GREMLIN Database
DUF2530 - Protein of unknown function (DUF2530)
PFAM: PF10745 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (70)
Sequences: 1340 (815)
Seq/√Len: 97.4
META: 0.757

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_A49_L4.0411.00
10_L13_P2.6801.00
20_G23_L2.3391.00
53_L57_A2.1741.00
28_L46_L2.1741.00
23_L27_A1.7961.00
31_L41_W1.7791.00
18_A22_A1.7631.00
60_R64_R1.6791.00
69_G72_G1.6321.00
36_D39_D1.4941.00
62_Q66_A1.4871.00
63_R66_A1.4391.00
25_A46_L1.4040.99
43_W46_L1.3750.99
57_A61_W1.3580.99
31_L42_L1.3290.99
28_L49_L1.3280.99
35_R45_C1.3190.99
34_V37_A1.3130.99
27_A45_C1.3040.99
28_L42_L1.2680.99
28_L45_C1.2550.99
35_R38_L1.2520.99
58_I62_Q1.2080.98
21_T49_L1.2080.98
46_L49_L1.1650.98
54_L58_I1.1570.98
65_A68_R1.1510.98
8_P11_L1.1150.97
65_A72_G1.1140.97
5_P11_L1.1060.97
59_F62_Q1.0920.97
29_V33_V1.0800.97
38_L41_W1.0750.97
15_P18_A1.0340.96
23_L26_V1.0270.96
12_D15_P1.0190.96
33_V36_D1.0020.95
64_R67_R0.9960.95
51_L58_I0.9860.95
14_V18_A0.9780.94
6_L11_L0.9380.93
61_W65_A0.9380.93
18_A56_L0.9360.93
35_R39_D0.9310.93
31_L45_C0.9270.93
39_D42_L0.9210.92
16_V50_G0.9140.92
50_G54_L0.9010.92
37_A40_A0.8940.91
26_V40_A0.8880.91
6_L9_L0.8780.91
32_L42_L0.8620.90
26_V30_V0.8600.90
27_A31_L0.8390.89
24_W45_C0.8340.88
17_V20_G0.8330.88
6_L10_L0.8190.87
34_V38_L0.8190.87
30_V34_V0.8060.86
59_F66_A0.8030.86
11_L15_P0.7850.85
20_G64_R0.7830.85
12_D16_V0.7780.84
64_R68_R0.7620.83
43_W47_A0.7560.83
21_T56_L0.7420.82
23_L55_G0.7180.79
32_L38_L0.7160.79
21_T47_A0.7000.78
4_P7_P0.7000.78
10_L15_P0.6990.78
64_R70_A0.6970.77
14_V22_A0.6950.77
9_L12_D0.6930.77
56_L60_R0.6840.76
34_V40_A0.6710.75
33_V37_A0.6660.74
32_L41_W0.6390.71
17_V59_F0.6290.70
17_V51_L0.6280.70
14_V56_L0.6260.69
9_L22_A0.6190.69
38_L42_L0.6030.67
20_G30_V0.6030.67
19_V22_A0.6020.66
6_L13_P0.5990.66
15_P19_V0.5870.65
51_L57_A0.5800.64
9_L60_R0.5730.63
28_L43_W0.5700.62
61_W64_R0.5660.62
16_V51_L0.5620.61
51_L55_G0.5450.59
61_W70_A0.5380.58
23_L72_G0.5300.57
62_Q65_A0.5250.56
16_V44_T0.5230.56
48_G55_G0.5200.55
21_T63_R0.5170.55
51_L54_L0.5140.55
21_T54_L0.5140.55
34_V64_R0.5090.54
28_L31_L0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fbzA 3 0.5844 10.4 0.887 Contact Map
2kluA 1 0.5714 9.1 0.89 Contact Map
2x2zA 1 0.1688 7.8 0.894 Contact Map
2l2tA 2 0.5325 7.7 0.894 Contact Map
3o7qA 1 0.987 7 0.895 Contact Map
2gfpA 2 0.987 6.3 0.898 Contact Map
1ohfA 8 0.7922 6.2 0.898 Contact Map
4j05A 3 0.987 6.2 0.898 Contact Map
1pw4A 1 0.987 5.4 0.901 Contact Map
3l1lA 2 0.8312 5.3 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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