GREMLIN Database
DUF2585 - Protein of unknown function (DUF2585)
PFAM: PF10755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (162)
Sequences: 3829 (2348)
Seq/√Len: 184.4
META: 0.946

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_S109_A3.7351.00
116_L120_L3.2561.00
132_L136_L2.4551.00
149_L158_I2.4551.00
38_S136_L2.3501.00
135_V139_W2.3491.00
2_L100_V2.2641.00
26_E30_H2.1711.00
80_P84_N2.1681.00
71_A107_I2.1641.00
76_L81_F2.1281.00
72_A76_L2.0701.00
63_L111_A2.0281.00
19_H26_E1.9791.00
7_P11_T1.9731.00
32_A109_A1.9251.00
54_A57_L1.8971.00
122_V126_V1.8951.00
22_V27_N1.8671.00
41_I132_L1.8291.00
2_L8_P1.8291.00
105_S109_A1.8211.00
137_L143_N1.8141.00
9_I15_V1.7901.00
125_S129_A1.7901.00
84_N88_A1.7791.00
44_F128_L1.7731.00
67_V111_A1.7671.00
121_P124_A1.7221.00
41_I129_A1.6921.00
50_L65_L1.6801.00
131_A135_V1.6261.00
50_L54_A1.6221.00
44_F129_A1.5731.00
51_W55_R1.5681.00
37_F136_L1.4911.00
19_H24_S1.4901.00
156_E159_K1.4831.00
156_E160_A1.4811.00
85_R151_L1.4801.00
105_S108_L1.4761.00
45_L49_L1.4701.00
57_L61_W1.4651.00
16_K26_E1.4521.00
16_K30_H1.4231.00
48_G51_W1.4211.00
44_F125_S1.3991.00
45_L129_A1.3721.00
134_L138_L1.3681.00
31_L105_S1.3461.00
57_L65_L1.3421.00
58_P61_W1.3301.00
120_L124_A1.3221.00
136_L139_W1.2851.00
63_L67_V1.2791.00
90_T150_M1.2681.00
128_L132_L1.2661.00
48_G52_L1.2511.00
101_L105_S1.2391.00
61_W64_L1.2321.00
150_M159_K1.2081.00
50_L62_R1.2051.00
89_A92_S1.2001.00
41_I44_F1.1991.00
14_Y26_E1.1411.00
59_V114_F1.1391.00
32_A36_S1.1331.00
67_V71_A1.1251.00
145_T149_L1.1071.00
45_L48_G1.0961.00
159_K163_A1.0901.00
51_W62_R1.0871.00
108_L111_A1.0801.00
79_T82_V1.0661.00
84_N96_Y1.0581.00
155_I158_I1.0561.00
50_L69_I1.0501.00
132_L135_V1.0491.00
41_I136_L1.0491.00
45_L148_I1.0421.00
67_V107_I1.0421.00
118_R121_P1.0311.00
104_V108_L1.0301.00
10_C16_K1.0301.00
20_G32_A1.0291.00
111_A115_L1.0231.00
130_V134_L1.0221.00
16_K19_H1.0221.00
59_V118_R1.0171.00
19_H27_N1.0150.99
90_T159_K1.0080.99
21_V24_S0.9910.99
49_L69_I0.9870.99
68_L75_I0.9770.99
52_L55_R0.9740.99
34_W139_W0.9710.99
9_I30_H0.9680.99
40_I116_L0.9640.99
82_V85_R0.9540.99
10_C30_H0.9520.99
68_L72_A0.9490.99
46_F70_E0.9480.99
85_R89_A0.9300.99
112_L116_L0.9230.99
76_L82_V0.9030.99
9_I26_E0.8970.99
50_L66_A0.8950.99
22_V91_I0.8930.99
19_H30_H0.8830.99
11_T94_G0.8820.99
9_I101_L0.8810.99
80_P96_Y0.8740.98
7_P99_S0.8690.98
64_L68_L0.8600.98
2_L6_R0.8590.98
15_V30_H0.8320.98
31_L101_L0.8310.98
155_I159_K0.8310.98
88_A91_I0.8270.98
19_H25_S0.8270.98
120_L125_S0.8250.98
64_L67_V0.8230.98
10_C14_Y0.8200.98
50_L57_L0.8120.98
12_C15_V0.8050.97
155_I160_A0.7850.97
15_V26_E0.7840.97
