GREMLIN Database
DUF2569 - Protein of unknown function (DUF2569)
PFAM: PF10754 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 143 (142)
Sequences: 3183 (2827)
Seq/√Len: 237.2
META: 0.861

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_L132_F4.3451.00
3_G140_N3.8111.00
12_A74_F3.3051.00
85_F132_F3.0181.00
86_I133_L3.0051.00
16_V75_F2.8571.00
130_P134_R2.8141.00
125_A129_I2.7071.00
81_F132_F2.4761.00
72_V76_R2.3691.00
126_A130_P2.2471.00
85_F89_L2.2231.00
59_L95_F1.9311.00
90_L129_I1.8811.00
5_G137_R1.7871.00
136_K140_N1.7821.00
66_F70_L1.7631.00
20_L24_L1.7211.00
4_I12_A1.7051.00
10_L14_G1.6881.00
137_R141_T1.6811.00
82_P86_I1.6401.00
3_G141_T1.6281.00
4_I74_F1.6201.00
9_I13_I1.6121.00
117_E120_R1.6021.00
125_A130_P1.5971.00
56_E99_D1.5441.00
68_I72_V1.5151.00
52_L56_E1.4651.00
81_F85_F1.4631.00
39_W43_T1.4531.00
86_I129_I1.4131.00
93_L125_A1.4061.00
12_A75_F1.3701.00
82_P85_F1.3681.00
135_S138_V1.3481.00
67_S88_F1.2931.00
14_G128_W1.2701.00
120_R124_A1.2631.00
83_R87_I1.2581.00
11_L81_F1.2481.00
18_S22_L1.2371.00
88_F92_S1.2171.00
113_E116_R1.2121.00
87_I91_A1.2101.00
70_L81_F1.1951.00
15_L70_L1.1851.00
14_G124_A1.1831.00
116_R120_R1.1791.00
19_P22_L1.1681.00
56_E60_N1.1581.00
127_I130_P1.1441.00
66_F84_L1.1401.00
19_P67_S1.1331.00
70_L88_F1.1311.00
15_L88_F1.1061.00
43_T46_G1.0881.00
15_L71_L1.0821.00
74_F81_F1.0751.00
12_A142_F1.0621.00
99_D103_A1.0581.00
15_L85_F1.0431.00
71_L75_F1.0361.00
131_Y137_R1.0311.00
4_I142_F1.0271.00
73_L77_R1.0241.00
11_L128_W1.0161.00
22_L26_L1.0101.00
69_Y73_L1.0051.00
67_S70_L1.0011.00
73_L84_L0.9941.00
43_T50_A0.9931.00
11_L85_F0.9931.00
89_L92_S0.9801.00
21_R25_S0.9761.00
92_S96_L0.9551.00
2_K140_N0.9471.00
85_F88_F0.9441.00
69_Y84_L0.9401.00
71_L74_F0.9381.00
37_G40_A0.9361.00
73_L80_S0.9351.00
129_I133_L0.9341.00
51_P54_I0.9331.00
14_G18_S0.9331.00
67_S71_L0.9301.00
111_D114_A0.9231.00
132_F138_V0.9141.00
24_L28_S0.9101.00
44_T47_S0.9091.00
13_I16_V0.9081.00
70_L85_F0.8900.99
19_P23_L0.8850.99
102_L105_L0.8830.99
120_R128_W0.8760.99
73_L81_F0.8720.99
58_V62_A0.8660.99
69_Y80_S0.8650.99
26_L64_L0.8560.99
10_L13_I0.8550.99
11_L82_P0.8510.99
51_P55_F0.8510.99
100_A104_S0.8410.99
101_L105_L0.8400.99
70_L132_F0.8400.99
74_F142_F0.8370.99
83_R86_I0.8240.99
66_F88_F0.8220.99
80_S83_R0.8090.99
93_L122_L0.8080.99
40_A44_T0.7980.99
23_L27_F0.7870.99
