GREMLIN Database
DUF2811 - Protein of unknown function (DUF2811)
PFAM: PF10929 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (57)
Sequences: 675 (269)
Seq/√Len: 35.6
META: 0.846

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_M27_Y2.5151.00
14_M29_L2.4881.00
51_L55_N2.1790.99
28_R50_R2.0350.99
40_Q57_F1.8080.97
25_D33_A1.7920.97
4_A30_I1.6250.94
34_L41_N1.6200.94
33_A38_L1.6060.94
13_A49_T1.5590.93
6_I30_I1.5110.92
7_P33_A1.4990.91
2_L45_D1.4690.90
17_F47_A1.4160.89
24_W28_R1.3930.88
23_N48_V1.3840.87
12_E16_D1.3210.85
17_F27_Y1.2730.83
5_E43_C1.2300.80
10_L56_L1.2260.80
22_P25_D1.2100.79
6_I9_E1.2090.79
1_S28_R1.2000.79
39_F55_N1.1860.78
8_E56_L1.1810.78
47_A52_Y1.1380.75
34_L37_F1.1050.73
8_E15_K1.0840.71
46_R57_F1.0840.71
26_Q33_A1.0710.70
19_E30_I1.0400.68
39_F51_L1.0320.67
42_G48_V1.0150.66
2_L6_I0.9890.64
45_D48_V0.9610.62
15_K41_N0.9580.62
21_H49_T0.9580.62
6_I21_H0.9560.61
53_L56_L0.9440.60
29_L39_F0.9090.57
3_E8_E0.9050.57
41_N44_E0.9010.57
28_R36_G0.8960.56
36_G55_N0.8910.56
27_Y35_A0.8780.55
35_A48_V0.8770.55
33_A46_R0.8740.54
13_A28_R0.8160.49
13_A32_A0.8140.49
24_W32_A0.8130.49
8_E12_E0.8120.49
25_D31_Q0.8110.49
33_A42_G0.7980.48
19_E27_Y0.7940.48
21_H42_G0.7930.47
50_R55_N0.7800.46
51_L54_D0.7620.45
11_H32_A0.7590.45
31_Q36_G0.7370.43
16_D19_E0.7300.42
3_E30_I0.7120.41
49_T53_L0.7080.40
2_L9_E0.7050.40
54_D57_F0.6970.39
24_W35_A0.6960.39
20_S34_L0.6870.39
29_L56_L0.6360.34
28_R32_A0.6310.34
26_Q42_G0.6170.33
46_R49_T0.6060.32
49_T52_Y0.6040.32
44_E47_A0.5930.31
2_L56_L0.5820.30
15_K55_N0.5800.30
36_G46_R0.5610.29
35_A39_F0.5550.28
7_P10_L0.5390.27
5_E41_N0.5260.26
45_D55_N0.5230.26
50_R54_D0.5230.26
1_S27_Y0.5210.26
19_E36_G0.5200.26
21_H44_E0.5200.26
11_H51_L0.5180.26
16_D50_R0.5130.26
19_E55_N0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p94A 2 0.7193 47.4 0.854 Contact Map
2kelA 2 0.7368 40.8 0.86 Contact Map
2k9iA 2 0.7895 39.8 0.86 Contact Map
2mdvA 2 0.6491 36.8 0.863 Contact Map
2cpgA 2 0.7368 34.4 0.865 Contact Map
2k5jA 2 0.8596 27.7 0.871 Contact Map
4me7E 2 0.9825 22.3 0.877 Contact Map
4aybC 1 0.807 21.7 0.878 Contact Map
4ps6A 1 0.4386 20.3 0.879 Contact Map
4f0jA 2 0.3509 18.3 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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