GREMLIN Database
AbiGi - Putative abortive phage resistance protein AbiGi, antitoxin
PFAM: PF10899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 190 (179)
Sequences: 740 (701)
Seq/√Len: 52.4
META: 0.819

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_R136_D3.6311.00
48_K132_K3.4611.00
120_E133_R3.0131.00
36_D58_K2.8951.00
165_K169_N2.6171.00
179_F183_D2.5711.00
67_N73_N2.4681.00
35_C45_H2.3531.00
117_K121_G2.3471.00
135_Y138_R2.3341.00
59_E63_K2.2431.00
154_L159_F2.2201.00
42_I46_I2.2101.00
169_N172_L2.1721.00
134_F144_P2.1571.00
136_D188_I2.0811.00
38_P135_Y2.0721.00
53_G188_I2.0441.00
118_P121_G1.9911.00
138_R188_I1.9611.00
154_L158_E1.9240.99
168_N171_K1.8730.99
67_N70_L1.8670.99
56_L179_F1.8490.99
121_G134_F1.8460.99
165_K168_N1.8330.99
32_V67_N1.8100.99
120_E131_N1.8030.99
57_S185_K1.7580.99
161_D165_K1.7480.99
123_L132_K1.6930.99
37_I42_I1.6550.98
153_L159_F1.5800.98
33_C132_K1.5720.98
33_C118_P1.5620.98
119_Y133_R1.5510.98
119_Y179_F1.5370.97
64_N180_E1.5310.97
35_C41_Q1.4910.97
113_L117_K1.4890.97
61_G185_K1.4850.97
49_Y137_E1.4750.97
63_K182_D1.4700.97
55_G67_N1.4610.97
58_K61_G1.4490.96
39_L55_G1.4230.96
75_N80_K1.4110.96
33_C123_L1.3910.95
56_L183_D1.3880.95
38_P42_I1.3830.95
7_Y10_E1.3770.95
35_C52_Y1.3680.95
55_G186_Y1.3580.95
41_Q138_R1.3430.94
11_D14_Y1.3300.94
5_P33_C1.3010.93
42_I53_G1.2900.93
30_P35_C1.2750.93
67_N78_L1.2680.92
40_S55_G1.2270.91
56_L64_N1.2120.91
119_Y136_D1.2090.91
35_C186_Y1.1990.90
15_L18_K1.1910.90
12_I15_L1.1810.90
33_C69_V1.1670.89
26_E156_E1.1470.88
6_R33_C1.1430.88
57_S172_L1.1410.88
56_L60_W1.1410.88
48_K123_L1.1320.87
46_I133_R1.1280.87
123_L134_F1.1090.86
52_Y57_S1.1010.86
118_P132_K1.1000.86
54_I187_I1.0910.85
155_S159_F1.0650.84
45_H53_G1.0590.84
7_Y12_I1.0500.83
73_N132_K1.0440.83
58_K119_Y1.0440.83
34_F140_W1.0420.83
166_N169_N1.0410.83
9_L12_I1.0330.82
134_F137_E1.0280.82
5_P11_D1.0210.81
35_C38_P1.0200.81
91_K96_I1.0150.81
33_C45_H1.0140.81
30_P144_P0.9980.80
9_L14_Y0.9950.80
158_E164_K0.9860.79
33_C36_D0.9840.79
36_D45_H0.9790.79
45_H58_K0.9790.79
84_E108_N0.9680.78
60_W64_N0.9660.78
82_L86_L0.9620.77
73_N135_Y0.9580.77
40_S186_Y0.9580.77
39_L45_H0.9540.77
67_N176_R0.9520.77
100_D131_N0.9500.76
124_K129_Y0.9480.76
62_I143_V0.9460.76
6_R12_I0.9430.76
166_N170_K0.9410.76
46_I136_D0.9380.76
41_Q119_Y0.9240.74
91_K158_E0.9230.74
72_I79_A0.9210.74
41_Q136_D0.9190.74
38_P55_G0.9080.73
97_F143_V0.9040.73
38_P186_Y0.9020.73
35_C136_D0.9010.73
56_L66_L0.8980.72
155_S158_E0.8940.72
55_G135_Y0.8920.72
78_L112_L0.8890.72
9_L28_A0.8830.71
161_D169_N0.8830.71
71_Y139_E0.8800.71
60_W117_K0.8800.71
35_C66_L0.8770.70
118_P123_L0.8770.70
13_S17_I0.8760.70
60_W179_F0.8750.70
45_H186_Y0.8650.69
37_I49_Y0.8570.69
6_R14_Y0.8550.69
8_C14_Y0.8530.68
62_I66_L0.8510.68
29_I41_Q0.8420.67
67_N135_Y0.8400.67
165_K172_L0.8390.67
44_E132_K0.8310.66
163_K185_K0.8240.66
34_F66_L0.8240.66
50_G136_D0.8160.65
5_P10_E0.8140.65
