GREMLIN Database
DUF2568 - Protein of unknown function (DUF2568)
PFAM: PF10823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 92 (90)
Sequences: 4418 (3589)
Seq/√Len: 378.3
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_A67_V3.4051.00
14_L39_A3.1371.00
3_R64_E2.8081.00
19_W32_A2.3771.00
60_R64_E2.3461.00
11_L40_A2.3021.00
45_L53_V2.2981.00
72_A88_A2.1791.00
42_V63_L2.1411.00
8_L12_A1.9031.00
13_A75_L1.8371.00
55_L59_V1.8331.00
39_A67_V1.7871.00
47_A63_L1.7001.00
10_A71_A1.6811.00
13_A78_A1.6091.00
82_V86_V1.5931.00
51_A54_R1.5111.00
25_T29_I1.4511.00
76_A81_P1.4431.00
22_G31_L1.3591.00
17_W35_A1.3191.00
19_W28_R1.2881.00
40_A44_G1.2861.00
76_A84_A1.2801.00
47_A64_E1.2401.00
16_Y78_A1.2281.00
57_G61_L1.2231.00
25_T28_R1.1911.00
17_W74_A1.1851.00
87_F91_A1.1671.00
6_L9_A1.1641.00
17_W77_A1.1411.00
73_A77_A1.1201.00
12_A15_G1.1191.00
3_R6_L1.1191.00
46_F53_V1.1041.00
16_Y80_Q1.1021.00
15_G36_P1.1021.00
14_L70_L1.0731.00
81_P85_V1.0631.00
45_L52_P1.0491.00
42_V46_F1.0371.00
48_A51_A1.0261.00
32_A36_P1.0251.00
41_V45_L1.0171.00
61_L64_E1.0141.00
47_A60_R0.9991.00
42_V47_A0.9681.00
12_A16_Y0.9501.00
68_F91_A0.9471.00
22_G28_R0.9431.00
15_G19_W0.9311.00
14_L35_A0.9291.00
18_G36_P0.9261.00
47_A67_V0.9211.00
11_L36_P0.9201.00
75_L83_L0.9131.00
48_A53_V0.9111.00
27_L30_L0.9041.00
10_A39_A0.9041.00
10_A47_A0.9041.00
4_F7_E0.8951.00
57_G60_R0.8931.00
18_G22_G0.8891.00
85_V89_V0.8731.00
72_A84_A0.8731.00
47_A57_G0.8711.00
2_L90_V0.8611.00
22_G27_L0.8521.00
48_A55_L0.8381.00
14_L71_A0.8351.00
5_L9_A0.8281.00
55_L63_L0.8151.00
33_I36_P0.7991.00
80_Q83_L0.7981.00
64_E68_F0.7951.00
27_L31_L0.7881.00
3_R47_A0.7761.00
72_A87_F0.7751.00
37_L40_A0.7741.00
14_L74_A0.7661.00
47_A50_K0.7641.00
47_A51_A0.7601.00
33_I37_L0.7321.00
9_A12_A0.7281.00
21_T31_L0.7241.00
88_A91_A0.7020.99
73_A76_A0.7000.99
23_D28_R0.6800.99
53_V59_V0.6780.99
20_T80_Q0.6770.99
70_L74_A0.6760.99
24_G28_R0.6750.99
59_V62_L0.6720.99
86_V89_V0.6630.99
4_F8_L0.6360.99
69_G72_A0.6320.99
12_A75_L0.6270.99
20_T23_D0.6270.99
31_L36_P0.6260.99
9_A13_A0.6250.99
82_V85_V0.6220.99
17_W21_T0.6210.99
13_A71_A0.6180.99
35_A70_L0.6120.99
66_V70_L0.6060.99
24_G27_L0.6060.99
49_P54_R0.6010.98
42_V67_V0.6010.98
45_L51_A0.6000.98
19_W29_I0.5930.98
10_A68_F0.5890.98
6_L68_F0.5860.98
2_L6_L0.5670.98
46_F55_L0.5660.98
64_E69_G0.5620.98
87_F90_V0.5620.98
28_R32_A0.5600.98
9_A87_F0.5550.97
65_L69_G0.5520.97
71_A87_F0.5490.97
6_L90_V0.5370.97
54_R59_V0.5370.97
2_L5_L0.5360.97
29_I32_A0.5310.97
74_A77_A0.5230.96
48_A52_P0.5210.96
13_A83_L0.5120.96
12_A83_L0.5090.96
19_W33_I0.5050.95
35_A74_A0.5030.95
31_L35_A0.5020.95
18_G35_A0.5010.95
45_L48_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hznA 1 0.3043 1.2 0.917 Contact Map
2mpnA 2 0.4565 1.1 0.919 Contact Map
1zcdA 1 0.5109 1.1 0.921 Contact Map
2lx0A 1 0.2717 0.9 0.923 Contact Map
4xnjA 1 0.5761 0.9 0.925 Contact Map
4ujrT 1 0.2609 0.9 0.925 Contact Map
2mmuA 1 0.337 0.7 0.928 Contact Map
4ub6R 1 0.3696 0.7 0.929 Contact Map
2wa0A 1 0.2826 0.7 0.929 Contact Map
2ksfA 1 0.663 0.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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