GREMLIN Database
DUF2781 - Protein of unknown function (DUF2781)
PFAM: PF10914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 145 (138)
Sequences: 1362 (932)
Seq/√Len: 79.3
META: 0.59

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_Q25_P4.2301.00
40_Y127_A2.7601.00
91_Y138_L2.7591.00
26_Y29_W2.7541.00
93_G97_T2.5931.00
107_L121_L2.4551.00
58_A104_G2.3731.00
94_M97_T2.3681.00
12_L72_L2.2961.00
20_L24_L2.1551.00
76_Y81_R2.0661.00
96_A132_L2.0161.00
70_F74_A1.9481.00
76_Y83_W1.8791.00
78_F88_A1.8391.00
70_F88_A1.8381.00
20_L64_A1.7811.00
31_A35_D1.7761.00
88_A142_M1.7611.00
61_W65_L1.7511.00
3_V134_I1.7181.00
86_L89_L1.6971.00
70_F87_P1.6641.00
59_T98_N1.6191.00
107_L125_L1.5961.00
92_A139_L1.5851.00
133_L137_L1.5590.99
90_I93_G1.5470.99
96_A139_L1.5320.99
6_V10_I1.5060.99
5_L79_L1.5010.99
111_H117_A1.5010.99
62_I94_M1.4970.99
117_A120_N1.4880.99
9_L75_I1.4870.99
4_F138_L1.4830.99
5_L75_I1.4790.99
140_L143_W1.4630.99
138_L142_M1.3970.99
122_L126_A1.3940.99
67_Q71_Y1.3880.99
94_M100_L1.3470.98
11_N15_T1.3350.98
55_W110_P1.3180.98
7_F11_N1.3070.98
4_F137_L1.2900.98
31_A34_V1.2590.98
58_A101_I1.2380.97
138_L141_R1.1740.96
5_L9_L1.1670.96
4_F141_R1.1640.96
40_Y44_F1.1590.96
86_L143_W1.1450.96
12_L68_G1.1370.96
129_L132_L1.1340.96
77_A84_I1.1340.96
46_D49_L1.1330.96
17_L24_L1.1320.96
105_E110_P1.1300.96
98_N101_I1.1250.95
104_G107_L1.1120.95
17_L33_L1.0980.95
78_F138_L1.0720.94
89_L93_G1.0680.94
73_V83_W1.0500.93
62_I96_A1.0450.93
128_N131_Y1.0300.93
16_L68_G1.0250.93
45_F120_N1.0220.92
21_E24_L1.0120.92
2_L6_V1.0070.92
67_Q91_Y1.0040.92
9_L79_L0.9960.91
70_F77_A0.9560.90
58_A100_L0.9550.90
54_A110_P0.9480.89
4_F8_F0.9290.88
86_L140_L0.9210.88
59_T101_I0.9190.88
95_M98_N0.9100.87
66_F94_M0.9080.87
63_D131_Y0.9040.87
103_L125_L0.9010.87
67_Q98_N0.8950.86
33_L37_V0.8790.85
15_T68_G0.8730.85
62_I100_L0.8670.85
23_L60_I0.8650.84
54_A104_G0.8630.84
100_L104_G0.8590.84
124_V131_Y0.8520.84
54_A57_R0.8500.83
76_Y80_K0.8460.83
63_D124_V0.8430.83
35_D38_H0.8420.83
15_T71_Y0.8310.82
11_N14_I0.8300.82
137_L140_L0.8280.82
13_P17_L0.8190.81
104_G108_F0.8160.81
11_N71_Y0.8140.81
120_N123_K0.8110.80
77_A83_W0.8110.80
103_L132_L0.8090.80
34_V37_V0.8050.80
67_Q94_M0.8040.80
10_I131_Y0.7910.79
77_A87_P0.7840.78
48_L56_F0.7830.78
3_V10_I0.7830.78
130_P137_L0.7830.78
45_F123_K0.7810.78
67_Q128_N0.7800.78
63_D67_Q0.7770.77
63_D128_N0.7750.77
76_Y79_L0.7680.77
36_L39_W0.7670.77
84_I87_P0.7670.77
89_L94_M0.7660.76
78_F142_M0.7530.75
88_A138_L0.7520.75
80_K84_I0.7490.75
14_I18_V0.7480.75
21_E25_P0.7450.74
62_I95_M0.7420.74
32_P35_D0.7390.74
55_W102_I0.7350.73
66_F87_P0.7340.73
12_L16_L0.7330.73
2_L10_I0.7330.73
68_G71_Y0.7320.73
18_V21_E0.7250.72
99_V102_I0.7230.72
57_R104_G0.7220.72
98_N128_N0.7190.72
124_V128_N0.7170.72
11_N16_L0.7170.72
31_A66_F0.7160.72
3_V137_L0.7000.70
48_L53_P0.6920.69
127_A130_P0.6920.69
34_V38_H0.6870.68
96_A100_L0.6840.68
83_W87_P0.6800.68
58_A121_L0.6740.67
75_I79_L0.6500.64
95_M100_L0.6500.64
42_G50_L0.6480.64
63_D71_Y0.6450.64
95_M134_I0.6440.63
92_A96_A0.6410.63
31_A133_L0.6400.63
72_L76_Y0.6390.63
58_A94_M0.6380.63
7_F10_I0.6370.63
107_L122_L0.6340.62
122_L125_L0.6330.62
47_P109_G0.6310.62
13_P130_P0.6310.62
64_A80_K0.6260.61
77_A89_L0.6180.60
20_L25_P0.6180.60
46_D63_D0.6180.60
55_W101_I0.6160.60
88_A92_A0.6140.60
118_T121_L0.6050.59
82_N85_R0.6020.58
20_L23_L0.5980.58
108_F111_H0.5920.57
89_L139_L0.5920.57
39_W45_F0.5860.56
8_F91_Y0.5850.56
37_V40_Y0.5830.56
33_L36_L0.5810.56
38_H42_G0.5790.55
105_E109_G0.5770.55
97_T101_I0.5760.55
55_W121_L0.5690.54
40_Y123_K0.5680.54
66_F91_Y0.5680.54
5_L12_L0.5610.53
47_P106_E0.5560.52
71_Y74_A0.5550.52
1_D10_I0.5550.52
75_I129_L0.5550.52
74_A84_I0.5540.52
87_P92_A0.5480.51
28_L32_P0.5440.51
73_V84_I0.5440.51
95_M99_V0.5420.51
66_F74_A0.5380.50
1_D141_R0.5370.50
38_H41_I0.5360.50
54_A58_A0.5320.49
25_P29_W0.5190.48
82_N89_L0.5190.48
70_F84_I0.5170.47
36_L40_Y0.5160.47
86_L93_G0.5130.47
13_P16_L0.5120.47
53_P131_Y0.5100.46
125_L130_P0.5080.46
22_Q49_L0.5060.46
66_F97_T0.5050.46
9_L16_L0.5040.46
33_L130_P0.5020.45
59_T97_T0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wvfA 1 0.7103 1.2 0.957 Contact Map
2qjyA 2 0.2345 0.9 0.96 Contact Map
3wu2T 1 0.2069 0.9 0.96 Contact Map
3v2yA 1 0.8483 0.8 0.961 Contact Map
2vpzC 2 0.7103 0.7 0.962 Contact Map
4uc1A 3 0.869 0.7 0.962 Contact Map
2rh1A 1 0.8966 0.7 0.962 Contact Map
2kncA 1 0.2552 0.7 0.963 Contact Map
4z35A 1 0.9034 0.6 0.964 Contact Map
2hewF 3 0.2414 0.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.