GREMLIN Database
DUF2550 - Protein of unknown function (DUF2550)
PFAM: PF10739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (127)
Sequences: 1985 (1261)
Seq/√Len: 111.9
META: 0.716

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_R106_E4.2701.00
114_L118_L3.4911.00
77_G97_E3.2001.00
14_R18_L3.1851.00
97_E104_P2.8531.00
79_R85_E2.7851.00
109_M117_F2.7561.00
43_G54_W2.7501.00
16_R20_R2.3601.00
59_S62_P2.2501.00
14_R20_R2.2441.00
47_Y116_G2.0481.00
100_T103_G2.0421.00
99_R104_P2.0111.00
96_V114_L1.9791.00
46_R53_E1.9411.00
41_R56_R1.9141.00
81_P95_V1.8851.00
33_P36_G1.8451.00
69_S72_G1.8211.00
72_G101_G1.8051.00
48_S51_E1.7491.00
53_E67_V1.6891.00
46_R55_Y1.6541.00
90_P93_A1.6141.00
76_V99_R1.6131.00
51_E67_V1.6061.00
74_E99_R1.5521.00
13_V17_L1.5461.00
72_G83_G1.5131.00
121_L127_G1.5101.00
16_R19_L1.4381.00
8_L12_A1.3441.00
118_L124_A1.3000.99
25_F47_Y1.2540.99
98_C105_V1.2520.99
73_L98_C1.2500.99
12_A20_R1.2460.99
113_A116_G1.2300.99
110_S113_A1.2230.99
45_A116_G1.2130.99
115_T126_P1.1810.99
75_V118_L1.1630.99
5_L8_L1.1570.99
42_L57_L1.1510.99
29_L41_R1.1500.99
116_G121_L1.1490.99
38_R112_S1.1330.99
76_V97_E1.1290.98
3_L7_L1.0990.98
48_S53_E1.0970.98
60_L75_V1.0790.98
28_S42_L1.0520.98
58_F85_E1.0400.97
13_V18_L1.0390.97
45_A52_L1.0270.97
1_L61_S1.0210.97
15_R85_E1.0170.97
17_L22_G0.9850.96
19_L44_V0.9800.96
25_F53_E0.9750.96
79_R106_E0.9680.96
12_A107_L0.9680.96
61_S65_R0.9680.96
12_A31_R0.9610.96
27_C45_A0.9450.95
68_L98_C0.9430.95
68_L118_L0.9390.95
12_A16_R0.9350.95
60_L82_E0.9280.95
122_E125_P0.9260.95
28_S54_W0.9260.95
25_F90_P0.9120.95
98_C107_L0.9050.94
31_R51_E0.8990.94
59_S115_T0.8980.94
79_R95_V0.8790.93
94_V98_C0.8760.93
4_V9_V0.8710.93
46_R49_G0.8630.93
96_V107_L0.8580.93
7_L60_L0.8520.92
35_R38_R0.8520.92
40_W108_A0.8430.92
23_G116_G0.8410.92
11_L109_M0.8210.91
24_T27_C0.8170.91
74_E78_R0.8110.90
51_E73_L0.8050.90
87_L91_P0.8000.90
49_G93_A0.7970.89
31_R61_S0.7960.89
17_L21_G0.7950.89
73_L96_V0.7900.89
11_L14_R0.7830.89
7_L10_A0.7750.88
95_V108_A0.7730.88
7_L12_A0.7680.88
20_R47_Y0.7680.88
80_P94_V0.7530.87
1_L4_V0.7520.87
9_V13_V0.7500.86
40_W85_E0.7390.86
101_G104_P0.7340.85
31_R65_R0.7300.85
25_F45_A0.7280.85
74_E104_P0.7270.85
72_G84_A0.7250.85
27_C109_M0.7240.84
77_G84_A0.7130.84
29_L54_W0.7120.83
15_R58_F0.7060.83
37_G41_R0.7040.83
100_T111_E0.7030.83
97_E106_E0.6960.82
61_S82_E0.6950.82
31_R48_S0.6920.82
45_A54_W0.6900.82
123_A126_P0.6870.81
6_L9_V0.6840.81
27_C90_P0.6800.81
29_L68_L0.6780.80
42_L89_L0.6750.80
6_L71_R0.6660.79
30_R40_W0.6630.79
28_S90_P0.6600.79
44_V54_W0.6530.78
15_R79_R0.6530.78
81_P85_E0.6500.78
56_R65_R0.6450.77
105_V117_F0.6390.76
78_R111_E0.6380.76
6_L10_A0.6370.76
25_F41_R0.6350.76
19_L26_E0.6310.75
57_L71_R0.6280.75
29_L105_V0.6220.74
82_E86_A0.6210.74
14_R54_W0.6160.74
77_G103_G0.6140.73
4_V8_L0.6010.72
5_L67_V0.5980.71
12_A57_L0.5970.71
23_G109_M0.5950.71
32_R41_R0.5910.71
4_V67_V0.5880.70
50_D112_S0.5850.70
29_L36_G0.5810.69
1_L62_P0.5810.69
109_M115_T0.5800.69
120_W123_A0.5760.69
32_R35_R0.5710.68
36_G84_A0.5710.68
35_R72_G0.5630.67
114_L119_S0.5610.67
40_W79_R0.5590.66
65_R124_A0.5540.66
120_W125_P0.5530.66
53_E63_R0.5530.66
93_A110_S0.5520.65
22_G114_L0.5500.65
24_T55_Y0.5470.65
80_P99_R0.5470.65
12_A29_L0.5470.65
55_Y95_V0.5450.64
42_L45_A0.5410.64
108_A123_A0.5400.64
33_P69_S0.5390.64
26_E50_D0.5350.63
27_C54_W0.5350.63
72_G103_G0.5330.63
19_L23_G0.5330.63
6_L17_L0.5300.62
22_G118_L0.5290.62
37_G69_S0.5270.62
34_A47_Y0.5260.62
22_G52_L0.5250.62
26_E89_L0.5250.62
1_L71_R0.5240.61
14_R22_G0.5240.61
40_W43_G0.5230.61
79_R108_A0.5170.60
98_C121_L0.5170.60
119_S122_E0.5170.60
66_R69_S0.5160.60
70_R120_W0.5150.60
34_A123_A0.5130.60
15_R24_T0.5060.59
56_R109_M0.5050.59
15_R106_E0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.1811 14.3 0.92 Contact Map
2ks1B 1 0.1732 12.5 0.922 Contact Map
2jwaA 2 0.1654 8.7 0.928 Contact Map
1iijA 1 0.126 8 0.928 Contact Map
1ulrA 1 0.4646 7.2 0.93 Contact Map
2fhmA 1 0.4724 7.1 0.93 Contact Map
4hi1A 3 0.5118 6.5 0.932 Contact Map
2kdoA 1 0.3701 6.1 0.932 Contact Map
1w2iA 2 0.4803 5.7 0.933 Contact Map
2m20A 2 0.315 4.6 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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