GREMLIN Database
FliX - Class II flagellar assembly regulator
PFAM: PF10768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (133)
Sequences: 2589 (1837)
Seq/√Len: 159.3
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_E129_A3.8821.00
112_S118_D3.3881.00
82_D85_K2.9861.00
109_R122_D2.8571.00
86_L90_S2.7661.00
126_L129_A2.7251.00
77_L128_A2.5101.00
113_G118_D2.5081.00
80_A83_E2.3251.00
87_G97_T2.3141.00
119_A123_E2.1531.00
13_S16_R2.0541.00
74_G124_I1.9961.00
80_A100_R1.9771.00
77_L105_V1.9211.00
95_P99_A1.9201.00
103_A107_E1.8601.00
97_T100_R1.8011.00
68_R71_V1.7801.00
83_E97_T1.7271.00
99_A103_A1.7011.00
67_R71_V1.6981.00
6_P9_T1.6461.00
55_A58_G1.6181.00
109_R125_E1.5771.00
122_D126_L1.5581.00
70_A121_L1.5391.00
74_G121_L1.5181.00
106_A129_A1.4921.00
100_R103_A1.4891.00
103_A106_A1.4721.00
60_E65_E1.4651.00
8_G11_A1.4581.00
83_E100_R1.3951.00
85_K123_E1.3921.00
18_A21_A1.3821.00
93_L98_L1.3691.00
14_A17_A1.3631.00
116_G120_V1.3511.00
54_L57_Q1.3451.00
131_E134_K1.3301.00
120_V123_E1.2971.00
76_D104_A1.2741.00
83_E87_G1.2671.00
119_A122_D1.2631.00
41_A44_P1.2631.00
105_V122_D1.2381.00
125_E134_K1.2191.00
62_D65_E1.2101.00
102_A106_A1.2051.00
9_T12_A1.1731.00
121_L125_E1.1731.00
93_L97_T1.1671.00
63_P66_R1.1651.00
77_L80_A1.1621.00
46_A49_G1.1341.00
87_G132_L1.1121.00
82_D86_L1.0760.99
130_V133_A1.0690.99
130_V134_K1.0630.99
127_R131_E1.0540.99
16_R19_R1.0440.99
93_L135_L1.0390.99
15_A21_A1.0370.99
80_A97_T1.0370.99
127_R130_V1.0270.99
94_P97_T1.0030.99
102_A129_A1.0010.99
4_Y8_G1.0000.99
87_G90_S0.9900.99
105_V109_R0.9880.99
2_R7_N0.9830.99
51_D56_L0.9810.99
4_Y7_N0.9710.99
12_A15_A0.9690.99
22_G92_T0.9590.99
87_G93_L0.9570.99
118_D122_D0.9510.99
80_A84_L0.9500.99
118_D126_L0.9390.98
82_D134_K0.9390.98
125_E128_A0.9330.98
105_V108_L0.9320.98
105_V121_L0.9310.98
13_S18_A0.9240.98
28_L32_A0.9230.98
73_R110_E0.9200.98
49_G58_G0.9170.98
75_R79_D0.9100.98
126_L130_V0.9090.98
75_R86_L0.8820.98
74_G77_L0.8650.97
71_V120_V0.8580.97
73_R77_L0.8530.97
29_P32_A0.8150.96
94_P135_L0.8100.96
29_P36_A0.8080.96
73_R109_R0.8030.96
82_D90_S0.7990.96
23_G27_S0.7980.96
17_A21_A0.7960.96
100_R107_E0.7960.96
67_R134_K0.7930.96
47_V51_D0.7880.95
128_A132_L0.7780.95
84_L92_T0.7740.95
14_A19_R0.7660.95
60_E63_P0.7640.95
67_R112_S0.7630.95
132_L135_L0.7590.94
59_V74_G0.7500.94
22_G29_P0.7490.94
7_N10_A0.7380.94
73_R107_E0.7350.93
18_A22_G0.7330.93
10_A29_P0.7270.93
51_D54_L0.7110.92
80_A101_L0.7100.92
76_D107_E0.7090.92
2_R6_P0.7080.92
10_A15_A0.7060.92
13_S17_A0.7060.92
75_R80_A0.7040.92
62_D66_R0.7030.92
101_L128_A0.6980.92
71_V134_K0.6940.91
58_G62_D0.6860.91
3_I80_A0.6820.91
11_A15_A0.6810.91
102_A105_V0.6760.90
92_T135_L0.6750.90
9_T33_A0.6720.90
1_M4_Y0.6690.90
85_K89_L0.6690.90
77_L108_L0.6580.89
34_A52_A0.6480.88
76_D97_T0.6280.87
104_A107_E0.6280.87
76_D83_E0.6280.87
69_R110_E0.6160.86
72_R75_R0.6140.86
123_E134_K0.6130.85
65_E68_R0.6130.85
73_R106_A0.6120.85
67_R113_G0.6050.85
53_L56_L0.5990.84
5_G10_A0.5960.84
52_A58_G0.5950.84
114_D120_V0.5900.83
10_A13_S0.5890.83
3_I54_L0.5850.83
122_D125_E0.5850.83
84_L87_G0.5790.82
52_A70_A0.5780.82
85_K134_K0.5780.82
14_A20_R0.5740.81
38_A73_R0.5740.81
29_P99_A0.5700.81
14_A18_A0.5670.81
63_P85_K0.5630.80
63_P67_R0.5620.80
108_L118_D0.5620.80
31_E43_A0.5600.80
79_D82_D0.5590.80
21_A39_A0.5580.80
62_D69_R0.5560.79
98_L135_L0.5550.79
19_R22_G0.5540.79
40_A111_S0.5500.79
102_A122_D0.5480.78
4_Y10_A0.5440.78
32_A66_R0.5440.78
87_G94_P0.5420.78
109_R128_A0.5380.77
39_A104_A0.5380.77
28_L56_L0.5370.77
37_A40_A0.5330.77
67_R85_K0.5300.76
50_I95_P0.5280.76
129_A135_L0.5270.76
11_A18_A0.5270.76
62_D68_R0.5260.76
8_G132_L0.5250.75
55_A85_K0.5230.75
12_A19_R0.5210.75
127_R133_A0.5200.75
99_A102_A0.5200.75
108_L128_A0.5170.74
78_L123_E0.5150.74
59_V62_D0.5150.74
60_E69_R0.5130.74
2_R8_G0.5120.74
20_R23_G0.5100.73
31_E115_P0.5100.73
42_A45_R0.5070.73
12_A41_A0.5060.73
46_A68_R0.5030.72
41_A47_V0.5020.72
69_R125_E0.5010.72
32_A41_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4errA 2 0.5735 16.4 0.913 Contact Map
1zl8A 1 0.3897 12.8 0.917 Contact Map
1e6yB 2 0.3676 9.2 0.922 Contact Map
2y1nA 1 0.4632 7.1 0.926 Contact Map
1hbnB 2 0.3897 5.3 0.93 Contact Map
3sqgB 2 0.3603 4.8 0.931 Contact Map
3iqtA 1 0.7279 4.3 0.933 Contact Map
2rbdA 4 0.3309 3.7 0.935 Contact Map
2a0bA 1 0.6765 3.6 0.935 Contact Map
2d9dA 1 0.5074 3.6 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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