GREMLIN Database
DUF2577 - Protein of unknown function (DUF2577)
PFAM: PF10844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (91)
Sequences: 1412 (1160)
Seq/√Len: 121.6
META: 0.767

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_I90_V3.2561.00
24_S29_K2.8731.00
45_L49_V2.5431.00
21_T76_K2.3211.00
39_T42_F2.0991.00
25_V73_V2.0961.00
46_T49_V2.0511.00
28_L45_L2.0411.00
75_D93_R2.0341.00
31_Q37_T2.0271.00
29_K39_T2.0211.00
23_T31_Q2.0061.00
47_E50_T1.9741.00
20_G79_L1.9401.00
23_T37_T1.8751.00
6_L9_V1.8081.00
29_K37_T1.7871.00
65_G68_G1.6191.00
38_L43_L1.5421.00
18_L79_L1.5161.00
46_T92_D1.5061.00
60_H63_E1.4141.00
38_L42_F1.3891.00
60_H67_G1.3731.00
56_I60_H1.3291.00
80_L91_L1.2921.00
5_A8_A1.2791.00
82_V89_I1.2430.99
62_T65_G1.2370.99
55_E59_D1.2290.99
19_F44_I1.2110.99
51_D54_V1.2080.99
17_I80_L1.1810.99
17_I78_L1.1620.99
23_T29_K1.1220.99
26_S74_G1.1160.99
51_D70_G1.1150.99
4_A8_A1.1090.99
22_V27_P1.0790.98
81_R85_G1.0630.98
18_L88_Y1.0610.98
78_L89_I1.0490.98
20_G30_I1.0430.98
58_V62_T1.0420.98
79_L90_V1.0260.98
65_G69_S1.0150.98
66_T69_S0.9740.97
61_G65_G0.9490.97
44_I78_L0.9330.96
6_L11_A0.9330.96
19_F78_L0.9290.96
57_T61_G0.9290.96
6_L10_E0.9280.96
25_V70_G0.9260.96
22_V71_L0.9250.96
82_V87_K0.9220.96
48_N52_Y0.9080.96
43_L90_V0.9050.95
25_V77_V0.8990.95
21_T31_Q0.8860.95
6_L12_S0.8830.95
25_V40_E0.8740.95
82_V91_L0.8630.94
21_T74_G0.8600.94
63_E67_G0.8510.94
46_T91_L0.8450.93
47_E92_D0.8390.93
8_A11_A0.8360.93
60_H66_T0.8330.93
4_A7_E0.8290.93
60_H64_T0.8280.93
48_N92_D0.8270.93
61_G64_T0.8180.92
5_A9_V0.8110.92
62_T69_S0.8060.92
7_E10_E0.8020.92
15_V83_Q0.7940.91
33_D36_L0.7890.91
14_P83_Q0.7860.91
26_S40_E0.7820.91
47_E75_D0.7560.89
61_G66_T0.7520.89
11_A73_V0.7480.89
78_L92_D0.7460.88
46_T89_I0.7450.88
3_K6_L0.7350.88
45_L48_N0.7260.87
58_V61_G0.7230.87
26_S70_G0.7090.86
13_K81_R0.7030.85
34_Q89_I0.6990.85
17_I89_I0.6970.85
5_A14_P0.6820.83
22_V25_V0.6770.83
55_E60_H0.6740.83
49_V71_L0.6660.82
59_D65_G0.6410.80
62_T68_G0.6380.79
44_I87_K0.6370.79
9_V13_K0.6210.77
61_G67_G0.6200.77
64_T68_G0.6170.77
46_T78_L0.6160.77
63_E69_S0.6110.76
22_V30_I0.6100.76
55_E69_S0.6070.76
19_F76_K0.5990.75
22_V28_L0.5940.74
19_F33_D0.5900.74
36_L88_Y0.5890.74
60_H65_G0.5880.73
55_E61_G0.5850.73
47_E93_R0.5840.73
59_D67_G0.5790.72
27_P43_L0.5770.72
3_K7_E0.5720.71
58_V63_E0.5720.71
62_T66_T0.5650.71
9_V12_S0.5620.70
78_L91_L0.5580.70
9_V24_S0.5490.68
72_K75_D0.5490.68
30_I43_L0.5470.68
59_D63_E0.5450.68
61_G68_G0.5440.68
64_T67_G0.5360.67
18_L61_G0.5270.65
21_T25_V0.5190.64
53_T57_T0.5180.64
15_V81_R0.5170.64
54_V60_H0.5170.64
84_G87_K0.5160.64
51_D55_E0.5110.63
19_F89_I0.5080.62
16_D83_Q0.5000.61
16_D81_R0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qwbA 2 0.9355 22.2 0.87 Contact Map
2c0cA 1 0.957 22.1 0.87 Contact Map
3gg8A 3 0.871 19.1 0.874 Contact Map
4pj1O 3 0.8065 18.8 0.874 Contact Map
3nx6A 1 0.5484 17.2 0.876 Contact Map
1a3wA 3 0.8925 17.2 0.876 Contact Map
2b25A 3 0.2151 16.8 0.877 Contact Map
4rvuA 2 0.9355 16 0.878 Contact Map
3pqiA 3 0.7312 16 0.878 Contact Map
2cdcA 3 0.8817 14.9 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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