GREMLIN Database
DUF2695 - Protein of unknown function (DUF2695)
PFAM: PF10905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (52)
Sequences: 2556 (1898)
Seq/√Len: 263.2
META: 0.953

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L40_E2.7511.00
25_L35_V2.4041.00
24_W28_R2.2951.00
38_W42_N2.1581.00
21_T50_V2.1561.00
15_D19_R1.8721.00
40_E45_Y1.7831.00
18_L50_V1.7221.00
26_D32_V1.6931.00
18_L36_L1.6221.00
25_L32_V1.6061.00
9_L13_G1.5341.00
22_R32_V1.4621.00
14_C46_C1.3751.00
22_R36_L1.3581.00
18_L44_G1.3461.00
36_L40_E1.2921.00
35_V39_L1.2421.00
14_C48_C1.2361.00
23_R27_E1.2261.00
44_G49_E1.1831.00
45_Y49_E1.1761.00
7_R11_E1.1481.00
32_V36_L1.1081.00
49_E53_N1.1071.00
21_T39_L1.0701.00
24_W38_W1.0311.00
2_F38_W1.0291.00
5_L9_L0.9871.00
33_E37_A0.9801.00
21_T25_L0.9701.00
38_W52_A0.9401.00
4_Y8_E0.9371.00
22_R26_D0.9311.00
25_L36_L0.9141.00
6_D10_E0.8991.00
45_Y53_N0.8931.00
4_Y24_W0.8871.00
34_A38_W0.8751.00
32_V35_V0.8300.99
3_D7_R0.8290.99
8_E23_R0.7790.99
8_E11_E0.7590.99
2_F6_D0.7480.99
25_L39_L0.7410.99
8_E12_E0.7350.99
33_E45_Y0.7340.99
25_L30_L0.7060.98
30_L35_V0.6970.98
3_D10_E0.6970.98
6_D11_E0.6870.98
18_L45_Y0.6800.98
8_E20_L0.6760.98
23_R26_D0.6670.97
22_R40_E0.6670.97
14_C17_T0.6620.97
9_L51_L0.6530.97
5_L51_L0.6440.97
24_W30_L0.6340.96
31_D37_A0.6320.96
31_D34_A0.5980.95
5_L20_L0.5970.95
19_R31_D0.5840.94
21_T24_W0.5810.94
5_L10_E0.5800.94
12_E20_L0.5760.94
19_R23_R0.5700.94
15_D20_L0.5650.93
38_W41_E0.5630.93
44_G53_N0.5570.93
3_D6_D0.5560.93
33_E41_E0.5270.91
44_G50_V0.5270.91
12_E23_R0.5260.91
25_L38_W0.5190.90
5_L8_E0.5150.90
37_A40_E0.5010.88
4_Y20_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xlgB 1 0.9057 6.8 0.864 Contact Map
1urjA 1 1 6.8 0.864 Contact Map
1z96A 1 0.6604 6.7 0.864 Contact Map
2z14A 2 0.6226 6.4 0.866 Contact Map
1pdnC 1 0.717 5.2 0.872 Contact Map
1rw1A 1 0.8302 5 0.872 Contact Map
3j7yg 1 0.8113 4.7 0.874 Contact Map
2dakA 1 0.7925 4.7 0.874 Contact Map
1o7dA 1 0.6981 4.4 0.875 Contact Map
2h21A 3 0.5094 4.2 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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