GREMLIN Database
DUF2784 - Protein of Unknown function (DUF2784)
PFAM: PF10861 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (110)
Sequences: 11829 (8398)
Seq/√Len: 800.7
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_W64_R4.5261.00
15_V83_L3.4721.00
51_I56_P2.7851.00
44_L48_L2.7711.00
44_L50_W2.7061.00
73_G76_E2.5381.00
45_I50_W2.4581.00
57_L60_W2.4141.00
18_V42_G2.3971.00
28_W31_L2.2281.00
14_F38_A2.2231.00
17_F31_L2.2031.00
7_V57_L2.1781.00
76_E80_L2.1721.00
97_V101_L1.8861.00
14_F18_V1.8261.00
7_V61_L1.7361.00
47_L97_V1.7041.00
59_N70_Y1.6441.00
39_I103_V1.6001.00
26_W29_P1.5461.00
93_R96_Q1.4781.00
17_F34_L1.4701.00
35_H39_I1.4501.00
33_W37_P1.4241.00
43_A47_L1.4171.00
22_G25_V1.4141.00
59_N69_G1.3331.00
99_L103_V1.3071.00
105_A109_L1.2971.00
58_E62_R1.2661.00
47_L100_G1.2571.00
16_L20_L1.2501.00
22_G110_V1.2061.00
34_L37_P1.1991.00
98_A102_L1.1981.00
25_V32_A1.1951.00
60_W63_R1.1941.00
70_Y77_H1.1821.00
62_R67_E1.1401.00
107_N111_Y1.1401.00
94_A98_A1.1301.00
17_F38_A1.1301.00
92_T96_Q1.1281.00
18_V38_A1.1191.00
29_P32_A1.0921.00
63_R69_G1.0881.00
107_N110_V1.0871.00
95_A98_A1.0821.00
26_W31_L1.0801.00
90_G94_A1.0731.00
72_G77_H1.0521.00
47_L101_L1.0321.00
102_L106_L1.0281.00
42_G45_I1.0271.00
88_P91_L1.0261.00
41_W45_I0.9911.00
94_A97_V0.9821.00
39_I42_G0.9781.00
99_L102_L0.9771.00
40_A44_L0.9721.00
5_D62_R0.9561.00
27_R31_L0.9461.00
34_L38_A0.9271.00
14_F42_G0.9201.00
8_L80_L0.9201.00
59_N72_G0.9191.00
29_P110_V0.9191.00
77_H81_P0.8991.00
3_L61_L0.8931.00
85_Y92_T0.8531.00
108_V111_Y0.8291.00
64_R67_E0.8271.00
80_L84_Y0.8251.00
45_I48_L0.8241.00
59_N77_H0.8231.00
56_P60_W0.8211.00
51_I59_N0.8161.00
6_A10_L0.8141.00
26_W110_V0.8041.00
87_A92_T0.7971.00
49_G93_R0.7831.00
17_F35_H0.7741.00
43_A46_E0.7691.00
41_W46_E0.7561.00
14_F41_W0.7541.00
12_L78_Y0.7541.00
12_L82_L0.7441.00
19_V102_L0.7341.00
58_E74_F0.7311.00
104_L108_V0.7281.00
24_L28_W0.7251.00
48_L51_I0.7211.00
93_R97_V0.7201.00
4_A8_L0.7131.00
37_P41_W0.7101.00
38_A42_G0.7071.00
18_V103_V0.6991.00
98_A101_L0.6981.00
103_V107_N0.6971.00
103_V106_L0.6881.00
42_G46_E0.6851.00
43_A100_G0.6821.00
18_V39_I0.6741.00
12_L79_L0.6611.00
29_P33_W0.6591.00
76_E89_A0.6531.00
91_L95_A0.6481.00
99_L106_L0.6481.00
89_A93_R0.6441.00
106_L111_Y0.6421.00
23_L110_V0.6391.00
91_L94_A0.6381.00
19_V22_G0.6301.00
15_V75_I0.6271.00
96_Q100_G0.6271.00
45_I53_P0.6241.00
79_L92_T0.6211.00
101_L105_A0.6191.00
20_L23_L0.6171.00
23_L26_W0.6171.00
2_L6_A0.6131.00
4_A61_L0.6111.00
28_W32_A0.6101.00
59_N71_S0.6061.00
11_H52_C0.6041.00
41_W48_L0.5931.00
86_D89_A0.5891.00
3_L7_V0.5871.00
63_R71_S0.5811.00
67_E71_S0.5761.00
36_L40_A0.5731.00
80_L86_D0.5731.00
24_L31_L0.5721.00
13_A16_L0.5711.00
72_G80_L0.5711.00
39_I100_G0.5681.00
36_L39_I0.5661.00
32_A37_P0.5571.00
84_Y88_P0.5571.00
31_L34_L0.5521.00
22_G106_L0.5511.00
3_L6_A0.5471.00
41_W50_W0.5461.00
30_R33_W0.5451.00
95_A99_L0.5441.00
72_G76_E0.5441.00
57_L61_L0.5411.00
56_P59_N0.5391.00
25_V29_P0.5381.00
21_G38_A0.5361.00
59_N63_R0.5321.00
74_F84_Y0.5301.00
105_A108_V0.5281.00
106_L110_V0.5281.00
17_F24_L0.5261.00
106_L109_L0.5251.00
46_E84_Y0.5231.00
15_V19_V0.5161.00
74_F78_Y0.5141.00
45_I51_I0.5121.00
2_L5_D0.5081.00
88_P92_T0.5061.00
12_L15_V0.5011.00
12_L83_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rh5C 1 0.2857 18.1 0.889 Contact Map
4he8H 1 0.5625 11 0.899 Contact Map
4od4A 1 0.8571 4.1 0.917 Contact Map
2kv5A 1 0.2946 4 0.918 Contact Map
2ww9C 1 0.1875 3.3 0.921 Contact Map
4b19A 1 0.2679 2.8 0.924 Contact Map
2mpnA 2 0.5089 2.3 0.927 Contact Map
4q4hA 1 0.3304 2.1 0.929 Contact Map
2wwbC 1 0.2946 2 0.93 Contact Map
2mmuA 1 0.1964 1.8 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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