86_Y147_N0.7750.97
19_H22_V0.7730.97
123_W127_A0.7730.97
17_L20_G0.7690.97
63_L114_F0.7680.97
42_H70_E0.7520.96
93_L96_Y0.7510.96
37_F132_L0.7510.96
4_M8_P0.7510.96
38_S70_E0.7490.96
134_L137_L0.7490.96
58_P62_R0.7490.96
47_Y121_P0.7440.96
116_L128_L0.7400.96
137_L146_L0.7350.96
11_T14_Y0.7290.95
15_V101_L0.7270.95
14_Y19_H0.7180.95
12_C25_S0.7110.95
54_A60_G0.7110.95
21_V27_N0.7090.95
12_C16_K0.7070.95
108_L112_L0.7070.95
137_L145_T0.7060.95
66_A110_M0.7040.94
30_H101_L0.7000.94
9_I12_C0.6990.94
4_M79_T0.6980.94
14_Y30_H0.6980.94
112_L115_L0.6960.94
134_L145_T0.6940.94
60_G64_L0.6920.94
40_I44_F0.6920.94
52_L56_R0.6880.94
135_V138_L0.6850.94
75_I79_T0.6800.93
160_A163_A0.6790.93
25_S30_H0.6780.93
27_N30_H0.6730.93
65_L68_L0.6720.93
124_A127_A0.6710.93
55_R62_R0.6680.93
89_A150_M0.6640.93
49_L53_V0.6620.92
40_I109_A0.6590.92
129_A145_T0.6570.92
129_A148_I0.6550.92
54_A65_L0.6520.92
121_P125_S0.6500.92
104_V107_I0.6470.92
24_S27_N0.6470.92
115_L118_R0.6400.91
59_V63_L0.6390.91
36_S40_I0.6380.91
6_R23_W0.6290.90
4_M80_P0.6250.90
70_E147_N0.6190.90
89_A93_L0.6160.90
81_F85_R0.6140.89
59_V115_L0.6140.89
37_F135_V0.6040.89
76_L79_T0.6030.89
131_A138_L0.6000.88
47_Y62_R0.5970.88
154_P159_K0.5910.88
157_A160_A0.5900.87
131_A136_L0.5880.87
152_I155_I0.5880.87
88_A92_S0.5860.87
123_W126_V0.5850.87
6_R11_T0.5850.87
42_H87_R0.5850.87
72_A75_I0.5830.87
80_P88_A0.5820.87
27_N91_I0.5810.87
49_L127_A0.5770.86
109_A112_L0.5700.86
60_G68_L0.5660.85
90_T93_L0.5650.85
37_F40_I0.5610.85
91_I150_M0.5600.85
136_L153_H0.5600.85
23_W89_A0.5580.84
101_L104_V0.5540.84
129_A132_L0.5500.84
19_H34_W0.5480.83
38_S45_L0.5450.83
70_E87_R0.5450.83
118_R125_S0.5450.83
69_I72_A0.5420.83
149_L155_I0.5410.83
37_F139_W0.5400.82
70_E86_Y0.5400.82
64_L115_L0.5380.82
124_A128_L0.5300.81
91_I96_Y0.5300.81
92_S150_M0.5280.81
85_R154_P0.5240.81
4_M75_I0.5230.80
31_L34_W0.5210.80
38_S42_H0.5210.80
76_L80_P0.5180.80
137_L158_I0.5170.80
54_A61_W0.5150.79
9_I16_K0.5140.79
16_K20_G0.5140.79
20_G27_N0.5130.79
115_L119_R0.5120.79
130_V160_A0.5120.79
47_Y59_V0.5100.79
89_A159_K0.5100.79
38_S41_I0.5100.79
25_S75_I0.5050.78
48_G110_M0.5040.78
41_I143_N0.5020.78
59_V62_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t6qA 1 0.3354 4.6 0.97 Contact Map
4p8sA 1 0.3354 3.2 0.972 Contact Map
3vq2A 2 0.2256 2.9 0.973 Contact Map
2dw3A 1 0.2866 2.4 0.974 Contact Map
2mdlA 1 0.061 2.4 0.974 Contact Map
3qryB 1 0.5 1.7 0.976 Contact Map
3hdxA 1 0.3354 1.6 0.976 Contact Map
2ksfA 1 0.2927 1.6 0.976 Contact Map
3ks7A 3 0.3598 1.4 0.977 Contact Map
2epbA 1 0.3293 1.3 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.