GREMLIN Database
DUF2735 - Protein of unknown function (DUF2735)
PFAM: PF10931 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (51)
Sequences: 1846 (1192)
Seq/√Len: 166.9
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_E49_Q5.3291.00
10_G13_A4.0471.00
46_A50_E2.4691.00
10_G14_A1.9431.00
39_G45_E1.9171.00
36_A39_G1.6611.00
6_Q9_A1.6571.00
32_R35_E1.6101.00
9_A13_A1.6021.00
28_L31_P1.5661.00
25_A28_L1.5621.00
11_G14_A1.5291.00
46_A49_Q1.4381.00
20_G23_K1.4131.00
37_A45_E1.3181.00
19_R22_A1.1721.00
40_G45_E1.1421.00
44_H47_A1.1311.00
10_G15_L1.0691.00
33_V36_A1.0400.99
26_A29_A1.0160.99
27_D30_A1.0110.99
25_A30_A1.0090.99
22_A29_A0.9710.99
34_N39_G0.9570.99
9_A15_L0.9560.99
28_L33_V0.9210.99
3_K13_A0.8590.98
22_A27_D0.8390.97
43_Y47_A0.8290.97
1_S35_E0.8220.97
25_A29_A0.7870.96
29_A32_R0.7790.96
6_Q31_P0.7780.96
14_A17_G0.7750.96
37_A46_A0.7700.95
32_R37_A0.7680.95
27_D32_R0.7600.95
30_A35_E0.7550.95
38_C41_S0.7530.95
41_S48_I0.7470.95
41_S45_E0.7470.95
2_A7_F0.7430.95
23_K27_D0.7330.94
4_I7_F0.7310.94
20_G24_A0.7040.93
18_R22_A0.7010.93
47_A50_E0.6970.92
16_G19_R0.6810.92
1_S25_A0.6720.91
1_S6_Q0.6670.91
16_G40_G0.6620.90
36_A41_S0.6570.90
24_A28_L0.6550.90
1_S31_P0.6460.89
35_E38_C0.6420.89
23_K33_V0.6280.88
1_S4_I0.6260.88
22_A25_A0.6230.88
42_W51_A0.6170.87
28_L32_R0.6070.86
27_D34_N0.5810.84
26_A32_R0.5790.84
22_A26_A0.5710.83
40_G46_A0.5700.83
6_Q49_Q0.5620.82
1_S28_L0.5580.81
3_K27_D0.5380.79
34_N38_C0.5380.79
21_E27_D0.5310.78
19_R23_K0.5250.77
17_G26_A0.5190.76
32_R45_E0.5080.75
8_P51_A0.5010.74
12_R48_I0.5010.74
38_C45_E0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kyjA 1 0.2308 3.5 0.879 Contact Map
2gmfA 1 0.3846 3.3 0.88 Contact Map
4eyzA 1 0.3846 3.2 0.881 Contact Map
2wsdA 1 0.5192 2.7 0.885 Contact Map
2r7eA 1 0.6923 2.6 0.887 Contact Map
3abgA 1 0.5192 2.6 0.887 Contact Map
1xioA 2 0 2.4 0.888 Contact Map
3oaeA 5 0.3654 2.1 0.893 Contact Map
3gyrA 4 1 2 0.893 Contact Map
2r5iA 5 0.3654 2 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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