14_Y17_I0.8100.64
75_N160_T0.8100.64
42_I142_Y0.8070.64
57_S102_L0.8040.64
28_A39_L0.8030.64
57_S143_V0.7940.63
32_V181_P0.7880.62
145_D178_K0.7850.62
160_T164_K0.7780.61
66_L73_N0.7730.61
117_K134_F0.7640.60
57_S60_W0.7550.59
119_Y123_L0.7510.58
170_K173_K0.7510.58
58_K171_K0.7440.58
37_I45_H0.7400.57
5_P8_C0.7360.57
31_M36_D0.7350.57
133_R138_R0.7290.56
91_K161_D0.7260.56
17_I20_N0.7250.56
176_R187_I0.7250.56
61_G118_P0.7100.54
31_M143_V0.7100.54
45_H140_W0.7100.54
144_P186_Y0.7040.54
39_L42_I0.7040.54
179_F184_I0.7010.53
18_K69_V0.6950.53
66_L177_L0.6940.53
32_V56_L0.6890.52
69_V123_L0.6880.52
30_P137_E0.6870.52
35_C56_L0.6870.52
60_W121_G0.6860.52
14_Y19_K0.6760.51
48_K118_P0.6740.50
78_L82_L0.6700.50
117_K137_E0.6680.50
33_C41_Q0.6670.50
106_Y120_E0.6640.49
48_K136_D0.6640.49
151_L163_K0.6630.49
35_C137_E0.6630.49
71_Y140_W0.6630.49
66_L132_K0.6580.49
60_W142_Y0.6560.49
35_C61_G0.6540.48
44_E48_K0.6500.48
36_D119_Y0.6460.48
36_D135_Y0.6450.47
72_I82_L0.6340.46
12_I54_I0.6290.46
112_L117_K0.6260.45
152_P178_K0.6170.44
172_L176_R0.6130.44
60_W183_D0.6110.44
69_V103_D0.6070.43
28_A36_D0.6030.43
45_H55_G0.6020.43
6_R15_L0.6020.43
52_Y59_E0.6010.43
115_Y125_R0.6010.43
60_W66_L0.5970.42
102_L173_K0.5960.42
58_K140_W0.5950.42
35_C39_L0.5940.42
75_N109_L0.5920.42
6_R11_D0.5880.42
12_I19_K0.5880.42
123_L130_K0.5870.41
71_Y141_R0.5860.41
69_V138_R0.5810.41
40_S48_K0.5810.41
7_Y16_N0.5790.41
92_L182_D0.5770.40
121_G125_R0.5740.40
51_K54_I0.5720.40
63_K183_D0.5720.40
99_E102_L0.5680.39
76_S136_D0.5670.39
114_R135_Y0.5640.39
115_Y118_P0.5630.39
46_I53_G0.5610.39
173_K176_R0.5600.39
80_K174_K0.5590.39
142_Y158_E0.5590.39
29_I114_R0.5580.38
154_L168_N0.5570.38
57_S183_D0.5550.38
31_M189_V0.5520.38
100_D182_D0.5500.38
128_K178_K0.5490.38
8_C12_I0.5480.37
134_F142_Y0.5460.37
6_R123_L0.5450.37
91_K150_E0.5430.37
87_K109_L0.5410.37
119_Y125_R0.5400.37
167_K170_K0.5340.36
26_E172_L0.5320.36
79_A112_L0.5320.36
41_Q132_K0.5310.36
119_Y176_R0.5310.36
43_K85_L0.5290.36
11_D18_K0.5290.36
117_K144_P0.5250.35
98_K154_L0.5250.35
98_K156_E0.5210.35
36_D55_G0.5190.35
48_K121_G0.5180.35
62_I73_N0.5150.34
30_P52_Y0.5140.34
66_L173_K0.5140.34
42_I48_K0.5140.34
31_M35_C0.5130.34
88_K104_K0.5130.34
97_F101_E0.5090.34
131_N169_N0.5090.34
52_Y69_V0.5060.33
108_N182_D0.5050.33
12_I16_N0.5040.33
161_D168_N0.5030.33
41_Q123_L0.5030.33
151_L156_E0.5020.33
55_G138_R0.5010.33
46_I51_K0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4s0vA 1 0.4632 2.5 0.962 Contact Map
4mj7A 2 0.3421 2 0.963 Contact Map
2k1oA 2 0.1316 1.8 0.964 Contact Map
2xvoA 2 0.2947 1.7 0.965 Contact Map
1zk9A 2 0.2579 1.3 0.967 Contact Map
2y0nE 4 0.0737 1.3 0.968 Contact Map
2koeA 1 0.2105 1.2 0.968 Contact Map
3buxB 1 0.5263 1.1 0.969 Contact Map
3c6vA 3 0.3211 1.1 0.969 Contact Map
1m4uA 2 0.3368 1.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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