GREMLIN Database
DUF2783 - Protein of unknown function (DUF2783)
PFAM: PF10932 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (58)
Sequences: 4256 (2070)
Seq/√Len: 271.8
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_D12_D2.8791.00
26_D30_A2.8381.00
16_A51_R2.8221.00
20_A32_L2.7961.00
25_S28_Q2.1671.00
2_N6_N2.0791.00
20_A54_L1.9041.00
21_H29_S1.8811.00
13_F50_L1.8811.00
13_F41_A1.7681.00
15_E19_D1.7031.00
47_L51_R1.6781.00
43_H49_V1.6031.00
24_L32_L1.5801.00
31_A35_R1.5041.00
19_D22_R1.4721.00
52_E56_A1.4491.00
21_H33_N1.3631.00
30_A33_N1.3621.00
16_A47_L1.3311.00
43_H53_A1.3181.00
40_L53_A1.3011.00
33_N37_V1.3001.00
39_L56_A1.2441.00
29_S33_N1.2121.00
8_A46_D1.2011.00
40_L44_I1.1551.00
24_L58_R1.1251.00
1_L53_A1.1001.00
13_F17_L1.0531.00
8_A47_L1.0231.00
44_I49_V1.0171.00
7_L13_F1.0151.00
28_Q31_A0.9651.00
41_A50_L0.9341.00
1_L43_H0.8481.00
9_D47_L0.8330.99
16_A55_A0.8140.99
32_L35_R0.7750.99
39_L57_A0.7400.99
3_T52_E0.7370.99
24_L28_Q0.7260.99
32_L58_R0.7170.98
12_D47_L0.7160.98
39_L53_A0.7060.98
15_E22_R0.6970.98
3_T56_A0.6910.98
21_H32_L0.6880.98
36_L53_A0.6720.98
48_A52_E0.6630.97
2_N5_P0.6560.97
49_V52_E0.6470.97
23_G58_R0.6460.97
49_V53_A0.6380.97
31_A34_A0.6350.97
37_V54_L0.6280.97
17_L31_A0.6280.97
21_H24_L0.6220.96
7_L47_L0.6080.96
20_A24_L0.6060.96
5_P10_P0.6060.96
50_L54_L0.6050.96
20_A57_A0.5950.95
16_A19_D0.5940.95
12_D51_R0.5890.95
7_L10_P0.5830.95
13_F54_L0.5790.95
13_F47_L0.5720.94
10_P18_I0.5670.94
48_A55_A0.5630.94
48_A51_R0.5500.93
34_A37_V0.5480.93
43_H52_E0.5370.92
9_D48_A0.5260.91
6_N50_L0.5250.91
7_L19_D0.5230.91
39_L58_R0.5200.91
11_D29_S0.5160.91
21_H37_V0.5130.90
10_P41_A0.5100.90
53_A56_A0.5080.90
30_A37_V0.5050.90
35_R58_R0.5040.89
7_L41_A0.5030.89
29_S37_V0.5020.89
8_A35_R0.5000.89
33_N36_L0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1khdA 2 0.9322 7.1 0.878 Contact Map
2xs1A 1 0.5932 6.1 0.881 Contact Map
4xgcC 1 0.8814 6.1 0.882 Contact Map
1c7cA 1 1 5.9 0.883 Contact Map
3pvsA 4 1 5.8 0.883 Contact Map
2r80A 2 1 5.5 0.884 Contact Map
4fhnB 1 0.9492 5.3 0.885 Contact Map
3bomB 1 1 5 0.887 Contact Map
1lhsA 1 1 5 0.887 Contact Map
2w72C 2 1 4.7 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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