GREMLIN Database
DUF2637 - Protein of unknown function (DUF2637)
PFAM: PF10935 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 160 (144)
Sequences: 1611 (1156)
Seq/√Len: 96.3
META: 0.673

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_P100_P3.0921.00
135_L145_R2.9461.00
136_A139_A2.8511.00
19_Y37_W2.8011.00
13_A38_L2.4231.00
78_S82_N2.3971.00
18_S44_D2.3691.00
96_P99_A2.3391.00
44_D78_S2.3071.00
6_G49_V2.2291.00
129_A133_W1.9451.00
133_W140_T1.8381.00
46_G50_A1.7761.00
143_A146_R1.7691.00
46_G74_L1.7141.00
13_A42_I1.7111.00
21_A31_V1.6871.00
71_A74_L1.6441.00
22_L81_A1.6421.00
32_P35_L1.6381.00
95_P100_P1.6151.00
138_L142_A1.6131.00
139_A142_A1.5881.00
128_L133_W1.5771.00
80_A83_V1.5661.00
80_A84_A1.5621.00
96_P104_E1.5421.00
104_E108_A1.5331.00
16_A35_L1.5121.00
22_L26_A1.5101.00
26_A39_F1.5031.00
96_P103_F1.4761.00
16_A25_L1.4631.00
112_R115_L1.4581.00
99_A103_F1.4171.00
92_A100_P1.3970.99
23_R27_R1.3820.99
116_R119_G1.3560.99
25_L30_G1.3310.99
93_A96_P1.3170.99
15_F75_A1.3010.99
141_L144_W1.3000.99
137_P143_A1.2930.99
140_T143_A1.2780.99
23_R37_W1.2770.99
95_P99_A1.2740.99
89_A92_A1.2670.99
92_A99_A1.2650.99
100_P104_E1.2620.99
17_L22_L1.2620.99
11_A19_Y1.1990.98
19_Y40_P1.1980.98
68_R72_W1.1920.98
137_P140_T1.1890.98
6_G52_L1.1780.98
100_P103_F1.1760.98
44_D103_F1.1730.98
14_A42_I1.1710.98
100_P108_A1.1670.98
92_A104_E1.1450.98
127_R130_A1.1290.98
140_T144_W1.1190.97
79_V83_V1.1190.97
15_F47_I1.1150.97
136_A140_T1.0990.97
126_P132_R1.0890.97
116_R120_L1.0810.97
92_A95_P1.0770.97
114_A118_A1.0700.97
17_L35_L1.0700.97
95_P102_L1.0560.96
23_R43_V1.0550.96
15_F21_A1.0490.96
118_A122_A1.0400.96
57_L62_R1.0390.96
98_A102_L1.0370.96
92_A108_A1.0220.96
97_V104_E1.0200.95
128_L143_A1.0190.95
106_L111_R0.9970.95
16_A38_L0.9960.95
131_A134_L0.9860.95
129_A132_R0.9860.95
11_A15_F0.9780.94
66_R77_A0.9770.94
10_L17_L0.9750.94
27_R33_G0.9700.94
21_A85_H0.9630.94
15_F48_V0.9620.94
62_R65_R0.9610.94
17_L39_F0.9600.94
12_A16_A0.9480.93
67_A74_L0.9470.93
91_V95_P0.9410.93
135_L139_A0.9400.93
134_L138_L0.9350.93
39_F54_A0.9170.92
128_L131_A0.9110.92
94_A99_A0.9070.92
62_R112_R0.9050.92
131_A144_W0.9030.92
119_G123_A0.8980.91
41_L49_V0.8910.91
140_T145_R0.8660.90
93_A98_A0.8510.89
92_A96_P0.8490.89
130_A138_L0.8460.89
23_R36_A0.8460.89
74_L78_S0.8450.89
9_L41_L0.8420.88
136_A141_L0.8400.88
91_V104_E0.8320.88
65_R69_L0.8300.88
139_A143_A0.8270.88
