GREMLIN Database
DUF2599 - Protein of unknown function (DUF2599)
PFAM: PF10783 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (92)
Sequences: 742 (520)
Seq/√Len: 54.2
META: 0.65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_A54_F4.3691.00
81_S84_E2.7941.00
18_Y70_S2.6971.00
17_V73_L2.6921.00
84_E88_A2.5421.00
82_D86_V2.5161.00
14_S74_E2.4941.00
52_A82_D2.1371.00
81_S85_M2.1081.00
82_D85_M2.0221.00
20_T23_G1.9341.00
52_A81_S1.9141.00
52_A85_M1.8910.99
7_V16_R1.8440.99
15_L50_M1.8410.99
68_K72_N1.8180.99
19_P24_R1.7900.99
15_L75_P1.7040.99
6_W15_L1.6450.99
51_R55_V1.6360.98
80_V92_P1.5750.98
21_A25_A1.5700.98
12_G76_W1.5400.98
52_A79_V1.4870.97
57_H65_A1.4430.97
31_A55_V1.3190.94
14_S72_N1.3110.94
32_D51_R1.2840.94
24_R70_S1.2670.93
14_S75_P1.2280.92
61_A65_A1.2000.91
41_L45_A1.1790.90
85_M92_P1.1490.89
77_R80_V1.1130.87
22_A35_W1.0920.86
3_H18_Y1.0780.86
80_V85_M1.0730.85
83_A87_A1.0730.85
9_R12_G1.0680.85
77_R92_P1.0650.85
60_F86_V1.0360.83
53_Q56_C1.0250.83
49_G75_P1.0210.82
17_V76_W0.9950.81
11_D47_T0.9820.80
28_P31_A0.9660.79
23_G27_A0.9510.78
28_P55_V0.9450.77
26_A30_A0.9440.77
4_A38_V0.9270.76
9_R16_R0.9160.75
85_M88_A0.9120.75
20_T37_E0.8890.73
32_D36_A0.8770.72
7_V13_S0.8760.72
82_D88_A0.8660.71
39_L43_P0.8530.70
34_A37_E0.8480.69
8_K11_D0.8310.68
80_V84_E0.8270.67
59_Q63_L0.8190.67
61_A74_E0.8190.67
59_Q82_D0.8120.66
4_A17_V0.8080.65
39_L42_A0.7990.65
65_A68_K0.7970.64
17_V37_E0.7930.64
8_K26_A0.7880.64
8_K81_S0.7740.62
11_D76_W0.7730.62
27_A69_T0.7670.61
59_Q86_V0.7660.61
79_V82_D0.7650.61
33_E36_A0.7440.59
49_G85_M0.7430.59
52_A59_Q0.7360.58
12_G92_P0.7310.58
86_V89_G0.7250.57
38_V42_A0.7220.57
50_M68_K0.7150.56
26_A58_W0.7090.55
8_K13_S0.6980.54
16_R70_S0.6910.53
3_H9_R0.6880.53
5_E8_K0.6820.53
49_G52_A0.6750.52
35_W54_F0.6740.52
72_N75_P0.6660.51
23_G37_E0.6640.51
40_A55_V0.6610.50
16_R72_N0.6570.50
1_I26_A0.6560.50
60_F65_A0.6530.49
43_P50_M0.6520.49
47_T50_M0.6450.49
4_A10_G0.6410.48
27_A30_A0.6320.47
13_S25_A0.6280.47
49_G78_P0.6260.47
11_D17_V0.6250.46
41_L60_F0.6240.46
39_L46_D0.6220.46
9_R13_S0.6210.46
35_W45_A0.6190.46
38_V54_F0.6180.46
22_A79_V0.6160.46
23_G54_F0.6100.45
53_Q90_C0.6070.45
65_A69_T0.6010.44
24_R51_R0.5980.44
38_V70_S0.5970.44
39_L44_D0.5960.43
6_W73_L0.5930.43
16_R67_G0.5930.43
34_A58_W0.5930.43
33_E87_A0.5810.42
56_C90_C0.5750.41
61_A64_A0.5700.41
16_R73_L0.5680.40
58_W66_P0.5680.40
46_D49_G0.5530.39
55_V59_Q0.5440.38
35_W46_D0.5430.38
11_D52_A0.5370.37
38_V49_G0.5330.37
31_A51_R0.5320.37
35_W38_V0.5320.37
1_I13_S0.5300.37
11_D59_Q0.5290.37
39_L50_M0.5270.36
64_A86_V0.5200.36
50_M75_P0.5120.35
55_V76_W0.5080.35
14_S26_A0.5080.35
17_V22_A0.5070.34
7_V10_G0.5040.34
57_H72_N0.5030.34
28_P59_Q0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g32A 1 0.9677 7.3 0.918 Contact Map
3f6vA 2 0.5161 3.7 0.929 Contact Map
3n40P 1 0.3978 3.1 0.931 Contact Map
3d3lA 1 0.6882 2.6 0.934 Contact Map
4nreA 4 0.8817 2 0.938 Contact Map
3rdeA 4 0.9247 2 0.938 Contact Map
2cjqA 1 0.0108 1.8 0.94 Contact Map
1mr1C 1 0.3978 1.8 0.94 Contact Map
1loxA 1 0.8602 1.8 0.94 Contact Map
1hsjA 2 0.4301 1.7 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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