9_T0.6930.45
2_S36_A0.6750.44
50_G56_V0.6720.43
55_H59_I0.6590.42
45_L52_H0.6550.42
36_A39_F0.6500.41
15_P22_E0.6440.41
6_E23_W0.6310.40
7_R14_D0.6200.39
18_V29_N0.6150.38
51_N56_V0.6120.38
53_V57_E0.6120.38
39_F42_L0.5950.36
43_F46_A0.5930.36
32_T36_A0.5900.36
23_W37_G0.5850.35
4_E31_R0.5830.35
15_P20_S0.5760.35
7_R10_G0.5720.34
21_A26_S0.5680.34
15_P39_F0.5630.34
13_V21_A0.5510.33
13_V17_D0.5490.32
7_R22_E0.5380.31
20_S26_S0.5330.31
5_V10_G0.5330.31
49_I53_V0.5290.31
8_H28_E0.5290.31
18_V37_G0.5230.30
15_P19_P0.5200.30
15_P29_N0.5190.30
34_R37_G0.5140.30
17_D66_A0.5040.29
10_G13_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bs2C 2 0.9242 4.7 0.921 Contact Map
1z1nX 1 0.1818 2.9 0.929 Contact Map
1fftB 1 0.2424 2.8 0.929 Contact Map
3v2yA 1 0.9545 2.5 0.931 Contact Map
3vpgA 3 0.8939 2.4 0.932 Contact Map
2cvcA 1 0.197 2.2 0.934 Contact Map
1hfoA 3 0.4545 2.1 0.934 Contact Map
3kanA 3 0.5 2.1 0.934 Contact Map
1mwwA 3 0.5152 2.1 0.935 Contact Map
2e84A 1 0.1818 2 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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