89_A96_P0.8260.87
88_A100_P0.8200.87
130_A133_W0.8190.87
42_I57_L0.8130.87
138_L141_L0.8130.87
16_A34_A0.8060.86
138_L143_A0.7960.85
47_I78_S0.7950.85
100_P107_L0.7910.85
104_E107_L0.7870.85
89_A104_E0.7720.84
120_L123_A0.7680.83
36_A43_V0.7680.83
31_V35_L0.7630.83
89_A93_A0.7610.83
17_L23_R0.7580.83
127_R139_A0.7580.83
68_R71_A0.7570.82
142_A146_R0.7530.82
31_V42_I0.7510.82
99_A105_L0.7460.82
68_R74_L0.7460.82
127_R136_A0.7450.81
138_L146_R0.7370.81
118_A123_A0.7340.80
92_A103_F0.7280.80
126_P129_A0.7280.80
76_A141_L0.7240.80
91_V100_P0.7230.79
97_V100_P0.7230.79
22_L78_S0.7200.79
40_P44_D0.7100.78
90_V93_A0.7070.78
21_A79_V0.6990.77
27_R36_A0.6920.76
79_V82_N0.6910.76
99_A102_L0.6900.76
22_L44_D0.6830.76
44_D55_L0.6820.75
43_V107_L0.6800.75
48_V52_L0.6740.75
107_L110_V0.6730.74
20_A35_L0.6720.74
87_W92_A0.6710.74
93_A97_V0.6710.74
76_A80_A0.6700.74
135_L140_T0.6620.73
7_V12_A0.6580.73
14_A49_V0.6540.72
71_A75_A0.6530.72
95_P105_L0.6510.72
139_A146_R0.6480.72
68_R111_R0.6460.71
22_L31_V0.6390.71
69_L73_A0.6330.70
6_G56_A0.6320.70
112_R116_R0.6300.70
17_L37_W0.6260.69
119_G125_A0.6230.69
64_A67_A0.6200.68
130_A134_L0.6190.68
101_V106_L0.6140.68
9_L20_A0.6080.67
136_A143_A0.6080.67
61_G76_A0.6050.66
12_A122_A0.6040.66
16_A56_A0.5980.66
96_P108_A0.5980.66
50_A74_L0.5970.65
128_L140_T0.5950.65
18_S103_F0.5940.65
21_A25_L0.5870.64
51_A71_A0.5840.64
46_G85_H0.5820.63
14_A46_G0.5810.63
43_V47_I0.5770.63
72_W78_S0.5660.61
41_L46_G0.5640.61
22_L85_H0.5610.61
135_L141_L0.5560.60
141_L145_R0.5520.59
139_A145_R0.5450.58
134_L141_L0.5430.58
90_V96_P0.5410.58
3_A53_L0.5400.58
10_L45_G0.5360.57
103_F107_L0.5340.57
103_F108_A0.5330.57
21_A81_A0.5330.57
117_R120_L0.5270.56
99_A104_E0.5220.55
3_A45_G0.5190.55
135_L144_W0.5150.54
137_P145_R0.5140.54
9_L62_R0.5090.53
113_A117_R0.5090.53
136_A145_R0.5080.53
32_P46_G0.5060.53
19_Y79_V0.5050.53
57_L109_A0.5030.53
41_L89_A0.5020.52
20_A56_A0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.3312 3.2 0.929 Contact Map
4ev6A 3 0.3438 1.8 0.938 Contact Map
3giaA 1 0.6875 1.1 0.945 Contact Map
3ne5A 3 0.375 1 0.946 Contact Map
3ixzA 1 0.4375 0.9 0.947 Contact Map
3wu2J 1 0.1625 0.8 0.95 Contact Map
2zxeA 1 0.4188 0.7 0.951 Contact Map
1m56D 1 0.1125 0.7 0.952 Contact Map
1qleD 1 0.1125 0.7 0.953 Contact Map
1wazA 1 0.2875 0.6 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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