GREMLIN Database
DUF2587 - Protein of unknown function (DUF2587)
PFAM: PF10759 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 159 (137)
Sequences: 2232 (677)
Seq/√Len: 57.8
META: 0.843

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_R126_E8.0761.00
45_E89_E4.1931.00
127_Q130_R3.0551.00
55_H63_E2.6211.00
116_A122_R2.6201.00
36_E39_R2.4881.00
43_L92_L2.4831.00
125_L128_M2.1811.00
63_E71_R2.0571.00
17_L67_S1.9791.00
71_R75_E1.9571.00
63_E75_E1.8661.00
121_A124_Q1.8451.00
52_R75_E1.8330.99
42_P89_E1.8320.99
123_A127_Q1.7020.99
17_L69_E1.6570.99
56_E60_K1.6370.99
112_A130_R1.6000.99
60_K63_E1.5820.98
31_I108_H1.5760.98
123_A130_R1.5690.98
49_A86_T1.5360.98
47_S96_Q1.5100.98
112_A123_A1.4850.98
14_V18_V1.4480.97
114_L128_M1.4290.97
28_G32_K1.4240.97
31_I107_F1.3980.97
25_M50_R1.3870.96
56_E75_E1.3790.96
138_P143_G1.3510.96
12_E16_E1.3510.96
24_V28_G1.3330.96
38_V46_A1.3330.96
19_E110_I1.3260.95
118_Q124_Q1.3260.95
115_F126_E1.3250.95
115_F119_M1.3170.95
25_M33_Q1.3120.95
27_I58_S1.2830.95
39_R47_S1.2780.94
22_A28_G1.2730.94
140_G143_G1.2690.94
93_R107_F1.2510.94
74_L100_V1.2030.92
71_R77_L1.2000.92
9_D12_E1.1780.92
136_G139_P1.1610.91
62_L66_L1.1540.91
19_E76_R1.1530.91
29_S89_E1.1500.91
23_K61_E1.1480.91
115_F125_L1.1440.90
52_R56_E1.1400.90
29_S32_K1.1250.90
32_K39_R1.1180.89
34_L116_A1.1170.89
28_G65_G1.1120.89
138_P141_G1.1010.89
57_R71_R1.0960.88
19_E119_M1.0770.88
52_R78_S1.0690.87
49_A52_R1.0590.87
13_S16_E1.0510.86
47_S77_L1.0350.85
57_R79_L1.0290.85
34_L78_S1.0280.85
42_P46_A1.0160.84
28_G81_F1.0090.84
138_P142_P1.0060.84
75_E82_T1.0050.84
49_A65_G1.0010.83
137_G140_G0.9950.83
125_L129_R0.9850.82
57_R60_K0.9720.82
41_A96_Q0.9700.81
119_M122_R0.9620.81
8_E11_E0.9590.81
14_V94_I0.9550.80
137_G142_P0.9500.80
33_Q113_A0.9470.80
55_H67_S0.9220.78
59_I63_E0.9210.78
68_P71_R0.9110.77
68_P114_L0.9040.77
24_V47_S0.9000.76
32_K57_R0.8980.76
22_A34_L0.8970.76
71_R76_R0.8930.76
14_V17_L0.8910.76
38_V108_H0.8830.75
32_K104_E0.8750.74
7_E10_E0.8700.74
28_G33_Q0.8700.74
51_L94_I0.8680.74
81_F92_L0.8630.73
8_E18_V0.8600.73
65_G76_R0.8360.71
46_A96_Q0.8300.70
50_R91_E0.8300.70
52_R84_D0.8150.69
115_F130_R0.8030.68
121_A128_M0.8030.68
32_K115_F0.8010.67
8_E13_S0.7980.67
20_Q65_G0.7930.67
61_E76_R0.7880.66
139_P142_P0.7860.66
82_T85_E0.7710.64
24_V34_L0.7610.63
21_P27_I0.7590.63
7_E11_E0.7570.63
58_S108_H0.7500.62
57_R115_F0.7470.62
9_D88_S0.7310.60
115_F123_A0.7280.60
55_H79_L0.7270.60
95_A116_A0.7260.60
22_A45_E0.7170.59
27_I64_D0.7160.59
128_M131_A0.7130.58
18_V107_F0.7120.58
20_Q108_H0.7110.58
119_M133_P0.7100.58
10_E13_S0.7080.58
28_G116_A0.7080.58
108_H116_A0.7060.58
55_H69_E0.7050.58
93_R108_H0.6890.56
49_A123_A0.6880.56
53_E56_E0.6880.56
79_L108_H0.6870.56
82_T94_I0.6830.55
74_L129_R0.6820.55
86_T89_E0.6820.55
47_S57_R0.6780.55
27_I32_K0.6770.55
15_T72_E0.6730.54
65_G71_R0.6730.54
62_L96_Q0.6670.53
31_I77_L0.6620.53
50_R80_P0.6550.52
47_S68_P0.6450.51
17_L20_Q0.6350.50
14_V67_S0.6340.50
12_E64_D0.6310.49
53_E60_K0.6270.49
137_G143_G0.6260.49
27_I107_F0.6220.48
120_A123_A0.6220.48
11_E88_S0.6170.48
64_D115_F0.6160.48
139_P143_G0.6160.48
136_G143_G0.6160.48
115_F118_Q0.6130.47
50_R94_I0.6080.47
52_R57_R0.6070.47
29_S113_A0.6070.47
78_S90_A0.6020.46
24_V76_R0.5970.46
96_Q113_A0.5910.45
42_P92_L0.5900.45
16_E68_P0.5880.45
137_G141_G0.5880.45
56_E67_S0.5860.45
81_F87_P0.5830.44
132_L135_G0.5830.44
57_R63_E0.5820.44
127_Q137_G0.5810.44
46_A86_T0.5800.44
136_G141_G0.5790.44
31_I116_A0.5780.44
9_D13_S0.5780.44
12_E15_T0.5760.43
46_A82_T0.5740.43
18_V24_V0.5730.43
60_K76_R0.5730.43
31_I78_S0.5700.43
56_E83_E0.5630.42
106_L110_I0.5560.41
60_K82_T0.5540.41
57_R125_L0.5540.41
47_S78_S0.5530.41
16_E20_Q0.5410.40
30_M100_V0.5400.40
60_K72_E0.5350.39
13_S134_P0.5310.39
53_E106_L0.5290.38
72_E75_E0.5260.38
93_R110_I0.5230.38
55_H76_R0.5200.38
45_E86_T0.5190.37
49_A53_E0.5190.37
58_S104_E0.5140.37
114_L125_L0.5120.37
46_A88_S0.5120.37
77_L115_F0.5090.36
80_P104_E0.5080.36
93_R96_Q0.5070.36
65_G123_A0.5050.36
121_A125_L0.5040.36
20_Q41_A0.5030.36
72_E76_R0.5020.36
72_E137_G0.5000.35
8_E12_E0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zriC 1 0.1258 10.7 0.957 Contact Map
1zbpA 1 0.8176 4.3 0.964 Contact Map
4bjjB 1 0.434 3.5 0.966 Contact Map
4zrkE 1 0.1384 3.5 0.966 Contact Map
2qneA 2 0.3648 3.4 0.966 Contact Map
2a01A 1 0.6981 3.2 0.966 Contact Map
4yycA 2 0.3711 3 0.967 Contact Map
4bzjA 2 0 2.9 0.967 Contact Map
4xpmA 1 0.2453 2.7 0.967 Contact Map
4uqxA 1 0.8365 2.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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