GREMLIN Database
DUF2703 - Domain of unknown function (DUF2703)
PFAM: PF10865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (119)
Sequences: 1471 (993)
Seq/√Len: 91.1
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E47_K4.4551.00
102_E107_E3.5851.00
24_E110_A3.3771.00
51_D55_F2.7561.00
31_E113_K2.6641.00
20_G110_A2.6251.00
84_C89_G2.4811.00
81_K100_T2.3691.00
58_D61_S2.3381.00
89_G92_C2.2891.00
15_C18_C2.2451.00
83_S100_T2.1671.00
100_T107_E2.1341.00
28_A117_V1.7461.00
4_E46_E1.7261.00
24_E27_E1.6911.00
22_G47_K1.6421.00
70_R74_E1.6081.00
52_T56_A1.5601.00
6_L64_T1.5531.00
65_I116_I1.5391.00
9_D49_E1.4420.99
34_P43_V1.4390.99
25_L29_V1.4320.99
4_E48_T1.4170.99
1_L67_I1.4080.99
43_V47_K1.3960.99
49_E55_F1.3860.99
84_C97_D1.3790.99
71_D76_L1.3580.99
53_E57_K1.3580.99
16_E86_E1.3380.99
10_L52_T1.3310.99
16_E87_S1.2850.99
14_T17_R1.2770.99
80_V84_C1.2700.99
51_D54_E1.2270.98
11_E19_G1.2060.98
4_E66_R1.1920.98
29_V43_V1.1850.98
24_E113_K1.1720.98
85_C88_C1.1580.97
2_V46_E1.1540.97
36_L43_V1.1470.97
61_S64_T1.1340.97
27_E113_K1.1340.97
6_L9_D1.1330.97
18_C88_C1.1310.97
87_S91_L1.1300.97
24_E116_I1.1260.97
6_L71_D1.1180.97
67_I70_R1.0980.96
64_T71_D1.0880.96
2_V44_E1.0860.96
20_G101_W1.0860.96
70_R75_W1.0710.96
66_R71_D1.0620.96
6_L48_T1.0280.95
33_R42_E1.0240.95
9_D59_F1.0190.95
57_K60_L1.0160.95
113_K116_I1.0100.94
24_E28_A0.9990.94
92_C96_V0.9950.94
14_T62_S0.9830.94
54_E61_S0.9810.93
32_L35_V0.9730.93
50_L55_F0.9690.93
24_E78_A0.9670.93
36_L41_I0.9540.93
28_A113_K0.9500.92
108_Y112_P0.9440.92
9_D64_T0.9360.92
88_C98_C0.9150.91
37_A70_R0.8940.90
79_E102_E0.8910.90
32_L38_P0.8820.89
84_C95_D0.8780.89
17_R83_S0.8660.88
3_I25_L0.8560.88
104_E118_E0.8490.87
26_E45_L0.8420.87
77_A80_V0.8360.87
34_P37_A0.8340.86
8_L92_C0.8270.86
54_E68_N0.8240.86
4_E69_G0.8220.86
14_T91_L0.8170.85
102_E105_G0.8080.85
2_V43_V0.8050.84
83_S97_D0.8040.84
6_L61_S0.8000.84
17_R88_C0.7980.84
4_E43_V0.7880.83
11_E14_T0.7810.83
17_R109_E0.7740.82
62_S99_R0.7690.82
62_S98_C0.7650.81
72_I116_I0.7510.80
41_I44_E0.7440.79
45_L49_E0.7420.79
7_Y49_E0.7390.79
67_I75_W0.7370.79
19_G23_E0.7290.78
63_N71_D0.7250.78
32_L117_V0.7240.78
41_I87_S0.7070.76
32_L39_L0.7070.76
2_V70_R0.7060.76
107_E116_I0.7030.75
46_E116_I0.6930.74
76_L111_I0.6930.74
16_E20_G0.6930.74
18_C62_S0.6920.74
55_F59_F0.6850.74
32_L109_E0.6840.73
103_Y118_E0.6810.73
113_K117_V0.6800.73
14_T109_E0.6700.72
35_V60_L0.6690.72
41_I94_D0.6570.70
83_S95_D0.6550.70
9_D13_E0.6510.70
40_G105_G0.6500.70
43_V68_N0.6490.70
56_A96_V0.6410.69
45_L92_C0.6370.68
78_A81_K0.6330.68
8_L55_F0.6320.68
77_A101_W0.6270.67
105_G118_E0.6240.67
17_R98_C0.6190.66
30_E57_K0.6160.66
62_S69_G0.6120.65
19_G22_G0.6040.64
65_I111_I0.5990.63
45_L108_Y0.5950.63
68_N71_D0.5910.62
48_T66_R0.5900.62
38_P43_V0.5880.62
64_T68_N0.5880.62
13_E65_I0.5850.62
18_C63_N0.5790.61
16_E109_E0.5780.61
2_V116_I0.5770.61
44_E57_K0.5770.61
10_L61_S0.5740.60
80_V83_S0.5740.60
92_C95_D0.5690.59
31_E35_V0.5630.59
44_E54_E0.5600.58
16_E57_K0.5590.58
13_E74_E0.5550.58
20_G87_S0.5530.57
12_G71_D0.5520.57
25_L75_W0.5520.57
23_E38_P0.5480.57
30_E97_D0.5470.57
71_D105_G0.5410.56
48_T58_D0.5400.56
25_L45_L0.5390.55
15_C88_C0.5360.55
17_R62_S0.5340.55
46_E54_E0.5270.54
23_E110_A0.5260.54
61_S111_I0.5240.53
30_E40_G0.5220.53
27_E30_E0.5210.53
6_L10_L0.5210.53
98_C109_E0.5200.53
86_E95_D0.5190.53
28_A67_I0.5120.52
58_D119_A0.5100.51
41_I86_E0.5070.51
17_R110_A0.5050.51
8_L62_S0.5050.51
109_E114_E0.5010.50
33_R37_A0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r6fA 2 0.9917 46.8 0.903 Contact Map
3pihA 2 0.85 29.1 0.913 Contact Map
2jvfA 1 0.6417 26.6 0.914 Contact Map
4mo1A 1 0.5083 26.3 0.915 Contact Map
3ipzA 3 0.675 24.9 0.916 Contact Map
1k82A 1 0.3333 24.4 0.916 Contact Map
2k8sA 2 0.6667 23.2 0.917 Contact Map
3u6pA 1 0.3083 22.2 0.918 Contact Map
2hzeA 1 0.6833 21.2 0.918 Contact Map
2vf7A 2 0.9083 20.2 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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