3_G11_L0.7780.99
103_A107_F0.7760.99
45_P51_P0.7750.99
71_L81_F0.7710.99
12_A81_F0.7630.98
90_L94_V0.7560.98
111_D115_I0.7470.98
101_L104_S0.7450.98
77_R142_F0.7430.98
89_L125_A0.7390.98
12_A71_L0.7320.98
124_A130_P0.7260.98
12_A19_P0.7160.98
3_G136_K0.7110.97
19_P71_L0.7080.97
38_T41_A0.7040.97
129_I132_F0.6990.97
37_G41_A0.6980.97
124_A127_I0.6980.97
10_L128_W0.6960.97
19_P141_T0.6900.97
79_R143_V0.6900.97
120_R130_P0.6870.97
111_D117_E0.6850.97
5_G140_N0.6830.97
43_T47_S0.6740.97
8_L131_Y0.6720.96
15_L67_S0.6690.96
65_A69_Y0.6680.96
92_S122_L0.6680.96
114_A117_E0.6650.96
63_L91_A0.6550.96
18_S67_S0.6500.96
121_S124_A0.6480.96
57_L61_L0.6470.96
130_P133_L0.6470.96
60_N95_F0.6440.96
12_A16_V0.6420.95
4_I9_I0.6400.95
129_I142_F0.6340.95
97_L118_L0.6320.95
110_L114_A0.6270.95
5_G9_I0.6230.95
78_R82_P0.6230.95
120_R123_I0.6220.95
26_L31_S0.6130.94
49_W54_I0.6110.94
33_L78_R0.6090.94
36_P40_A0.6050.94
15_L132_F0.6040.94
39_W50_A0.6010.94
101_L106_I0.6000.94
115_I120_R0.5910.93
48_L51_P0.5910.93
59_L66_F0.5910.93
55_F59_L0.5850.93
8_L138_V0.5840.93
89_L132_F0.5800.92
63_L67_S0.5780.92
96_L100_A0.5780.92
119_I126_A0.5760.92
5_G141_T0.5760.92
86_I138_V0.5760.92
42_L49_W0.5750.92
69_Y72_V0.5750.92
66_F72_V0.5740.92
13_I17_L0.5720.92
81_F142_F0.5700.92
33_L40_A0.5700.92
132_F139_K0.5700.92
22_L60_N0.5680.92
64_L68_I0.5650.91
11_L14_G0.5590.91
74_F78_R0.5550.91
26_L109_A0.5540.91
80_S84_L0.5540.91
16_V19_P0.5510.90
29_S32_P0.5480.90
94_V97_L0.5470.90
4_I75_F0.5450.90
64_L67_S0.5450.90
15_L74_F0.5440.90
2_K101_L0.5430.90
93_L97_L0.5420.90
61_L65_A0.5380.89
89_L93_L0.5360.89
59_L91_A0.5350.89
91_A95_F0.5340.89
70_L84_L0.5310.89
16_V71_L0.5290.88
12_A15_L0.5290.88
46_G49_W0.5220.88
70_L74_F0.5150.87
38_T43_T0.5140.87
22_L63_L0.5120.87
5_G117_E0.5090.87
25_S28_S0.5070.86
44_T51_P0.5050.86
59_L113_E0.5020.86
123_I130_P0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.3077 6.1 0.908 Contact Map
2jwaA 2 0.3077 5.8 0.909 Contact Map
1iijA 1 0.2448 4.2 0.915 Contact Map
4qndA 2 0.6643 3.9 0.916 Contact Map
4qncA 2 0.5524 3.4 0.918 Contact Map
4ev6A 3 0.4685 3.2 0.92 Contact Map
2ks1B 1 0.3077 3.1 0.92 Contact Map
4i0uA 4 0.4126 2.7 0.923 Contact Map
4hygA 3 0.8531 2.6 0.923 Contact Map
2k1kA 2 0.2657 2.6 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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