GREMLIN Database
DUF2760 - Domain of unknown function (DUF2760)
PFAM: PF10816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (122)
Sequences: 3407 (2110)
Seq/√Len: 191.0
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_A99_R3.3791.00
65_R90_R3.2951.00
22_M49_R3.2831.00
55_E101_T3.1941.00
70_A86_Q2.9741.00
45_R49_R2.7951.00
73_D76_A2.6881.00
39_V42_E2.6521.00
15_G44_C2.6311.00
67_T90_R2.6091.00
20_F41_H2.5771.00
61_E64_S2.5731.00
53_T102_K2.4941.00
17_L21_L2.3701.00
53_T101_T2.1771.00
58_R77_I2.1531.00
10_L51_H1.8591.00
52_F103_V1.8271.00
58_R66_V1.8201.00
54_L117_I1.7481.00
37_V40_V1.7141.00
60_E64_S1.6671.00
29_S32_Q1.6661.00
56_P96_R1.6261.00
10_L47_V1.6041.00
15_G21_L1.4791.00
28_Y32_Q1.4631.00
26_A42_E1.4501.00
25_I33_I1.4311.00
79_L83_V1.4291.00
39_V43_G1.4241.00
14_E46_K1.4201.00
85_G89_F1.4181.00
6_Q10_L1.4081.00
100_A103_V1.3461.00
66_V93_L1.3411.00
23_E28_Y1.2991.00
57_V99_R1.2871.00
55_E59_D1.2831.00
24_D27_G1.2371.00
18_V22_M1.2211.00
53_T104_K1.2031.00
3_G6_Q1.1831.00
68_V77_I1.1771.00
22_M45_R1.1491.00
85_G88_P1.1121.00
65_R92_T1.1081.00
68_V122_V1.1061.00
93_L120_A1.1041.00
28_Y36_A1.0811.00
108_L114_A1.0631.00
18_V21_L1.0501.00
68_V79_L1.0481.00
58_R93_L1.0211.00
55_E99_R1.0121.00
29_S33_I1.0091.00
78_R121_E1.0061.00
7_L18_V1.0041.00
47_V52_F0.9960.99
4_A7_L0.9940.99
79_L87_P0.9890.99
42_E46_K0.9870.99
6_Q9_A0.9730.99
50_E104_K0.9590.99
60_E93_L0.9170.99
60_E66_V0.9100.99
113_D116_V0.9040.99
34_G42_E0.8930.99
63_G94_R0.8840.99
72_F89_F0.8740.99
28_Y37_V0.8730.99
73_D116_V0.8460.98
5_L100_A0.8440.98
25_I41_H0.8330.98
46_K49_R0.8280.98
99_R115_R0.8220.98
40_V43_G0.8210.98
23_E50_E0.8200.98
68_V74_P0.8160.98
28_Y33_I0.8140.98
8_L18_V0.8100.98
108_L111_G0.8030.98
14_E47_V0.8000.98
11_L21_L0.7900.97
17_L36_A0.7880.97
17_L48_L0.7770.97
26_A45_R0.7760.97
71_G85_G0.7580.97
84_T87_P0.7560.97
68_V72_F0.7490.96
99_R113_D0.7450.96
41_H44_C0.7440.96
79_L91_G0.7360.96
59_D96_R0.7360.96
71_G87_P0.7360.96
7_L52_F0.7290.96
112_Q115_R0.7100.95
18_V48_L0.7030.95
78_R92_T0.7000.95
25_I39_V0.6960.95
6_Q96_R0.6900.94
75_A109_P0.6890.94
5_L113_D0.6890.94
10_L23_E0.6890.94
72_F80_T0.6890.94
21_L48_L0.6890.94
39_V80_T0.6890.94
37_V41_H0.6880.94
21_L44_C0.6870.94
108_L117_I0.6760.94
57_V120_A0.6750.94
103_V115_R0.6750.94
62_E96_R0.6740.94
17_L44_C0.6730.94
72_F77_I0.6720.94
34_G38_R0.6720.94
52_F117_I0.6660.93
48_L54_L0.6600.93
13_R94_R0.6530.93
4_A14_E0.6490.92
20_F37_V0.6440.92
31_A34_G0.6390.92
46_K50_E0.6360.92
47_V51_H0.6330.91
33_I36_A0.6270.91
15_G42_E0.6260.91
77_I120_A0.6100.90
58_R76_A0.6080.90
72_F76_A0.6060.90
47_V50_E0.6020.89
68_V89_F0.6020.89
68_V120_A0.6010.89
110_E113_D0.5980.89
55_E92_T0.5950.89
84_T89_F0.5930.89
68_V85_G0.5930.89
43_G50_E0.5910.88
23_E78_R0.5880.88
60_E65_R0.5880.88
52_F100_A0.5850.88
72_F78_R0.5840.88
13_R51_H0.5840.88
69_P76_A0.5840.88
51_H105_L0.5810.88
68_V88_P0.5790.87
111_G114_A0.5770.87
51_H109_P0.5640.86
52_F108_L0.5630.86
101_T104_K0.5600.86
56_P94_R0.5490.84
58_R96_R0.5470.84
7_L10_L0.5460.84
86_Q107_K0.5450.84
94_R123_E0.5440.84
40_V44_C0.5420.84
49_R53_T0.5420.84
30_D34_G0.5390.83
15_G47_V0.5380.83
72_F79_L0.5370.83
32_Q39_V0.5340.83
7_L39_V0.5330.83
50_E96_R0.5300.82
93_L96_R0.5270.82
4_A13_R0.5260.82
78_R94_R0.5210.81
4_A10_L0.5200.81
21_L25_I0.5170.81
32_Q37_V0.5160.81
24_D29_S0.5150.81
18_V54_L0.5110.80
10_L94_R0.5110.80
8_L11_L0.5090.80
62_E67_T0.5080.80
32_Q36_A0.5070.80
46_K114_A0.5060.79
67_T72_F0.5040.79
10_L105_L0.5020.79
25_I28_Y0.5020.79
106_P118_A0.5020.79
10_L13_R0.5010.79
73_D113_D0.5010.79
43_G78_R0.5000.79
83_V91_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ckzA 1 0.3496 16.4 0.945 Contact Map
4aniA 2 0.8049 11.5 0.948 Contact Map
3a6mA 2 0.7886 11.1 0.949 Contact Map
2gkpA 1 0.3496 8.9 0.951 Contact Map
1wjtA 1 0.5285 8 0.952 Contact Map
4xbiA 1 0.8699 7.1 0.953 Contact Map
3g13A 2 0.5691 6.7 0.953 Contact Map
2hn1A 2 0.3984 5.9 0.955 Contact Map
3jqoA 7 0.4878 5.8 0.955 Contact Map
3bqwA 1 0.7236 5.6 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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