GREMLIN Database
DUF2693 - Protein of unknown function (DUF2693)
PFAM: PF10902 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (66)
Sequences: 2590 (2023)
Seq/√Len: 249.0
META: 0.986

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_K57_E3.2641.00
51_L66_V2.9411.00
18_K55_D2.2681.00
14_E70_I2.2561.00
17_M53_V2.2181.00
6_T16_V2.1231.00
55_D58_K1.8831.00
4_T16_V1.8621.00
10_K68_S1.8411.00
22_N25_L1.8281.00
8_T14_E1.8211.00
6_T14_E1.8081.00
10_K65_R1.7851.00
5_V19_C1.6851.00
47_N50_V1.6721.00
8_T70_I1.6681.00
54_W60_G1.6601.00
65_R68_S1.5311.00
4_T18_K1.5191.00
19_C53_V1.4721.00
64_F69_V1.3551.00
50_V65_R1.3431.00
7_F53_V1.2331.00
5_V17_M1.1871.00
6_T71_S1.1701.00
5_V53_V1.0801.00
29_A32_P1.0641.00
58_K62_R1.0571.00
45_K48_E1.0391.00
44_R47_N1.0181.00
39_E42_K1.0131.00
54_W59_N0.9971.00
39_E43_T0.9941.00
38_E41_K0.9781.00
17_M58_K0.9531.00
23_P31_K0.9521.00
6_T70_I0.9381.00
21_L51_L0.9311.00
7_F17_M0.9291.00
30_E33_K0.9181.00
26_I29_A0.9061.00
5_V64_F0.9021.00
49_D65_R0.8941.00
8_T68_S0.8721.00
13_T58_K0.8450.99
38_E42_K0.8310.99
8_T12_G0.8140.99
66_V69_V0.8050.99
52_A60_G0.7660.99
37_E43_T0.7650.99
5_V69_V0.7550.99
40_T43_T0.7530.99
27_P61_W0.7520.99
18_K56_L0.7470.98
28_E31_K0.7460.98
21_L66_V0.7330.98
10_K13_T0.7220.98
50_V63_S0.7160.98
29_A33_K0.7040.98
26_I61_W0.7030.98
37_E41_K0.6950.98
55_D60_G0.6880.97
33_K37_E0.6880.97
44_R52_A0.6840.97
46_E52_A0.6820.97
38_E43_T0.6800.97
23_P26_I0.6780.97
43_T46_E0.6780.97
4_T71_S0.6710.97
20_T61_W0.6640.97
32_P39_E0.6500.96
56_L59_N0.6390.96
49_D67_D0.6160.95
26_I33_K0.6120.95
37_E40_T0.6110.95
44_R48_E0.6060.95
53_V64_F0.6050.95
27_P32_P0.6000.94
60_G63_S0.5840.93
23_P28_E0.5770.93
5_V12_G0.5750.93
32_P37_E0.5680.93
46_E49_D0.5630.92
50_V67_D0.5540.92
42_K45_K0.5510.91
69_V72_V0.5450.91
41_K47_N0.5410.91
25_L56_L0.5400.91
42_K46_E0.5350.90
26_I51_L0.5290.90
52_A68_S0.5230.89
10_K66_V0.5220.89
23_P46_E0.5200.89
56_L60_G0.5160.88
6_T18_K0.5110.88
41_K46_E0.5080.88
15_R55_D0.5060.88
53_V62_R0.5000.87
26_I30_E0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h51A 2 0.3133 8.9 0.896 Contact Map
4m8rA 4 0.5542 5.4 0.906 Contact Map
4h75A 1 0.5422 4.7 0.909 Contact Map
4icwA 1 0.8916 4.2 0.911 Contact Map
3ke7A 2 0.3373 4.1 0.911 Contact Map
3k2tA 1 0.2289 4 0.912 Contact Map
4b9gA 1 0.3614 3.7 0.913 Contact Map
2ux0A 4 0.2892 3.7 0.914 Contact Map
1fztA 1 0.6747 3.5 0.915 Contact Map
2hz7A 1 0.9036 3.4 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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