GREMLIN Database
DUF2617 - Protein of unknown function DUF2617
PFAM: PF10936 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (136)
Sequences: 1375 (932)
Seq/√Len: 79.9
META: 0.793

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_E26_E4.0681.00
68_P71_L3.8851.00
40_A140_L3.5161.00
42_L131_L3.3971.00
75_P78_V3.3671.00
23_E27_I3.3591.00
34_E39_E3.2971.00
44_I119_H3.2521.00
24_L27_I2.7181.00
123_G126_G2.4551.00
76_D80_C2.3691.00
43_R50_V2.3521.00
63_V68_P2.2601.00
128_L147_T2.1751.00
116_G121_F2.1391.00
64_V68_P1.9171.00
48_G148_F1.8981.00
75_P80_C1.8121.00
66_C71_L1.7931.00
48_G129_T1.7691.00
86_Q158_Q1.7351.00
44_I121_F1.6921.00
67_A70_P1.6281.00
48_G146_H1.6181.00
51_V142_V1.5581.00
67_A71_L1.5520.99
63_V66_C1.5450.99
37_G56_G1.5050.99
76_D79_E1.4600.99
54_R59_T1.4550.99
131_L144_T1.4540.99
127_A149_P1.4410.99
94_L105_E1.4380.99
39_E54_R1.4270.99
35_R38_Y1.4000.99
63_V67_A1.3990.99
126_G129_T1.3970.99
40_A51_V1.3850.99
32_R41_T1.3620.99
75_P81_R1.3390.98
129_T146_H1.2720.98
64_V69_G1.2450.98
134_E141_L1.2380.97
147_T154_I1.2340.97
34_E37_G1.1730.96
78_V81_R1.1670.96
40_A133_V1.1530.96
86_Q160_L1.1390.96
52_T59_T1.1290.96
119_H122_P1.1280.96
139_S160_L1.1260.96
92_E105_E1.1160.95
30_S41_T1.1140.95
103_H128_L1.0930.95
106_L144_T1.0890.95
32_R39_E1.0860.95
29_A117_L1.0660.94
93_T117_L1.0390.93
28_L46_G1.0260.93
58_G61_T1.0190.92
63_V71_L1.0160.92
98_L109_D0.9920.91
113_R132_D0.9920.91
58_G62_E0.9730.91
42_L133_V0.9480.89
46_G129_T0.9460.89
76_D81_R0.9370.89
101_A104_Q0.9310.89
133_V157_T0.9230.88
98_L101_A0.9180.88
132_D157_T0.9090.87
92_E102_V0.9020.87
63_V70_P0.8940.87
142_V145_F0.8890.86
92_E134_E0.8870.86
46_G144_T0.8830.86
27_I43_R0.8820.86
144_T148_F0.8670.85
136_R139_S0.8640.85
46_G148_F0.8640.85
37_G42_L0.8620.84
96_P121_F0.8620.84
50_V63_V0.8500.84
44_I48_G0.8500.84
55_A58_G0.8500.84
67_A150_D0.8470.83
105_E109_D0.8360.83
141_L158_Q0.8310.82
95_S98_L0.8260.82
84_R131_L0.8240.82
135_A139_S0.8210.81
46_G51_V0.7760.78
92_E156_K0.7660.77
31_R117_L0.7520.75
144_T159_S0.7520.75
46_G66_C0.7470.75
43_R69_G0.7470.75
84_R107_L0.7460.75
105_E108_A0.7440.75
107_L120_R0.7400.74
25_F65_A0.7360.74
129_T144_T0.7350.74
72_R82_G0.7170.72
38_Y140_L0.7150.72
66_C129_T0.7090.71
127_A130_A0.7080.71
43_R52_T0.7060.71
94_L98_L0.7020.70
103_H127_A0.7020.70
23_E28_L0.6990.70
48_G121_F0.6980.70
65_A159_S0.6970.70
49_H62_E0.6960.70
24_L92_E0.6960.70
42_L140_L0.6910.69
104_Q108_A0.6910.69
58_G72_R0.6890.69
28_L122_P0.6850.68
104_Q155_V0.6830.68
138_R148_F0.6830.68
45_T129_T0.6830.68
130_A157_T0.6800.68
53_W142_V0.6780.68
66_C69_G0.6730.67
30_S56_G0.6730.67
106_L116_G0.6680.67
28_L94_L0.6660.66
51_V137_P0.6660.66
24_L140_L0.6620.66
64_V70_P0.6570.65
33_V40_A0.6500.64
74_L159_S0.6500.64
27_I128_L0.6490.64
113_R136_R0.6490.64
156_K160_L0.6480.64
73_R158_Q0.6480.64
40_A143_Q0.6470.64
91_V96_P0.6460.64
90_Q98_L0.6450.64
92_E155_V0.6440.64
122_P138_R0.6440.64
129_T148_F0.6380.63
41_T104_Q0.6360.63
119_H142_V0.6350.63
64_V85_Y0.6330.62
98_L102_V0.6290.62
96_P141_L0.6260.62
65_A122_P0.6250.61
27_I30_S0.6230.61
34_E112_K0.6220.61
49_H146_H0.6200.61
138_R155_V0.6170.60
96_P100_W0.6150.60
95_S102_V0.6120.60
77_R80_C0.6010.58
33_V95_S0.5980.58
59_T62_E0.5940.58
86_Q104_Q0.5930.57
134_E158_Q0.5920.57
121_F148_F0.5920.57
28_L40_A0.5900.57
122_P157_T0.5880.57
65_A70_P0.5860.57
75_P84_R0.5770.55
148_F155_V0.5760.55
64_V87_F0.5760.55
123_G127_A0.5750.55
25_F50_V0.5740.55
43_R67_A0.5710.55
53_W87_F0.5690.54
111_A117_L0.5660.54
48_G66_C0.5520.52
46_G121_F0.5510.52
88_S98_L0.5490.52
107_L111_A0.5480.52
118_L121_F0.5450.51
117_L121_F0.5440.51
127_A145_F0.5420.51
143_Q154_I0.5410.51
43_R102_V0.5400.51
32_R120_R0.5390.50
132_D141_L0.5350.50
47_A148_F0.5350.50
88_S140_L0.5330.50
38_Y121_F0.5330.50
40_A59_T0.5320.50
42_L81_R0.5310.49
37_G55_A0.5290.49
150_D153_A0.5280.49
64_V71_L0.5260.49
45_T145_F0.5260.49
102_V105_E0.5220.48
36_G157_T0.5200.48
102_V107_L0.5200.48
135_A140_L0.5190.48
130_A154_I0.5160.47
29_A159_S0.5130.47
57_G78_V0.5110.47
89_F157_T0.5070.46
88_S158_Q0.5030.46
62_E146_H0.5010.46
29_A140_L0.5010.46
59_T83_V0.5000.45
41_T58_G0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jzaA 2 0.5714 11.1 0.935 Contact Map
3nwoA 1 0.4224 5.3 0.944 Contact Map
1ehyA 1 0.4161 5.2 0.944 Contact Map
2pujA 4 0.4348 4.8 0.945 Contact Map
2xmzA 1 0.4037 4.7 0.945 Contact Map
4batA 2 0.4161 4.4 0.946 Contact Map
2wueA 4 0.3851 4.3 0.946 Contact Map
3wmrA 1 0.3975 4.2 0.947 Contact Map
1mtzA 1 0.3975 3.9 0.947 Contact Map
3w06A 1 0.3975 3.8 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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