GREMLIN Database
DUF2690 - Protein of unknown function (DUF2690)
PFAM: PF10901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (86)
Sequences: 974 (803)
Seq/√Len: 86.6
META: 0.476

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_E45_R5.6851.00
19_T34_R4.1231.00
16_D37_P3.6081.00
34_R45_R3.3901.00
6_K77_M3.3521.00
41_A79_A2.4701.00
32_E47_T2.1321.00
35_Y42_A2.1191.00
44_A75_T2.0641.00
7_D10_A1.8851.00
18_V37_P1.8251.00
23_T31_V1.8251.00
42_A80_V1.7471.00
40_G79_A1.6261.00
62_G65_R1.6011.00
7_D74_Y1.5071.00
40_G80_V1.4460.99
35_Y40_G1.4250.99
37_P40_G1.4110.99
65_R69_G1.4030.99
44_A55_V1.3210.99
50_A53_D1.2250.98
66_T69_G1.2130.98
24_A29_A1.1980.98
61_G65_R1.1970.98
36_S39_C1.1970.98
42_A78_V1.1960.98
32_E44_A1.1730.97
16_D38_T1.1550.97
60_R64_G1.1110.96
41_A77_M1.0920.96
3_C6_K1.0870.96
82_D85_T1.0770.95
45_R74_Y1.0710.95
13_C39_C1.0630.95
25_T28_G1.0530.95
24_A30_T1.0430.95
7_D12_G0.9810.93
8_P31_V0.9730.92
14_G34_R0.9490.91
81_P85_T0.9460.91
4_D8_P0.9320.91
31_V46_I0.9160.90
8_P74_Y0.9090.89
8_P72_D0.8990.89
51_P54_R0.8920.89
9_E34_R0.8720.87
6_K11_M0.8630.87
49_A53_D0.8590.87
32_E74_Y0.8580.87
3_C41_A0.8560.86
31_V59_A0.8470.86
19_T32_E0.8320.85
23_T28_G0.8310.85
80_V83_P0.8260.84
23_T26_V0.8170.84
59_A62_G0.8150.84
60_R63_D0.8120.83
57_V78_V0.8090.83
12_G15_G0.8050.83
62_G67_A0.7980.82
60_R68_A0.7460.78
59_A69_G0.7440.78
15_G18_V0.7360.77
40_G48_G0.7350.77
5_G75_T0.7260.76
52_G55_V0.7190.75
17_A20_T0.7160.75
6_K36_S0.7130.75
42_A88_A0.7130.75
17_A38_T0.7110.74
60_R67_A0.7050.74
16_D36_S0.6980.73
11_M77_M0.6960.73
7_D44_A0.6940.73
62_G69_G0.6930.72
28_G51_P0.6820.71
4_D79_A0.6720.70
56_E63_D0.6690.70
47_T72_D0.6660.70
44_A54_R0.6650.69
58_T66_T0.6580.69
58_T64_G0.6560.68
80_V86_A0.6560.68
21_A28_G0.6560.68
8_P20_T0.6470.67
4_D78_V0.6460.67
61_G67_A0.6450.67
43_W77_M0.6400.66
33_L42_A0.6400.66
59_A78_V0.6380.66
40_G83_P0.6320.65
22_S32_E0.6310.65
20_T75_T0.6300.65
51_P68_A0.6250.65
22_S44_A0.6210.64
21_A38_T0.6190.64
12_G74_Y0.6140.63
46_I49_A0.6030.62
19_T45_R0.5980.61
20_T26_V0.5970.61
53_D57_V0.5950.61
64_G67_A0.5940.61
9_E12_G0.5920.60
65_R68_A0.5890.60
42_A81_P0.5820.59
81_P86_A0.5820.59
46_I74_Y0.5770.59
16_D19_T0.5750.58
55_V58_T0.5750.58
14_G44_A0.5680.57
8_P14_G0.5600.56
6_K21_A0.5540.55
49_A69_G0.5520.55
41_A76_P0.5340.53
58_T87_R0.5310.52
63_D71_T0.5290.52
76_P79_A0.5280.52
25_T29_A0.5250.52
53_D70_D0.5250.52
17_A36_S0.5170.50
34_R74_Y0.5150.50
18_V21_A0.5110.50
3_C37_P0.5110.50
59_A75_T0.5090.49
61_G66_T0.5060.49
5_G78_V0.5010.48
8_P44_A0.5000.48
58_T68_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o30A 1 0.5393 3.1 0.917 Contact Map
2ykaB 1 0.2584 2.8 0.919 Contact Map
1lr7A 1 0.4494 1.1 0.936 Contact Map
1tbrR 1 0.4607 1 0.937 Contact Map
3bmzA 2 0.3483 0.9 0.94 Contact Map
2m5xA 1 0.427 0.9 0.94 Contact Map
1bndA 2 0.6629 0.8 0.94 Contact Map
4icvA 1 0.3933 0.8 0.941 Contact Map
2pmvA 1 0.3371 0.8 0.942 Contact Map
1wwwV 2 0.6067 0.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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